Results 111 to 120 of about 486 (156)
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Experientia, 1991
Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far.
T, Wieland, H, Faulstich
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Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far.
T, Wieland, H, Faulstich
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Methods for chromatographic determination of amanitins and related toxins in biological samples [PDF]
Biomedical Applications, 1992 D Michelot +2 more
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Food Chemistry, 2022
Amanitin (AMA) is responsible for human fatalities after ingestion of poisonous mushrooms, thus, a rapid and accurate detection method is urgently needed. Here, gold nanoparticle-based immunosensor with monoclonal antibody against AMA was constructed for rapid detection of alpha- and beta-amanitin (α- and β-AMA) in mushroom, serum and urine samples ...
Shengyang, Zhou +8 more
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Amanitin (AMA) is responsible for human fatalities after ingestion of poisonous mushrooms, thus, a rapid and accurate detection method is urgently needed. Here, gold nanoparticle-based immunosensor with monoclonal antibody against AMA was constructed for rapid detection of alpha- and beta-amanitin (α- and β-AMA) in mushroom, serum and urine samples ...
Shengyang, Zhou +8 more
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Mechanism and treatment of α-amanitin poisoning
Archives of Toxicology, 2022Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment mainly focuses on symptomatic and supportive therapy. The pathogenesis of α-amanitin mainly includes: α-amanitin can inhibit the activity of RNA polymeraseII in the ...
Jinfang Xue +4 more
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Determination of amanitins and phallotoxins in wild mushrooms by online liquid chromatography-diode array detector-tandem mass spectrometry [PDF]
Chinese Journal of Chromatography (Se Pu), 2017 Jingshun Zhang +2 more
exaly +2 more sources
Viroid replication is inhibited by α-amanitin
Nature, 1979VIROIDS are infectious single-stranded circular RNA molecules1 which cause disease in higher Plants. Although the complete molecular structure of one viroid has recently been established2, the mechanism of viroid replication and patho-genesis is still unknown.
H P, Mühlbach, H L, Sänger
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Abstract 735: SAR of amanitin and optimization of linker-amanitin derivatives for solid tumors
Cancer Research, 2018Abstract Background: ATACs (Antibody Targeted Amanitin Conjugates) comprise a new class of antibody-drug conjugates using amanitin as toxic payload. Amanitin binds to the eukaryotic RNA pol II and thereby inhibits the cellular transcription process at very low concentrations.
Michael Kulke +7 more
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Amanitin binding to RNA polymerase II in α-amanitin-resistant rat myoblast mutants
Journal of Molecular Biology, 1977A series of independent α-amanitin-resistant (Ama R ) mutants have been isolated from diploid and tetraploid strains of L6 rat myoblast cells. With one exception, these mutants contain both α-amanitin-sensitive wild-type and α-amanitin-resistant mutant RNA polymerase II activities.
M M, Crerar +5 more
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Synthesis of a Cytotoxic Amanitin for Biorthogonal Conjugation
ChemBioChem, 2015AbstractAlpha‐amanitin is an exceedingly toxic, naturally occurring, bicyclic octapeptide that inhibits RNA polymerase and results in cellular and organismal death. Here we report the straightforward synthesis of an amanitin analogue that exhibited near‐native toxicity.
Zhao L +7 more
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α-Amanitin: Inactivation by bovine lactoperoxidase
Experientia, 1979The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen ...
P W, Morris, K M, Kelley, W G, Logas
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