Results 1 to 10 of about 6,114 (221)

Epiprofin Transcriptional Activation Promotes Ameloblast Induction From Mouse Induced Pluripotent Stem Cells via the BMP-Smad Signaling Axis

Frontiers in Bioengineering and Biotechnology, 2022
The transcriptional regulation of induced pluripotent stem cells (iPSCs) holds promise for their directed differentiation into ameloblasts, which are usually lost after tooth eruption.
Xinchao Miao, Xinchao Miao, Kunimichi Niibe, Yunyu Fu, Maolin Zhang, Maolin Zhang, Praphawi Nattasit, Yumi Ohori-Morita, Takashi Nakamura, Xinquan Jiang, Hiroshi Egusa, Hiroshi Egusa   +11 more
doaj   +2 more sources

PER2-mediated ameloblast differentiation via PPARγ/AKT1/β-catenin axis

International Journal of Oral Science, 2021
Circadian rhythm is involved in the development and diseases of many tissues. However, as an essential environmental regulating factor, its effect on amelogenesis has not been fully elucidated.
Wushuang Huang, Xueqing Zheng, Mei Yang, Ruiqi Li, Yaling Song   +4 more
doaj   +2 more sources

Stage-Specific Role of Amelx Activation in Stepwise Ameloblast Induction from Mouse Induced Pluripotent Stem Cells

International Journal of Molecular Sciences, 2021
Amelogenin comprises ~90% of enamel proteins; however, the involvement of Amelx transcriptional activation in regulating ameloblast differentiation from induced pluripotent stem cells (iPSCs) remains unknown.
Xinchao Miao, Kunimichi Niibe, Maolin Zhang   +2 more
exaly   +2 more sources

A novel Ambn-IRESCre mouse line allows ameloblast-specific Smad4 silencing [PDF]

Frontiers in Physiology
IntroductionFor more than two decades, enamel researchers have primarily used the keratin-14-Cre (Krt14-Cre) driver line to study ameloblast-specific molecular activities.
Rucha Arun Bapat, Yanbin Ji, Marziyeh Aghazadeh, Alexis E. Bauer, David C. Evans, Joseph G. Hacia, Yan Zhou, Yan Zhou, Michael L. Paine, Michael L. Paine   +9 more
doaj   +2 more sources

Odontogenesis-associated phosphoprotein (ODAPH) Promotes Ameloblast adhesion and alkaline phosphatase (ALP) expression via LAMC2/ ITGB6/TGF-β1 signaling pathway. [PDF]

PLoS ONE
Recessive hypomineralized amelogenesis imperfecta has been linked to mutations in Odontogenesis-Associated Phosphoprotein (ODAPH). Consistent with human phenotypes, Odaph-null mice exhibit defective enamel mineralization with ameloblast detachment from ...
Mingyue Li, Jie Zhang, Shuang Xiao, Xinyang Liu, Shuai Song, Xiaoyuan Ye, Ruonan Bi, Yuguang Gao, Li Zhang   +8 more
doaj   +2 more sources

Msx2 in ameloblast cell fate and activity

Frontiers in Physiology, 2015
While many effectors have been identified in enamel matrix and cells via genetic studies, physiological networks underlying their expression levels and thus the natural spectrum of enamel thickness and degree of mineralization are now just emerging ...
Sylvie eBabajko, Sylvie eBabajko, Sylvie eBabajko, Sylvie eBabajko, Muriel ede La Dure-Molla, Muriel ede La Dure-Molla, Muriel ede La Dure-Molla, Muriel ede La Dure-Molla, Muriel ede La Dure-Molla, Katia eJedeon, Katia eJedeon, Katia eJedeon, Katia eJedeon, Ariane eBerdal, Ariane eBerdal, Ariane eBerdal, Ariane eBerdal, Ariane eBerdal   +17 more
doaj   +2 more sources

Comparison of Two Mouse Ameloblast-like Cell Lines for Enamel-specific Gene Expression

Frontiers in Physiology, 2014
Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that mineralizes to form enamel. The development and use of immortalized cell lines, with a stable phenotype, is an important contribution to biological studies as it ...
Juni eSarkar, Emil eSimanian, Sarah eTuggy, John D Bartlett, Malcolm L. Snead, Toshihiro eSugiyama, Michael Lansdell Paine   +6 more
doaj   +2 more sources

Rho GTPases in ameloblast differentiation

Japanese Dental Science Review, 2016
During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial–mesenchymal interaction and a cell-autonomous gene network.
Keishi Otsu, Hidemitsu Harada
doaj   +2 more sources

The role of the TGF-β1 signaling pathway in the process of amelogenesis [PDF]

Frontiers in Physiology
Amelogenesis is a highly regulated process involving multiple signaling pathways, among which the transforming growth factor-β1 (TGF-β1) signaling pathway plays a pivotal role in enamel formation.
Xiaoxue Ma, Yunjing Ma, Zhiyong Lin, Mei Ji   +3 more
doaj   +2 more sources

Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation.

PLoS ONE, 2016
Tooth morphogenesis is initiated by reciprocal interactions between the ectoderm and neural crest-derived mesenchyme, and the Wnt signaling pathway is involved in this process.
Kanako Miyazaki, Keigo Yoshizaki, Chieko Arai, Aya Yamada, Kan Saito, Masaki Ishikawa, Han Xue, Keita Funada, Naoto Haruyama, Yoshihiko Yamada, Satoshi Fukumoto, Ichiro Takahashi   +11 more
doaj   +2 more sources