Hypoadrenocorticism in a Dog Following Recovery from Alpha-Amanitin Intoxication [PDF]
Veterinary Sciences, 2023 A 10-year-old, female spayed Labrador Retriever was referred for acute hepatopathy and urinary retention. Blood work from the initial presentation (day 0) revealed a severe, mixed hepatopathy. Over the course of the patient’s hospitalization, the patient
Emily A. Cohen +2 more
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Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro [PDF]
Toxins, 2021 Alpha-amanitin (α-AMA) is a cyclic peptide and one of the most lethal mushroom amatoxins found in Amanita phalloides. α-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA translocation. To investigate the
Doeun Kim +5 more
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Transcriptional inhibition of feline immunodeficiency virus by alpha-amanitin [PDF]
Journal of Veterinary Medical Science, 2021 Alpha-amanitin, one of the amatoxins in egg amanita, has a cyclic peptide structure, and was reported as having antiviral activity against several viruses. We investigated whether α-amanitin has antiviral activity against feline immunodeficiency virus (FIV). FL-4 cells persistently infected with FIV Petaluma were cultured with α-amanitin.
Takashige Kashimoto +2 more
exaly +5 more sources
Long-Term Resistance of Drosophila melanogaster to the Mushroom Toxin Alpha-Amanitin. [PDF]
PLoS ONE, 2015 Insect resistance to toxins exerts not only a great impact on our economy, but also on the ecology of many species. Resistance to one toxin is often associated with cross-resistance to other, sometimes unrelated, chemicals. In this study, we investigated
Chelsea L Mitchell +5 more
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Alpha-Amanitin Poisoning, Nephrotoxicity and Oxidative Stress: An Experimental Mouse Model [PDF]
Iranian Red Crescent Medical Journal, 2015 Alpha-amanitin (α-AMA) plays a major role in Amanita phalloides poisoning, showing toxic effects on multi-organs, particularly on the liver and kidneys. Studies have shown a relationship between α-AMA-related injuries and reactive oxygen species.We aimed to investigate whether there is renal injury and its relationship with oxidative stress after ...
DÜNDAR, ZERRİN DEFNE +5 more
openaire +4 more sources
Deadly Poisonous Turkish Mushrooms Containing Alpha Amanitin [PDF]
Düzce Tıp Fakültesi Dergisi, 2015 Mushroom poisoning is still a serious health problem for Turkey. The mushroom species which cause fatal mushroom poisoning have been reported to contain at least 98% alpha-amanitin.
Ilgaz Akata +3 more
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Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells [PDF]
International Journal of Molecular Sciences, 2022 Sangkyu Lee, Doeun Kim, Hye Suk Lee
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Effects of erdosteine on alpha amanitin-induced hepatotoxicity in mice
Toxin Reviews, 2016 AbstractThe aim of this study was to investigate beneficial effects of erdosteine in the alpha amanitine-induced hepatotoxicity in mice. Three hours after giving alpha amanitin (0.5 mg/kg, i.p.) to the mice, they were administered silibinin (50 mg/kg/d, i.p.) or erdosteine (100 mg/kg/d, oral) therapies once a day for 3 d.
Hayati Kandis, Murat Oktay, Saritas A
exaly +3 more sources
Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning: a case series
Toxicology Communications, 2022 Ingestion of amatoxin-containing mushrooms can lead to fulminant hepatotoxicity and death. Despite recent interest in therapeutic options for amatoxin-exposed patients, there is no single, recommended treatment for amatoxin poisoning. Alpha-amanitin, the
Constance A. Mackenzie +3 more
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Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]
PLoS Genetics, 2007 Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman +3 more
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