Results 111 to 120 of about 358 (125)
High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients [PDF]
Cell Communication and Signaling, 2014 Despite recent advances in cancer therapeutics in general, the survival of patients with head and neck squamous cell carcinomas (HNSCCs) has not improved substantially over the past few decades. HNSCC cells often exhibit invasive and metastatic phenotypes, and expression of epidermal growth factor receptor (EGFR) and cortactin has been highly ...
Hiromitsu Hatakeyama +2 more
exaly +6 more sources
IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells [PDF]
Cell Cycle, 2008 Global control of mRNA translation plays key roles in cell regulation, including growth, differentiation and apoptosis. Human monocyte-like U937 cells differentiate into macrophage-like cells upon 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, a process which is known to be accompanied with a large decrease in general protein synthesis. Here, we
Antonis Koromilas, Dionissios Baltzis
exaly +4 more sources
Assays and Properties of the ArfGAPs, AMAP1 and AMAP2, in Arf6 Function
Methods in Enzymology, 2005 The GTPase-activating protein (GAP) domain for Arfs primarily consists of a zinc-finger structure, which is not present in known GAPs for the other Ras-superfamily GTPases. More than 20 genes have been found to encode proteins bearing the ArfGAP domain in the human genome: a number that is much larger than that of the Arf isoforms. Several Arf isoforms,
Yasuhito Onodera +2 more
exaly +4 more sources
Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities [PDF]
EMBO Journal, 2005 Identification of the molecular machinery employed in cancer invasion, but not in normal adult cells, will greatly contribute to cancer therapeutics. Here we found that an ArfGAP, AMAP1/PAG2, is expressed at high levels in highly invasive breast cancer cells, but at very low levels in noninvasive breast cancer cells and normal mammary epithelial cells.
Yasuhito Onodera, Ari Hashimoto
exaly +3 more sources
AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions [PDF]
Scientific Reports, 2014 NF-κB is a major transcriptional factor regulating many cellular functions including inflammation; therefore, its appropriate control is of high importance. The detailed mechanism of its activation has been well characterized, but that of negative regulation is poorly understood.
Hidenori Arai +2 more
exaly +3 more sources
CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery [PDF]
EMBO Journal, 2007 Expression of AMAP1 correlates well with the invasive phenotypes and malignancy of human primary breast carcinomas. AMAP1 recruits its binding proteins, such as cortactin and paxillin, to sites of Arf6 activation to form invadopodia. A mouse ortholog of AMAP1, ASAP1, is known to bind to CIN85, a binding partner of an E3 ligase, Cbl. Here, we found that
Jin-Min Nam, Yasuhito Onodera
exaly +3 more sources
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2006 Invasive potentials of carcinomas greatly contribute to their metastasis, which is a major threat in most cancers. We have recently shown that Arf6 plays a pivotal role in breast cancer invasive activities and identified AMAP1 as an effector of GTP-Arf6 in invasion.
Hideo Wada +2 more
exaly +3 more sources
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Cancer Research, 2016
Abstract Background: Recently, irradiation combined with Cetuximab (Cmab) is being one of the standard therapeutic options against head and neck squamous cell carcinoma (HNSCC), especially in advanced/recurrent cases. While this concurrent chemo-radiotherapy is widely accepted and tolerated, Cmab monotherapy has been reported to be ...
Yoshifumi Matsumoto +3 more
openaire +1 more source
Abstract Background: Recently, irradiation combined with Cetuximab (Cmab) is being one of the standard therapeutic options against head and neck squamous cell carcinoma (HNSCC), especially in advanced/recurrent cases. While this concurrent chemo-radiotherapy is widely accepted and tolerated, Cmab monotherapy has been reported to be ...
Yoshifumi Matsumoto +3 more
openaire +1 more source