Hypoadrenocorticism in a Dog Following Recovery from Alpha-Amanitin Intoxication [PDF]
Veterinary Sciences, 2023 A 10-year-old, female spayed Labrador Retriever was referred for acute hepatopathy and urinary retention. Blood work from the initial presentation (day 0) revealed a severe, mixed hepatopathy. Over the course of the patient’s hospitalization, the patient
Emily A. Cohen +2 more
doaj +9 more sources
Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro [PDF]
Toxins, 2021 Alpha-amanitin (α-AMA) is a cyclic peptide and one of the most lethal mushroom amatoxins found in Amanita phalloides. α-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA translocation. To investigate the
Doeun Kim +5 more
doaj +4 more sources
Transcriptional inhibition of feline immunodeficiency virus by alpha-amanitin [PDF]
Journal of Veterinary Medical Science, 2021 Alpha-amanitin, one of the amatoxins in egg amanita, has a cyclic peptide structure, and was reported as having antiviral activity against several viruses. We investigated whether α-amanitin has antiviral activity against feline immunodeficiency virus (FIV). FL-4 cells persistently infected with FIV Petaluma were cultured with α-amanitin.
Takashige Kashimoto, Taishi Tanabe
exaly +5 more sources
Long-Term Resistance of Drosophila melanogaster to the Mushroom Toxin Alpha-Amanitin. [PDF]
PLoS ONE, 2015 Insect resistance to toxins exerts not only a great impact on our economy, but also on the ecology of many species. Resistance to one toxin is often associated with cross-resistance to other, sometimes unrelated, chemicals. In this study, we investigated
Chelsea L Mitchell +5 more
doaj +6 more sources
Effects of erdosteine on alpha amanitin-induced hepatotoxicity in mice [PDF]
Toxin Reviews, 2016 AbstractThe aim of this study was to investigate beneficial effects of erdosteine in the alpha amanitine-induced hepatotoxicity in mice. Three hours after giving alpha amanitin (0.5 mg/kg, i.p.) to the mice, they were administered silibinin (50 mg/kg/d, i.p.) or erdosteine (100 mg/kg/d, oral) therapies once a day for 3 d.
Kürşat Oğuz Yaykaslı +2 more
exaly +4 more sources
Deadly Poisonous Turkish Mushrooms Containing Alpha Amanitin [PDF]
Düzce Tıp Fakültesi Dergisi, 2015 Mushroom poisoning is still a serious health problem for Turkey. The mushroom species which cause fatal mushroom poisoning have been reported to contain at least 98% alpha-amanitin.
Ilgaz Akata +3 more
doaj +4 more sources
Erdosteine reduces cytotoxicity induced by alpha- and beta-amanitin, but not gamma-amanitin, in CA3 hepatocyte cultures [PDF]
Toxicon, 2022 Amanitin poisoning still has no particular, effective antidote. Erdosteine has been shown to protect numerous tissues, particularly those in the liver.
Kürşat Oğuz Yaykaslı +2 more
exaly +2 more sources
Dermal absorption and toxicity of alpha amanitin in mice [PDF]
Cutaneous and Ocular Toxicology, 2013 The fungus Amanita phalloides is known to contain two main groups of toxins: amanitins and phallotoxins. The amanitins group effectively blocks the RNA polymerase II enzyme found in eukaryotic cells. As alpha amanitin has a lethal effect on the majority of eukaryotic cells, it can be valuable as an antiparasitic or antifungal drug.
Ertugrul, Kaya +7 more
openaire +3 more sources
alpha-Amanitin induced apoptosis in primary cultured dog hepatocytes. [PDF]
Folia Histochemica et Cytobiologica, 2010 Amatoxin poisoning is caused by mushroom species belonging to the genera Amanita, Galerina and Lepiota with the majority of lethal mushroom exposures attributable to Amanita phalloides.
Adam Szelag +8 more
doaj +2 more sources
What is the restoring role of chrysin in alpha amanitin toxicity? [PDF]
, 2015 Aim: To explore whether chrysin has any protective effect against the deadly effect of alpha amanitin on hepatocytes that is one of the major toxins in the structure of Amanita phalloides, which is considered the most important mushroom responsible for fatal mushroom poisonings.
Bakırcı, Sinan +4 more
core +8 more sources