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Strategic and Chemical Advances in Antibody-Drug Conjugates. [PDF]

open access: yesPharmaceutics
Alradwan IA   +9 more
europepmc   +1 more source
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Production of antibodies to amanitins as the basis for their radioimmunoassay

Experientia, 1975
The production of antibodies against amanitins is described. By means of these antibodies, a radioimmunoassay was developed which allows detection of as little as 0.5 ng of amanitins in 1 ml of serum. By this method, the clearance of alpha-amanitin from the blood of poisoned mice was measured.
C Busi, L Fiume, Fiume L
exaly   +3 more sources

Fifty years of amanitin

Experientia, 1991
Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far.
T, Wieland, H, Faulstich
openaire   +2 more sources

Conformation and toxicity of amanitins

Experientia, 1973
Die Cottoneffekte der Amanitine konnten dem Indolteil bzw. den Amidgruppen des Molekuhls zugeordnet werden. Das untoxische Amanullin besitzt die gleiche Konformation wie die toxischen Peptide, das untoxische Aldoamanitin dagegen eine andere.
Faulstich, H.   +3 more
openaire   +3 more sources

Ultrasensitive paper sensor for simultaneous detection of alpha-amanitin and beta-amanitin by the production of monoclonal antibodies

Food Chemistry, 2022
Amanitin (AMA) is responsible for human fatalities after ingestion of poisonous mushrooms, thus, a rapid and accurate detection method is urgently needed. Here, gold nanoparticle-based immunosensor with monoclonal antibody against AMA was constructed for rapid detection of alpha- and beta-amanitin (α- and β-AMA) in mushroom, serum and urine samples ...
Shengyang, Zhou   +8 more
openaire   +2 more sources

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