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Ambient Ionization Mass Spectrometry
2014Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject.
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Detection of explosives on skin using ambient ionization mass spectrometry
Chemical Communications, 2007Single nanogram amounts of the explosives TNT, RDX, HMX, PETN and their mixtures were detected and identified in a few seconds on the surface of human skin without any sample preparation by desorption electrospray ionization (DESI) using a spray solution of methanol-water doped with sodium chloride to form the chloride adducts with RDX, HMX, and PETN ...
Dina R, Justes +3 more
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Ambient molecular imaging by desorption electrospray ionization mass spectrometry
Nature Protocols, 2008Desorption electrospray ionization (DESI) allows the direct analysis of ordinary objects or pre-processed samples under ambient conditions. Among other applications, DESI is used to identify and record spatial distributions of lipids and drug molecules in biological tissue sections.
Justin M, Wiseman +3 more
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Coupling corona discharge for ambient extractive ionization mass spectrometry
The Analyst, 2011Unlike the extractive electrospray ionization (EESI) technique described elsewhere, a corona discharge instead of electrospray ionization has been utilized to charge a neutral solvent spray under ambient conditions for the generation of highly charged microdroplets, which impact a neutral sample plume for the extractive ionization of the analytes in ...
Bin, Hu +7 more
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Chemical Aspects of the Extractive Methods of Ambient Ionization Mass Spectrometry
Annual Review of Physical Chemistry, 2013Ambient ionization techniques allow complex chemical samples to be analyzed in their native state with minimal sample preparation. This brings the obvious advantages of simplicity, speed, and versatility to mass spectrometry: Desorption electrospray ionization (DESI), for example, is used in chemical imaging for tumor margin diagnosis.
Abraham K, Badu-Tawiah +3 more
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Recent developments in ambient ionization techniques for analytical mass spectrometry
The Analyst, 2008Ambient ionization techniques enable the interrogation of a variety of samples in their native state by mass spectrometry, and are rapidly advancing all fields where screening for the presence of various analytes in a broadband and/or high-throughput fashion is desirable.
Glenn A, Harris +2 more
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Plasma‐based ambient ionization mass spectrometry in bioanalytical sciences
Mass Spectrometry Reviews, 2015Plasma‐based ambient ionization mass spectrometry techniques are gaining growing interest due to their specific features, such as the need for little or no sample preparation, its high analysis speed, and the ambient experimental conditions. Samples can be analyzed in gas, liquid, or solid forms. These techniques allow for a wide range of applications,
Marek, Smoluch +2 more
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Switched Ferroelectric Plasma Ionizer (SwiFerr) for Ambient Mass Spectrometry
Analytical Chemistry, 2010We present the implementation of a switched ferroelectric plasma ionizer (SwiFerr) for ambient analysis of trace substances by mass spectrometry. The device utilizes the ferroelectric properties of barium titanate (BaTiO(3)) to take advantage of the high electric field resulting from polarization switching in the material.
Neidholdt, Evan L., Beauchamp, J. L.
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Modern machine‐learning applications in ambient ionization mass spectrometry
Mass Spectrometry ReviewsAbstractThis article provides a comprehensive overview of the applications of methods of machine learning (ML) and artificial intelligence (AI) in ambient ionization mass spectrometry (AIMS). AIMS has emerged as a powerful analytical tool in recent years, allowing for rapid and sensitive analysis of various samples without the need for extensive sample
Anatoly A. Sorokin +5 more
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Ambient ionization mass spectrometry as a tool for organic reaction tracking
Analytica Chimica ActaThermal desorption electrospray ionization mass spectrometry (TD-ESI/MS) is an ambient ionization technique that enables the rapid analysis of chemical compounds in solids or solutions. A small amount of the sample solution was placed onto a metal wire, and an electric current was applied to heat it quickly.
Min-Zong Huang +6 more
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