Hypoadrenocorticism in a Dog Following Recovery from Alpha-Amanitin Intoxication [PDF]
Veterinary Sciences, 2023 A 10-year-old, female spayed Labrador Retriever was referred for acute hepatopathy and urinary retention. Blood work from the initial presentation (day 0) revealed a severe, mixed hepatopathy. Over the course of the patient’s hospitalization, the patient
Emily A. Cohen +2 more
doaj +4 more sources
Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro [PDF]
Toxins, 2021 Alpha-amanitin (α-AMA) is a cyclic peptide and one of the most lethal mushroom amatoxins found in Amanita phalloides. α-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA translocation. To investigate the
Doeun Kim +5 more
doaj +4 more sources
Long-Term Resistance of Drosophila melanogaster to the Mushroom Toxin Alpha-Amanitin. [PDF]
PLoS ONE, 2015 Insect resistance to toxins exerts not only a great impact on our economy, but also on the ecology of many species. Resistance to one toxin is often associated with cross-resistance to other, sometimes unrelated, chemicals. In this study, we investigated
Chelsea L Mitchell +5 more
doaj +2 more sources
Protective Effect and Mechanism of Rosiglitazone in α-amanitin-induced Hepatotoxicity Via Activation of PPAR-γ/Nrf2 Signaling Pathway. [PDF]
J Biochem Mol ToxicolABSTRACT α‐amanitin (α‐AMA), the primary lethal toxin of amanita, primarily targets the liver with a high toxicity and a low lethal dose. As the precise mechanism of intoxication is unclear, and specific antidotes are lacking, α‐AMA‐induced liver injury has a high mortality rate.
Lai F +8 more
europepmc +2 more sources
MiR-1 Is Regulated by Hydrogen Peroxide via MAPK and Limits Cell Migration and Invasion. [PDF]
Environ ToxicolABSTRACT MicroRNA‐1 (miR‐1) is a conserved microRNA that is highly expressed in skeletal and cardiac muscle tissues. Moreover, miR‐1 regulates genes and has critical roles in cell migration and invasion. Downregulation of miR‐1 has been found in many pathologies of numerous organs, including the lungs.
Pacurari M, Cox I, Farah I.
europepmc +2 more sources
GLS1-RNA Polymerase II Axis Mediates Glutamine-Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High-Protein Diets. [PDF]
Adv Sci (Weinh)GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wu W +17 more
europepmc +2 more sources
Transcriptional inhibition of feline immunodeficiency virus by alpha-amanitin [PDF]
Journal of Veterinary Medical Science, 2021 Taishi Tanabe +2 more
exaly +2 more sources
Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells [PDF]
International Journal of Molecular Sciences, 2022 Doeun Kim, Min Seo Lee, Sangkyu Lee
exaly +2 more sources
Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning: a case series
Toxicology Communications, 2022 Ingestion of amatoxin-containing mushrooms can lead to fulminant hepatotoxicity and death. Despite recent interest in therapeutic options for amatoxin-exposed patients, there is no single, recommended treatment for amatoxin poisoning. Alpha-amanitin, the
Constance A. Mackenzie +3 more
doaj +1 more source
Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]
PLoS Genetics, 2007 Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman +3 more
doaj +1 more source