Amanitins: The Most Poisonous Molecules of the Fungal World [PDF]
Molecules, 2023 Among the toxic metabolites of the fungal world, those that, due to their strong biological effect, can seriously (even fatally) damage the life processes of humans (and certain groups of animals) stand out.
János Vetter
exaly +4 more sources
Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics [PDF]
Toxins, 2021 The consumption of mushrooms has become increasingly popular, partly due to their nutritional and medicinal properties. This has increased the risk of confusion during picking, and thus of intoxication.
Brendan Le Dare +2 more
exaly +4 more sources
Amanitins in Wild Mushrooms: The Development of HPLC-UV-EC and HPLC-DAD-MS Methods for Food Safety Purposes [PDF]
Foods, 2022 Mushroom poisoning remains a serious food safety and health concern in some parts of the world due to its morbidity and mortality. Identification of mushroom toxins at an early stage of suspected intoxication is crucial for a rapid therapeutic decision ...
Isabel Barbosa +3 more
doaj +2 more sources
Rapid, Sensitive, and Accurate Point-of-Care Detection of Lethal Amatoxins in Urine [PDF]
Toxins, 2020 Globally, mushroom poisonings cause about 100 human deaths each year, with thousands of people requiring medical assistance. Dogs are also susceptible to mushroom poisonings and require medical assistance.
Candace S. Bever +7 more
doaj +2 more sources
The MSDIN family in amanitin-producing mushrooms and evolution of the prolyl oligopeptidase genes [PDF]
IMA Fungus, 2018 The biosynthetic pathway for amanitins and related cyclic peptides in deadly Amanita (Amanitaceae) mushrooms represents the first known ribosomal cyclic peptide pathway in the Fungi.
Hong Luo +6 more
doaj +2 more sources
Acute Liver Failure Caused by Amanita phalloides Poisoning [PDF]
International Journal of Hepatology, 2012 Mushroom poisoning is a relatively rare cause of acute liver failure (ALF). The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which ...
Luca Santi +5 more
doaj +2 more sources
Highly sensitive determination of three kinds of amanitins in urine and plasma by ultra performance liquid chromatography-triple quadrupole mass spectrometry coupled with immunoaffinity column clean-up [PDF]
Chinese Journal of Chromatography (Se Pu), 2022 Xiuyao Zhang, Xinxin Cai, Ruifen Li
exaly +2 more sources
Application of single-pass albumin dialysis in the acute phase of amanitin syndrome caused by mushroom poisoning [PDF]
Vojnosanitetski PregledIntroduction. The frequency of mushroom poisoning is increasing both in the world and in our country. The most poisonous type of mushroom in our region is Amanita phalloides, which causes amanitin syndrome in poisoned patients, and it is considered ...
Jovanović Dragana +4 more
doaj +1 more source
Clinical Toxicology, 2022 BACKGROUND AND AIMS: Amanita phalloides poisoning causes severe liver damage which may be potentially fatal. Several treatments are available, but their effectiveness has not been systematically evaluated. We performed a systematic review to investigate the effect of the most commonly used therapies: N-acetylcysteine (NAC), benzylpenicillin (PEN), and ...
Tan, Jia Lin +5 more
openaire +1 more source
Antiproliferative Effect of pHLIP-Amanitin
Biochemistry, 2013 Toxins could be effective anticancer drugs, if their selective delivery into cancer cells could be achieved. We have shown that the energy of membrane-associated folding of water-soluble membrane peptides of the pHLIP (pH low insertion peptide) family could be used to move cell-impermeable cargo across the lipid bilayer into the cytoplasm of cancer ...
Moshnikova, Anna +3 more
openaire +4 more sources