Results 11 to 20 of about 439 (132)
Clinical Toxicology, 2022 BACKGROUND AND AIMS: Amanita phalloides poisoning causes severe liver damage which may be potentially fatal. Several treatments are available, but their effectiveness has not been systematically evaluated. We performed a systematic review to investigate the effect of the most commonly used therapies: N-acetylcysteine (NAC), benzylpenicillin (PEN), and ...
Tan, Jia Lin +5 more
openaire +1 more source
Antiproliferative Effect of pHLIP-Amanitin
Biochemistry, 2013 Toxins could be effective anticancer drugs, if their selective delivery into cancer cells could be achieved. We have shown that the energy of membrane-associated folding of water-soluble membrane peptides of the pHLIP (pH low insertion peptide) family could be used to move cell-impermeable cargo across the lipid bilayer into the cytoplasm of cancer ...
Moshnikova, Anna +3 more
openaire +4 more sources
Toxicon, 2022 Amanitin poisoning still has no particular, effective antidote. Erdosteine has been shown to protect numerous tissues, particularly those in the liver. This study investigates the potential therapeutic effects of erdosteine on alpha-, beta- and gamma-amanitin-induced hepatotoxicity in in vitro models.
Recep Bayram +3 more
openaire +3 more sources
Prenatal Diagnosis, EarlyView.ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde +4 more
wiley +1 more source
British Journal of Haematology, EarlyView.Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi +3 more
wiley +1 more source
Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives
MedComm, Volume 7, Issue 8, August 2026.The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng +9 more
wiley +1 more source
The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos
Advanced Science, Volume 13, Issue 36, 29 June 2026.Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan +8 more
wiley +1 more source
Predator–Microbe Dynamics Inform Strategies for Robust Synthetic Community Assembly
Environmental Microbiology, Volume 28, Issue 6, June 2026.This Review introduces ecological principles of predator–prey interactions as a new dimension in SynCom design. By linking microbial defence traits, encounter dynamics, and adaptive buffering, it outlines a framework for constructing predator‐resistant synthetic communities with enhanced resilience, stability, and functional performance under natural ...
Eleonora Egidi, Uffe N. Nielsen
wiley +1 more source
Convergence and parallelism in the evolution of plant metabolism
Journal of Integrative Plant Biology, Volume 68, Issue 4, Page 1013-1031, April 2026.Similar traits in different organisms may originate from shared ancestry or evolve independently. The terminology used to define phenotypic similarity is often confusing. This review attempts to clarify the definitions and present examples from plant domestication and specialized metabolism to explain how complex traits evolve repeatedly in plants ...
Federico Scossa +4 more
wiley +1 more source
Transposable elements: Functional aspects and applications as drivers of crop innovation
Crop Science, Volume 66, Issue 2, March/April 2026.Abstract Transposable elements (TEs), which were once relegated to the status of genomic parasites, are today accepted as important agents of plant genome evolution and adaptation. This review integrates evidence pointing to their dual function as drivers of genetic diversity and instability, with a focus on their contribution to phenotypic innovation,
Flávia Layse Belém Medeiros +12 more
wiley +1 more source