Results 21 to 30 of about 5,920 (134)

GLS1-RNA Polymerase II Axis Mediates Glutamine-Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High-Protein Diets. [PDF]

Adv Sci (Weinh)
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wu W, Jiang H, Liu Y, Peng C, Wang H, Yang W, Lyu Z, Sun Y, Ma H, Gu H, Kan W, Jing L, Dong T, Xia C, Lei S, Wu R, Li J, Li J.   +17 more
europepmc   +2 more sources

Alpha-Amanitin Tolerance in Mycophagous Drosophila.

, 1983
Uploaded by Plazi for TaxoDros. We do not have abstracts.
Jaenike, J., Grimaldi, D.A., Sluder, A.E., Greenleaf, A.L.   +3 more
openaire   +1 more source

A Comparison of the Effectiveness of Silibinin and Resveratrol in Preventing Alpha‐Amanitin‐Induced Hepatotoxicity [PDF]

Basic & Clinical Pharmacology & Toxicology, 2018
AbstractAmanita phalloides species mushrooms containing alpha‐amanitin (α‐AMA) are responsible for the majority of fatal mushroom intoxications and can lead to severe poisonings resulting in hepatotoxicity and acute hepatic failure. Existing antidotes, such as silibinin, are not sufficiently effective in the prevention and/or resolution of α‐AMA ...
Şahin, Aynur, Durmuş Sütpideler, Nergiz, Tunçok, Yeşim, Kalkan, Şule, Arıcı, Mualla Aylin, Aksu, İlkay, Atabey, Neşe, Yilmaz, Yeliz, Ergur, Bekir Ugur   +8 more
openaire   +3 more sources

RNA is an integral component of chromatin that contributes to its structural organization.

PLoS ONE, 2007
Chromatin structure is influenced by multiples factors, such as pH, temperature, nature and concentration of counterions, post-translational modifications of histones and binding of structural non-histone proteins.
Antonio Rodríguez-Campos, Fernando Azorín   +1 more
doaj   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Mycotoxins in Basidiomycete Mycelium and Fruiting Bodies: Implications for Eu Novel Food Assessment and Selected International Regulatory Frameworks

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Advances in technology have enabled the efficient and sustainable production of basidiomycete vegetative mycelium, particularly from Pleurotus species, as a novel food source. However, mycelium has yet to receive regulatory approval in many global markets, requiring a better understanding of factors affecting its safety.
Niklas Erik Wilhelm Berglund, Pauliina Vappu Lankinen, Kirsi Susanna Mikkonen   +2 more
wiley   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Detection of alpha-amanitin encoding gene utilizing real-time PCR technique

Tạp chí Kiểm nghiệm và An toàn thực phẩm
Given the limited taxonomy of toxic fungi as well as the large number of mushroom species, identification of mycotoxins in mushroom samples can accelerate information gathering and progress, while increasing Enhanced testing accuracy of testing.
Le Vinh Hoa, Pham Van Quan, Le Thanh Long, Pham Thi Loan, Nguyen Thi Thanh Huyen   +4 more
doaj   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Predator–Microbe Dynamics Inform Strategies for Robust Synthetic Community Assembly

Environmental Microbiology, Volume 28, Issue 6, June 2026.
This Review introduces ecological principles of predator–prey interactions as a new dimension in SynCom design. By linking microbial defence traits, encounter dynamics, and adaptive buffering, it outlines a framework for constructing predator‐resistant synthetic communities with enhanced resilience, stability, and functional performance under natural ...
Eleonora Egidi, Uffe N. Nielsen
wiley   +1 more source