Results 81 to 90 of about 439 (132)
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Archives of Virology, 1978
The advances in virus research made possible by the use of amanitins are reported; they include i) determination of the genetic source (i.e. cellular or viral) of the RNA polymerase transcribing the viral genome, and ii) mechanism of virus-induced shut-off of host RNA synthesis.
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The advances in virus research made possible by the use of amanitins are reported; they include i) determination of the genetic source (i.e. cellular or viral) of the RNA polymerase transcribing the viral genome, and ii) mechanism of virus-induced shut-off of host RNA synthesis.
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Mechanism and treatment of α-amanitin poisoning
Archives of Toxicology, 2022Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment mainly focuses on symptomatic and supportive therapy. The pathogenesis of α-amanitin mainly includes: α-amanitin can inhibit the activity of RNA polymeraseII in the ...
Jinfang Xue +4 more
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Abstract 735: SAR of amanitin and optimization of linker-amanitin derivatives for solid tumors
Cancer Research, 2018Abstract Background: ATACs (Antibody Targeted Amanitin Conjugates) comprise a new class of antibody-drug conjugates using amanitin as toxic payload. Amanitin binds to the eukaryotic RNA pol II and thereby inhibits the cellular transcription process at very low concentrations.
Michael Kulke +7 more
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Viroid replication is inhibited by α-amanitin
Nature, 1979VIROIDS are infectious single-stranded circular RNA molecules1 which cause disease in higher Plants. Although the complete molecular structure of one viroid has recently been established2, the mechanism of viroid replication and patho-genesis is still unknown.
H P, Mühlbach, H L, Sänger
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Amanitin binding to RNA polymerase II in α-amanitin-resistant rat myoblast mutants
Journal of Molecular Biology, 1977A series of independent α-amanitin-resistant (Ama R ) mutants have been isolated from diploid and tetraploid strains of L6 rat myoblast cells. With one exception, these mutants contain both α-amanitin-sensitive wild-type and α-amanitin-resistant mutant RNA polymerase II activities.
M M, Crerar +5 more
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Synthesis of a Cytotoxic Amanitin for Biorthogonal Conjugation
ChemBioChem, 2015AbstractAlpha‐amanitin is an exceedingly toxic, naturally occurring, bicyclic octapeptide that inhibits RNA polymerase and results in cellular and organismal death. Here we report the straightforward synthesis of an amanitin analogue that exhibited near‐native toxicity.
Zhao L +7 more
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α-Amanitin: Inactivation by bovine lactoperoxidase
Experientia, 1979The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen ...
P W, Morris, K M, Kelley, W G, Logas
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Total Synthesis of α‐ and β‐Amanitin
Angewandte Chemie International Edition, 2020Abstractα‐Amanitin and related amatoxins have been studied for more than six decades mostly by isolation from death cap mushrooms. The total synthesis, however, remained challenging due to unique structural features. α‐Amanitin is a potent inhibitor of RNA polymerase II. Interrupting the basic transcription processes of eukaryotes leads to apoptosis of
Christian Lutz +4 more
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1975
So far, most experimental investigations concerning amanitin poisoning have been done in the mouse or in the rat. In order to obtain conditions which could be better compared to human intoxication, we chose the dog for experiments. Among the amatoxins available, there are two compounds, which can be radioactively labelled: 14[C]O-methyl-γ-amanitin and ...
Faulstich, H., Fauser, U.
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So far, most experimental investigations concerning amanitin poisoning have been done in the mouse or in the rat. In order to obtain conditions which could be better compared to human intoxication, we chose the dog for experiments. Among the amatoxins available, there are two compounds, which can be radioactively labelled: 14[C]O-methyl-γ-amanitin and ...
Faulstich, H., Fauser, U.
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Analytical Biochemistry, 1985
A high-performance liquid chromatographic assay of alpha-amanitin and beta-amanitin in human serum, urine, or stomach washings is described. Sample preparation involves a chemical step with deproteinization and organic solvent treatment, and a selective cleanup and concentration step on reversed-phase prepacked cartridges.
F, Jehl +5 more
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A high-performance liquid chromatographic assay of alpha-amanitin and beta-amanitin in human serum, urine, or stomach washings is described. Sample preparation involves a chemical step with deproteinization and organic solvent treatment, and a selective cleanup and concentration step on reversed-phase prepacked cartridges.
F, Jehl +5 more
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