Protective Effect and Mechanism of Rosiglitazone in α-amanitin-induced Hepatotoxicity Via Activation of PPAR-γ/Nrf2 Signaling Pathway. [PDF]
J Biochem Mol ToxicolABSTRACT α‐amanitin (α‐AMA), the primary lethal toxin of amanita, primarily targets the liver with a high toxicity and a low lethal dose. As the precise mechanism of intoxication is unclear, and specific antidotes are lacking, α‐AMA‐induced liver injury has a high mortality rate.
Lai F +8 more
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Non-Coding RNA, 2021 Ribosomal intergenic spacer (rIGS), located between the 45S rRNA coding arrays in humans, is a deep, unexplored source of small and long non-coding RNA molecules transcribed in certain conditions to help a cell generate a stress response, pass through a ...
Anastasia A. Sadova +2 more
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Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation. [PDF]
PLoS Pathogens, 2009 Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) is a negative-stranded RNA virus with a tripartite genome. RVFV is transmitted by mosquitoes and causes fever and severe hemorrhagic illness among humans, and fever and high rates of
Tetsuro Ikegami +5 more
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Toxins, 2018 One of the deadliest mushrooms is the death cap mushroom, Amanita phalloides. The most toxic constituent is α-amanitin, a bicyclic octapeptide, which damages the liver and kidneys.
Candace S. Bever +4 more
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Alpha-1 antichymotrypsin is involved in astrocyte injury in concert with arginine-vasopressin during the development of acute hepatic encephalopathy. [PDF]
PLoS ONE, 2017 We developed a bio-artificial liver (BAL) using a radial-flow bioreactor and rescued mini-pig models with lethal acute liver failure (ALF). The point of the rescue is the recovery from hepatic encephalopathy (HE).
Jonghyuk Park +11 more
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RNA Pol II promotes transcription of centromeric satellite DNA in beetles. [PDF]
PLoS ONE, 2008 Transcripts of centromeric satellite DNAs are known to play a role in heterochromatin formation as well as in establishment of the kinetochore.
Zeljka Pezer, Durdica Ugarković
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alpha-Amanitin induced apoptosis in primary cultured dog hepatocytes.
Folia Histochemica et Cytobiologica, 2010 Amatoxin poisoning is caused by mushroom species belonging to the genera Amanita, Galerina and Lepiota with the majority of lethal mushroom exposures attributable to Amanita phalloides.
Adam Szelag +8 more
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Single cell analysis of transcriptional activation dynamics.
PLoS ONE, 2010 BackgroundGene activation is thought to occur through a series of temporally defined regulatory steps. However, this process has not been completely evaluated in single living mammalian cells.Methodology/principal findingsTo investigate the timing and ...
Ilona U Rafalska-Metcalf +4 more
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Effect of gut microbiota on α‐amanitin tolerance in Drosophila tripunctata
Ecology and Evolution, 2020 The bacterial gut microbiota of many animals is known to be important for many physiological functions including detoxification. The selective pressures imposed on insects by exposure to toxins may also be selective pressures on their symbiotic bacteria,
Logan H. Griffin, Laura K. Reed
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MiR-1 Is Regulated by Hydrogen Peroxide via MAPK and Limits Cell Migration and Invasion. [PDF]
Environ ToxicolABSTRACT MicroRNA‐1 (miR‐1) is a conserved microRNA that is highly expressed in skeletal and cardiac muscle tissues. Moreover, miR‐1 regulates genes and has critical roles in cell migration and invasion. Downregulation of miR‐1 has been found in many pathologies of numerous organs, including the lungs.
Pacurari M, Cox I, Farah I.
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