Results 41 to 50 of about 839,892 (155)

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Purification and in vitro toxicity of gamma amanitin [PDF]

, 2015
Yaykasli, Kursat/0000-0001-7550-6370; Kaya, Ertugrul/0000-0003-0081-682XWOS: 000375245500008We aimed to obtain gamma amanitin with high purity through a purification process and compare toxic effects of alpha, beta, and gamma amanitin.
Kaya, Ertuğrul, Bayram, Recep, Yaykaşlı, Kürşat Oğuz, Bakırcı, Sinan, Yılmaz, İsmail, Bayram, Sait   +5 more
core   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Predator–Microbe Dynamics Inform Strategies for Robust Synthetic Community Assembly

Environmental Microbiology, Volume 28, Issue 6, June 2026.
This Review introduces ecological principles of predator–prey interactions as a new dimension in SynCom design. By linking microbial defence traits, encounter dynamics, and adaptive buffering, it outlines a framework for constructing predator‐resistant synthetic communities with enhanced resilience, stability, and functional performance under natural ...
Eleonora Egidi, Uffe N. Nielsen
wiley   +1 more source

Convergence and parallelism in the evolution of plant metabolism

Journal of Integrative Plant Biology, Volume 68, Issue 4, Page 1013-1031, April 2026.
Similar traits in different organisms may originate from shared ancestry or evolve independently. The terminology used to define phenotypic similarity is often confusing. This review attempts to clarify the definitions and present examples from plant domestication and specialized metabolism to explain how complex traits evolve repeatedly in plants ...
Federico Scossa, Mustafa Bulut, Thomas Naake, John C. D'Auria, Alisdair R. Fernie   +4 more
wiley   +1 more source

Isolation and characterization of an alpha-amanitin-resistant rat myoblast mutant cell line possessing alpha-amanitin-resistant RNA polymerase II.

Journal of Biological Chemistry, 1975
Cultures of the rat skeletal muscle myoblast cell line, L6, were treated with the mutagen ethylmethanesulfonate and grown in the presence of alpha-amanitin, an inhibitor of RNA polymerase II in vitro. One clonal cell line, Ama102, resistant tc the cytotoxic action of 2 mu-g/ml of alpha-amanitin was isolated and extensively characterized.
D G, Somers, M L, Pearson, C J, Ingles
openaire   +2 more sources

Transposable elements: Functional aspects and applications as drivers of crop innovation

Crop Science, Volume 66, Issue 2, March/April 2026.
Abstract Transposable elements (TEs), which were once relegated to the status of genomic parasites, are today accepted as important agents of plant genome evolution and adaptation. This review integrates evidence pointing to their dual function as drivers of genetic diversity and instability, with a focus on their contribution to phenotypic innovation,
Flávia Layse Belém Medeiros, José Ribamar Costa Ferreira‐Neto, Jarbson Henrique Oliveira Silva, Cinthia Carla Claudino Grangeiro Nunes, Ana Luíza Trajano Mangueira de Melo, Ayug Bezerra Lemos, Madson Allan de Luna‐Aragão, Agnes Angélica Guedes de Barros, Simon Orozco‐Arias, Eliseu Binneck, Francismar Correa Marcelino‐Guimarães, Ana Cristina Brasileiro‐Vidal, Ana Maria Benko‐Iseppon   +12 more
wiley   +1 more source

Upstream CB1R Regulation of β‐Adrenergic Memory Consolidation

Hippocampus, Volume 36, Issue 2, March 2026.
ABSTRACT Object recognition memory (ORM) plays a key role in identifying familiar items and encoding episodic information. ORM consolidation depends on β‐adrenergic receptor (βAR) signaling and is associated with increased BDNF expression in the dorsal hippocampus.
Janine I. Rossato, Lucas Ribeiro, Thais Lima‐Silva, Raquel Araujo, Rodrigo Orvate, Anna Lyvia Azevedo, Nina Bevilaqua Cammarota, Ana Luizi Baracho, Livia Carneiro, Martín Cammarota   +9 more
wiley   +1 more source

Structure of the recombinant RNA polymerase from African Swine Fever Virus

Nature Communications
African Swine Fever Virus is a Nucleo-Cytoplasmic Large DNA Virus that causes an incurable haemorrhagic fever in pigs with a high impact on global food security.
Simona Pilotto, Michal Sýkora, Gwenny Cackett, Christopher Dulson, Finn Werner   +4 more
doaj   +1 more source

Demystifying fungal systematics: A gateway to fungal literacy and societal/ecological relevance through familiar species

PLANTS, PEOPLE, PLANET, Volume 8, Issue 2, Page 499-515, March 2026.
Fungal systematics can feel overwhelming given the vast species diversity within this kingdom, with numerous subgroups at every taxonomic rank. This often creates a disconnect between the undertsnidng of fungal taxonomic diversity and their societal relevance.
Anna Vaiana, Francis Martin, Rasmus Kjøller, Toby Spribille, Garima Singh   +4 more
wiley   +1 more source