Amanitins: The Most Poisonous Molecules of the Fungal World [PDF]
Molecules, 2023 Among the toxic metabolites of the fungal world, those that, due to their strong biological effect, can seriously (even fatally) damage the life processes of humans (and certain groups of animals) stand out.
János Vetter
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Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics [PDF]
Toxins, 2021 The consumption of mushrooms has become increasingly popular, partly due to their nutritional and medicinal properties. This has increased the risk of confusion during picking, and thus of intoxication.
Brendan Le Daré +2 more
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Amanitins in Wild Mushrooms: The Development of HPLC-UV-EC and HPLC-DAD-MS Methods for Food Safety Purposes [PDF]
Foods, 2022 Mushroom poisoning remains a serious food safety and health concern in some parts of the world due to its morbidity and mortality. Identification of mushroom toxins at an early stage of suspected intoxication is crucial for a rapid therapeutic decision ...
Isabel Barbosa +3 more
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Rapid, Sensitive, and Accurate Point-of-Care Detection of Lethal Amatoxins in Urine [PDF]
Toxins, 2020 Globally, mushroom poisonings cause about 100 human deaths each year, with thousands of people requiring medical assistance. Dogs are also susceptible to mushroom poisonings and require medical assistance.
Candace S. Bever +7 more
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The MSDIN family in amanitin-producing mushrooms and evolution of the prolyl oligopeptidase genes [PDF]
IMA Fungus, 2018 The biosynthetic pathway for amanitins and related cyclic peptides in deadly Amanita (Amanitaceae) mushrooms represents the first known ribosomal cyclic peptide pathway in the Fungi.
Hong Luo +6 more
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Isolable Cysteine Sulfenyl Iodide: Stabilization by a Molecular Cradle, Crystal Structure, and Biologically Relevant Reactivity. [PDF]
ChembiochemAn isolable cysteine sulfenyl iodide (Cys–SI) stabilized by a molecular cradle is reported. X‐ray analysis and reactivity studies reveal hydrolysis to sulfenic acid, electrophilic substitution with indoles, and high reactivity toward amines and dimedone, providing direct evidence for long‐standing proposals on iodine‐mediated protein modification ...
Otaka S +4 more
europepmc +2 more sources
Unraveling the Carcinogenic Mechanisms of Food Contaminants: An Integrated in Silico Framework Combining Network Toxicology, Machine Learning, and Molecular Docking. [PDF]
J Food SciABSTRACT Food contamination poses a significant global health threat with carcinogenic potential, though the molecular pathways connecting contaminants to cancer remain poorly understood. This study sought to identify key molecular targets mediating the carcinogenic effects of nine prevalent dietary contaminants: glyphosate, perfluorooctane sulfonate ...
Chen B +7 more
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Acute Liver Failure Caused by Amanita phalloides Poisoning [PDF]
International Journal of Hepatology, 2012 Mushroom poisoning is a relatively rare cause of acute liver failure (ALF). The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which ...
Luca Santi +5 more
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Highly sensitive determination of three kinds of amanitins in urine and plasma by ultra performance liquid chromatography-triple quadrupole mass spectrometry coupled with immunoaffinity column clean-up [PDF]
Chinese Journal of Chromatography (Se Pu), 2022 Ruifen Li, Xinxin Cai, Xiuyao Zhang
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Application of single-pass albumin dialysis in the acute phase of amanitin syndrome caused by mushroom poisoning [PDF]
Vojnosanitetski PregledIntroduction. The frequency of mushroom poisoning is increasing both in the world and in our country. The most poisonous type of mushroom in our region is Amanita phalloides, which causes amanitin syndrome in poisoned patients, and it is considered ...
Jovanović Dragana +4 more
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