Production of antibodies to amanitins as the basis for their radioimmunoassay [PDF]
Experientia, 1975 The production of antibodies against amanitins is described. By means of these antibodies, a radioimmunoassay was developed which allows detection of as little as 0.5 ng of amanitins in 1 ml of serum. By this method, the clearance of alpha-amanitin from the blood of poisoned mice was measured.
L Fiume, C Busi, Fiume L
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Conformation and toxicity of amanitins [PDF]
Experientia, 1973 Die Cottoneffekte der Amanitine konnten dem Indolteil bzw. den Amidgruppen des Molekuhls zugeordnet werden. Das untoxische Amanullin besitzt die gleiche Konformation wie die toxischen Peptide, das untoxische Aldoamanitin dagegen eine andere.
Faulstich, H. +3 more
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Amanitins in virus research [PDF]
Archives of Virology, 1978 The advances in virus research made possible by the use of amanitins are reported; they include i) determination of the genetic source (i.e. cellular or viral) of the RNA polymerase transcribing the viral genome, and ii) mechanism of virus-induced shut-off of host RNA synthesis.
Gabriella Campadelli-Fiume
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Rationally Designed Amanitins Achieve Enhanced Cytotoxicity [PDF]
Journal of Medicinal Chemistry, 2022 For 70 years, α-amanitin, the most cytotoxic peptide in its class, has been without a synthetic rival; through synthesis, we address the structure–activity relationships to inform the design of new amatoxins and disclose analogues that are more cytotoxic
Mihajlo Todorović +2 more
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In order to understand the basis upon which amanitin-accumulating species of Amanita are able to develop in the presence of these specific inhibitors of RNA synthesis, the in vitro RNA synthesizing activities of nuclei isolated from amanitin-accumulating species.
James F Preston
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Development, optimization and application of an analytical methodology by ultra performance liquid chromatography–tandem mass spectrometry for determination of amanitins in urine and liver samples [PDF]
Analytica Chimica Acta, 2013 Amanitins, highly toxic cyclopeptides isolated from various Amanita species, are the most potent poisons accounting for the hazardous effects on intestinal epithelium cells and hepatocytes, and probably the sole cause of fatal human poisoning.
Marta Leite +2 more
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Über die Inhaltsstoffe des grünen Knollenblätterpilzes, XL. Oxydation und Reduktion an der γ.δ‐Dihydroxy‐isoleucin‐Seitenkette des O‐Methyl‐α‐amanitins. Methyl‐aldoamanitin, ein ungiftiges Abbauprodukt [PDF]
Justus Liebigs Annalen Der Chemie, 1970 Die γ.δ-Dihydroxy-isoleucin-Seitenkette des O-Methyl-α-amanitins (1b) läβt sich durch kurze Perjodatoxydation zum Aldehyd 2 mit einem C-Atom weniger abbauen; O-Methyl-aldoamanitin (2) ist ungiftig. Durch Reduktion mit NaBH4 wird eine γ-ständige OH-Gruppe
Theodor Wieland
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AMANITINS DO NOT BIND TO SERUM ALBUMIN
Lancet, The, 1977L Fiume, Lucio Montanaro, C Busi
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Effective production of amanitins by two-step cultivation of the basidiomycete, Galerina fasciculata GF-060 [PDF]
Journal of Bioscience and Bioengineering, 2000 Takao Shinozawa
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