Evaluation and comparison of alpha- and beta-amanitin toxicity on MCF-7 cell line [PDF]
Turkish Journal of Medical Sciences, 2014 Background/aim: Alpha- and beta-amanitins are the main toxins of the poisonous Amanita phalloides mushroom. Although there are many studies available concerning alpha-amanitin, there are limited data about beta-amanitin in the literature. Therefore, this
Emine Yaykasli +2 more
exaly +4 more sources
Alpha-Amanitin Poisoning, Nephrotoxicity and Oxidative Stress: An Experimental Mouse Model. [PDF]
Iran Red Crescent Med J, 2015 Alpha-amanitin (α-AMA) plays a major role in Amanita phalloides poisoning, showing toxic effects on multi-organs, particularly on the liver and kidneys. Studies have shown a relationship between α-AMA-related injuries and reactive oxygen species.We aimed to investigate whether there is renal injury and its relationship with oxidative stress after ...
Ergin M +5 more
europepmc +5 more sources
Effect of gut microbiota on α‐amanitin tolerance in Drosophila tripunctata
Ecology and Evolution, 2020 The bacterial gut microbiota of many animals is known to be important for many physiological functions including detoxification. The selective pressures imposed on insects by exposure to toxins may also be selective pressures on their symbiotic bacteria,
Logan H. Griffin, Laura K. Reed
doaj +2 more sources
Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells [PDF]
International Journal of Molecular Sciences, 2022 Sangkyu Lee, Doeun Kim, Hye Suk Lee
exaly +2 more sources
Mycotoxins in Basidiomycete Mycelium and Fruiting Bodies: Implications for Eu Novel Food Assessment and Selected International Regulatory Frameworks. [PDF]
Compr Rev Food Sci Food SafABSTRACT Advances in technology have enabled the efficient and sustainable production of basidiomycete vegetative mycelium, particularly from Pleurotus species, as a novel food source. However, mycelium has yet to receive regulatory approval in many global markets, requiring a better understanding of factors affecting its safety.
Berglund NEW, Lankinen PV, Mikkonen KS.
europepmc +2 more sources
Effects of thymoquinone on alpha-amanitin induced hepatotoxicity in human C3A hepatocytes [PDF]
, 2022 Thymoquinone (TQ) has shown hepatoprotective effects in various experimental studies. We aimed to investigate the possible beneficial effects of TQ regarding its prevention of alpha-amanitin induced hepatotoxicity in human C3A hepatocytes.
Kaya, Ertuğrul +8 more
core +2 more sources
Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning: a case series
Toxicology Communications, 2022 Ingestion of amatoxin-containing mushrooms can lead to fulminant hepatotoxicity and death. Despite recent interest in therapeutic options for amatoxin-exposed patients, there is no single, recommended treatment for amatoxin poisoning. Alpha-amanitin, the
Constance A. Mackenzie +3 more
doaj +1 more source
Protective Effect and Mechanism of Rosiglitazone in α-amanitin-induced Hepatotoxicity Via Activation of PPAR-γ/Nrf2 Signaling Pathway. [PDF]
J Biochem Mol ToxicolABSTRACT α‐amanitin (α‐AMA), the primary lethal toxin of amanita, primarily targets the liver with a high toxicity and a low lethal dose. As the precise mechanism of intoxication is unclear, and specific antidotes are lacking, α‐AMA‐induced liver injury has a high mortality rate.
Lai F +8 more
europepmc +2 more sources
Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]
PLoS Genetics, 2007 Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman +3 more
doaj +1 more source
Non-Coding RNA, 2021 Ribosomal intergenic spacer (rIGS), located between the 45S rRNA coding arrays in humans, is a deep, unexplored source of small and long non-coding RNA molecules transcribed in certain conditions to help a cell generate a stress response, pass through a ...
Anastasia A. Sadova +2 more
doaj +1 more source