Results 21 to 30 of about 1,655 (166)

Ambroxol hydrochloride in the management of idiopathic pulmonary fibrosis: Clinical trials are the need of the hour

Lung India, 2014
Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease of unknown etiology. Its pathogenesis remains poorly elucidated but aberrant wound healing is central to its pathology. It has a median survival time of 3 to 5 years.
P R Gupta
doaj   +2 more sources

Product Development of High-Dose Ambroxol HCl Capsules for an n-of-1 Clinical Trial Involving Dutch Patients with Gaucher Disease Type 3 [PDF]

Pharmaceutics
Background/Objectives: Ambroxol hydrochloride (AMB) is a promising chaperone for treating neurological manifestations in Gaucher disease type 3 (GD3). The Amsterdam University Medical Center planned to conduct an n-of-1 clinical trial using high-dose AMB
Hoang Lan Le, Natalja Bouwhuis, Carla E. M. Hollak, Abraham J. Wilhelm, Anne-Loes E. Gerards, Yuma A. Bijleveld, Eleonora L. Swart   +6 more
doaj   +2 more sources

The safety, tolerability, pharmacokinetics, and pharmacodynamics of nebulized pegylated interferon α-2b in healthy adults: a randomized phase 1 trial [PDF]

BMC Pharmacology and Toxicology
Background Interferons (IFNs) are proteins that combat viruses and regulate the immune system. Studies have demonstrated that aerosol inhalation of IFNα is both effective and safe for treating respiratory infections.
Wenqi Huang, Yanneng Kang, Yajun Zhao, Jiao Yang, Changjuan Dai, Weibing Wu, Jinchao Xu, Wen Jin, Xiaolu Wu, Qing Zhou   +9 more
doaj   +2 more sources

Ambroxol: A potential therapeutics against neurodegeneration

Health Sciences Review, 2023
Ambroxol hydrochloride is a pharmacological chaperone approved by FDA as an expectorant. Currently, it is used as an antitussive and anti-asthmatic agent.
Prajwal Dhanve, Punita Aggarwal, Sourabh Choure, Devendra K. Dhaked, Sugato Banerjee   +4 more
doaj   +1 more source

Cross linked plantain starch-urea as a polymer in matrix tablets of ambroxol hydrochloride

British Journal of Pharmacy, 2021
Plantain (Musa paradisiaca) starch, prepared as crosslinked starch-urea (CSU), was utilized in the formulation of matrix tablets of ambroxol hydrochloride.
Adenike Okunlola, Adenike Temitayo Adedeji   +1 more
doaj   +1 more source

Validasi Metode Analisis Klorfeniramin Maleat Dan Guaifenesin Menggunakan Kromatografi Cair Kinerja Tinggi Serta Aplikasinya Dalam Sediaan Sirup [PDF]

, 2017
The combination of CTM and GG is often used as an active substances to relieve symptoms of cough and cold. The concentration of CTM and GG in syrup are very low, so that it need validated determination method to ensure therapeutic dose. The purposes of
Afifah, I. (Ira), Budiarti, A. (Aqnes)
core   +5 more sources

A quality-by-design eco-friendly UV-HPLC method for the determination of four drugs used to treat symptoms of common cold and COVID-19

Scientific Reports, 2023
An optimization approach based on full factorial design was employed for developing an HPLC–UV method for simultaneous determination of a quaternary mixture used for the treatment of symptoms related to common cold and COVID-19. The quaternary mixture is
Nora A. Abdallah, Mona E. Fathy, Manar M. Tolba, Amina M. El-Brashy, Fawzia A. Ibrahim   +4 more
doaj   +1 more source

Evaluation of safety and efficacy of inhaled ambroxol in hospitalized adult patients with mucopurulent sputum and expectoration difficulty

Frontiers in Medicine, 2023
BackgroundAmbroxol is a widely used mucoactive drug in sputum clearance of respiratory diseases taken orally and by injection. However, there is a paucity of evidence for inhaled ambroxol in sputum clearance.MethodsThis study performed a multicenter ...
Zeguang Zheng, Kai Yang, Ni Liu, Xiuhua Fu, Huijie He, Hong Chen, Peijun Xu, Jing Wang, Maofeng Liu, Yuling Tang, Fengzi Zhao, Shufeng Xu, Xiaowei Yu, Jichang Han, Bo Yuan, Bin Jia, Guifen Pang, Yantong Shi, Min Kuang, Haiyan Shao, Hao Xiong, Jia He, Yuanyuan Pan, Rongchang Chen   +23 more
doaj   +1 more source

Flow injection analysis using carbon film resistor electrodes for amperometric determination of ambroxol [PDF]

, 2008
Flow injection analysis (FIA) using a carbon film sensor for amperometric detection was explored for ambroxol analysis in pharmaceutical formulations.
Angnes, Lúcio, Brett, Christopher M. A., Felix, Fabiana S.   +2 more
core   +1 more source

Biodegradable Chitosan-Based Ambroxol Hydrochloride Microspheres: Effect of Cross-Linking Agents [PDF]

Journal of Young Pharmacists, 2011
The objective of this study was to investigate the influence of type of cross-linking method used on the properties of ambroxol hydrochloride microspheres such as encapsulation efficiency, particle size, and drug release. Microspheres were prepared by solvent evaporation technique using chitosan as a matrix-forming agent and cross-linked using ...
Gangurde, HH, Chavan, NV, Mundada, AS, Derle, DV, Tamizharasi, S   +4 more
openaire   +2 more sources