Development of Simultaneous Analytical Method of Three Polypeptide Toxins α-Amanitin, β-Amanitin and Phalloidin in Poisonous Mushrooms and Human Serum Using UHPLC-MS/MS. [PDF]
J Mass SpectromABSTRACT Accidental ingestion of toxic mushrooms remains a global public health concern because of the presence of highly potent peptide toxins such as α‐amanitin, β‐amanitin, and phalloidin. These compounds exhibit strong hepatotoxicity and can lead to acute liver failure and death.
Ok HJ +5 more
europepmc +2 more sources
Isolable Cysteine Sulfenyl Iodide: Stabilization by a Molecular Cradle, Crystal Structure, and Biologically Relevant Reactivity. [PDF]
ChembiochemAn isolable cysteine sulfenyl iodide (Cys–SI) stabilized by a molecular cradle is reported. X‐ray analysis and reactivity studies reveal hydrolysis to sulfenic acid, electrophilic substitution with indoles, and high reactivity toward amines and dimedone, providing direct evidence for long‐standing proposals on iodine‐mediated protein modification ...
Otaka S +4 more
europepmc +2 more sources
Unraveling the Carcinogenic Mechanisms of Food Contaminants: An Integrated in Silico Framework Combining Network Toxicology, Machine Learning, and Molecular Docking. [PDF]
J Food SciABSTRACT Food contamination poses a significant global health threat with carcinogenic potential, though the molecular pathways connecting contaminants to cancer remain poorly understood. This study sought to identify key molecular targets mediating the carcinogenic effects of nine prevalent dietary contaminants: glyphosate, perfluorooctane sulfonate ...
Chen B +7 more
europepmc +2 more sources
The occurrence of ansamers in the synthesis of cyclic peptides [PDF]
Nat Commun, 2022 α-Amanitin is a bicyclic octapeptide composed of a macrolactam with a tryptathionine cross-link forming a handle. Previously, the occurrence of isomers of amanitin, termed atropisomers has been postulated.
Irran, Elisabeth +6 more
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The most dreadful mushroom toxins [PDF]
EXCLI JMushroom consumption is a worldwide custom that continues to grow in popularity. On the other hand, foraging for wild mushrooms can lead to serious disease and even death if deadly mushrooms are accidentally consumed.
Irene Gouvinhas +3 more
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Rapid analysis of amatoxins in human urine by means of affinity column chromatography and liquid chromatography-high-resolution tandem mass spectrometry [PDF]
Sci RepAnalysis of amatoxins is of great importance as these cyclic peptides contribute to a high number of fatalities each year. Development of analytical approaches needs to focus on rapid, sensitive, and reliable methods.
Bever, Candace S. +5 more
core +2 more sources
Analysis of α- and β-amanitin in Human Plasma at Subnanogram per Milliliter Levels by Reversed Phase Ultra-High Performance Liquid Chromatography Coupled to Orbitrap Mass Spectrometry [PDF]
Toxins (Basel), 2020 Amatoxins are known to be one of the main causes of serious to fatal mushroom intoxication. Thorough treatment, analytical confirmation, or exclusion of amatoxin intake is crucial in the case of any suspected mushroom poisoning.
Bambauer, Thomas P. +3 more
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Application of single-pass albumin dialysis in the acute phase of amanitin syndrome caused by mushroom poisoning [PDF]
Vojnosanitetski PregledIntroduction. The frequency of mushroom poisoning is increasing both in the world and in our country. The most poisonous type of mushroom in our region is Amanita phalloides, which causes amanitin syndrome in poisoned patients, and it is considered ...
Jovanović Dragana +4 more
doaj +1 more source
Amatoksiinimürgistus. Kirjanduse ülevaade ja valge kärbseseene mürgistusega kahe patsiendi haigusjuht [PDF]
, 2022 Amatoksiine sisaldavad seened (valge ja roheline kärbseseen) võivad juba väikese koguse söömisel olla eluohtlikud ja põhjustada ägedat maksapuudulikkust.
Lillo, Karl Erik
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Quantification of alpha-amanitin in biological samples by HPLC using simultaneous UV- diode array and electrochemical detection [PDF]
, 2015 α-Amanitin is a natural bicyclic octapeptide, from the family of amatoxins, present in the deadly mushroom species Amanita phalloides. The toxicological and clinical interests raised by this toxin, require highly sensitive, accurate and reproducible ...
Baptista, Paula +4 more
core +1 more source