Results 151 to 160 of about 3,769 (208)

Case Report: Clinical case analysis of gaucher disease management in a resource-limited setting: a single center experience from Kashigar, Xinjiang Uygur Autonomous Region, the Western China. [PDF]

Front Pediatr
Maimaititusvn G, Kulaixi M, Atawula A, Liu F.   +3 more
europepmc   +1 more source

Ambroxol as a Treatment for Parkinson Disease Dementia: A Randomized Clinical Trial.

JAMA Neurol
Silveira CRA, Coleman KKL, Borron K, Tirona RG, Rupar CA, Zou G, Hegele RA, Wellington C, Stukas S, Finger EC, Bartha R, Morrow SA, Wells JL, Borrie MJ, Mahuran D, MacDonald PA, Jenkins ME, Jog MS, Dresser G, Fox S, Camicioli R, Feagan B, Mendonça DA, Mayich M, Sharma MD, Pandey SK, Pasternak SH.   +26 more
europepmc   +1 more source

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Antioxidant Properties of Ambroxol

Free Radical Biology and Medicine, 1994
We tested whether Ambroxol, a drug which stimulates the release of surfactant by pneumocytes type II, may also possess antioxidant properties. To assess the reactivity of Ambroxol with reactive oxygen species, we analysed its ability to decompose hydrogen peroxide (H2O2) and to inhibit the superoxide (O2.-)-dependent autooxidation of pyrogallol ...
Dariusz Nowak, Piotr Białasiewicz, Tadeusz Pietras   +2 more
exaly   +3 more sources

Oral Ambroxol Increases Brain Glucocerebrosidase Activity in a Nonhuman Primate [PDF]

Synapse, 2017
Mutations in the glucocerebrosidase 1 (GBA1) gene are related to both Parkinson disease (PD) and Gaucher disease (GD). In both cases, the condition is associated with deficiency of glucocerebrosidase (GCase), the enzyme encoded by GBA1.
Anna Migdalska-Richards, Erwan Bezard
exaly   +3 more sources

Effect of Ambroxol of Neutrophil Chemotaxisin Vitro

Agents and Actions, 1988
Ambroxol hydrochloride has been shown to protect the lung from damage by polymorphonuclear leucocyte (PMN). In view of this observation we have studied the effect of Ambroxol on PMN chemotaxis using a variety of chemoattractants. The PMN response was inhibited 50-80% by preincubating the cells with concentrations of 10(-4) M Ambroxol.
D Burnett
exaly   +3 more sources

Ambroxol in the 21st Century: Pharmacological and Clinical Update

Expert Opinion on Drug Metabolism and Toxicology, 2008
Background: Belonging to the group of expectorants, ambroxol is an active substance with a long history that influences parameters considered to be the basis for the physiological production and the transport of the bronchial mucus. Therefore, ambroxol's
Mario Malerba
exaly   +2 more sources

Ambroxol Is a Scavenger of Hypochlorous Acid and Monochloramine

Pharmacology, 2008
Experimental studies have suggested that ambroxol, a drug clinically used to enhance pulmonary surfactant production, may also exert some anti-inflammatory effects, though specific mechanisms are not yet fully understood. Thus, potential scavenging properties of ambroxol towards the most toxic neutrophil-arising prooxidants hypochlorous acid and ...
LAPENNA, Domenico, de Gioia S, CIOFANI, Giuliano, CUCCURULLO, Franco   +3 more
openaire   +3 more sources

A Controlled Trial of Ambroxol in Chronic Bronchitis

Chest, 1987
Ambroxol is a mucolytic agent which is widely used in chronic bronchitis in Europe. We conducted a double-blind randomized controlled trial of ambroxol vs matched placebo in 90 patients with chronic bronchitis and difficulty clearing secretions. It was concluded that there was no advantage to taking ambroxol.
G H, Guyatt, M, Townsend, F, Kazim, M T, Newhouse   +3 more
openaire   +2 more sources

Ambroxol-Induced Focal Epileptic Seizure

Clinical Neuropharmacology, 2014
It is well known that in epileptic patients some compounds and different drugs used for the treatment of comorbidities can facilitate or provoke seizures, this evidence regarding a wide spectrum of pharmacological categories. The potential facilitating factors usually include direct toxic effects or pharmacological interactions of either active ...
LAPENTA, Leonardo, MORANO, ALESSANDRA, FATTOUCH, JINANE, CASCIATO, SARA, FANELLA, MARTINA, GIALLONARDO, Anna Teresa, Carlo Di Bonaventura   +6 more
openaire   +2 more sources

Sonolytic debromination of ambroxol process wastewater

Water Research, 2003
In this study ultrasound was examined in terms of its effectiveness in treating wastewater containing ambroxol and process water from ambroxol synthesis. The organic bromine contents of the water samples investigated were in the 20-1200 mg l(-1) range. Ultrasound is capable to debrominate the ambroxol molecule rendering it biologically degradable.
Holger, Brüggemann, Heinz, Köser, Erich, Meyer, Thang-Hoang, Nguyen   +3 more
openaire   +2 more sources