Results 41 to 50 of about 62,562 (308)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Fine-grained wireless propagation ambience sensing

open access: yesInternational Journal of Distributed Sensor Networks, 2018
The ubiquitous wireless network infrastructure and the need of people’s indoor sensing inspire the work leveraging wireless signal into broad spectrum for indoor applications, including indoor localization, human–computer interaction, and activity ...
Nan Jing, Yu Sun, Lin Wang, Jinxin Shan
doaj   +1 more source

Un silence sans ambiance. Hammershøi, les impressionnistes et le tournant atmosphérique contemporain

open access: yesAmbiances, 2023
This article aims at problematizing, from an aesthetic perspective, the contemporary “atmospheric turn”. From a confrontation between French impressionist painting and the painting of the Danish Vilhelm Hammershøi (1864-1916), we thus distinguish three ...
Hugues Choplin
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

3D audio as an information-environment: manipulating perceptual significance for differntiation and pre-selection [PDF]

open access: yes, 2001
Contemporary use of sound as artificial information display is rudimentary, with little 'depth of significance' to facilitate users' selective attention. We believe that this is due to conceptual neglect of 'context' or perceptual background information.
Lennox, Peter   +2 more
core   +1 more source

Quantifying Aspect Bias in Ordinal Ratings using a Bayesian Approach [PDF]

open access: yes, 2017
User opinions expressed in the form of ratings can influence an individual's view of an item. However, the true quality of an item is often obfuscated by user biases, and it is not obvious from the observed ratings the importance different users place on
Hsu, Wynne, Lee, Mong Li, Poddar, Lahari
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Análise espacial das condições térmicas do ambiente pré-ordenha de bovinos leiteiros sob regimes de climatização Spatial analysis of thermal conditions of the pre-milking dairy cattle under climatization regimes

open access: yesRevista Brasileira de Engenharia Agrícola e Ambiental, 2012
Propõe-se, com este trabalho, caracterizar a variabilidade espacial da temperatura do ar na sala de pré-ordenha a partir de diferentes tempos de operação do sistema de resfriamento adiabático evaporativo automatizado.
Irenilson M. da Silva   +5 more
doaj   +1 more source

Physiological responses of caprines raised under different types of covering [PDF]

open access: yesEngenharia Agrícola, 2013
Thermal discomfort inside facilities is one of the factors responsible for low productivity of caprines in the Brazilian Northeast region, because inadequate weather conditions can cause elevated rectal temperature, increased respiratory rate, decreased ...
Celso Y. Kawabata   +4 more
doaj   +1 more source

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