Results 51 to 60 of about 3,701 (166)

Odontogenesis-associated phosphoprotein truncation blocks ameloblast transition into maturation in Odaph C41*/C41* mice

Scientific Reports, 2021
Mutations of Odontogenesis-Associated Phosphoprotein (ODAPH, OMIM *614829) cause autosomal recessive amelogenesis imperfecta, however, the function of ODAPH during amelogenesis is unknown.
Tian Liang, Yuanyuan Hu, Kazuhiko Kawasaki, Hong Zhang, Chuhua Zhang, Thomas L. Saunders, James P. Simmer, Jan C.-C. Hu   +7 more
doaj   +1 more source

Dental enamel hypoplasia and intra‐tooth isotope records as indicators of physiological stress and environmental variability in Early Pleistocene hippopotamids from Melka Kunture (Upper Awash, Ethiopia)

Journal of Quaternary Science, EarlyView.
ABSTRACT Enamel hypoplasia results from temporary disruptions of enamel deposition during tooth development. It is widely used as an indicator of physiological stress in archeological and paleontological contexts; yet, its relationship with environmental conditions during tooth formation remains poorly constrained.
Giuseppe Briatico, Denis Geraads, Rita T. Melis, Margherita Mussi   +3 more
wiley   +1 more source

Evidence That Calcium Entry Into Calcium-Transporting Dental Enamel Cells Is Regulated by Cholecystokinin, Acetylcholine and ATP

Frontiers in Physiology, 2018
Dental enamel is formed by specialized epithelial cells which handle large quantities of Ca2+ while producing the most highly mineralized tissue. However, the mechanisms used by enamel cells to handle bulk Ca2+ safely remain unclear.
Meerim K. Nurbaeva, Miriam Eckstein, Arun Devotta, Jean-Pierre Saint-Jeannet, David I. Yule, Michael J. Hubbard, Rodrigo S. Lacruz   +6 more
doaj   +1 more source

WDR72 Drives Esophageal Squamous Cell Carcinoma Progression by Inhibiting Autophagy via the PI3K/Akt/mTOR Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with a high rate of recurrence and metastasis, necessitating the identification of novel therapeutic targets. WD repeat‐containing protein 72 (WDR72) has been linked to various cancers, but its specific biological function and underlying mechanism in ESCC remain largely ...
Hao Wu, Zhong‐Xiang Jiang, Zheng Jiang
wiley   +1 more source

Phosphorylated and Non-phosphorylated Leucine Rich Amelogenin Peptide Differentially Affect Ameloblast Mineralization

Frontiers in Physiology, 2018
The Leucine Rich Amelogenin Peptide (LRAP) is a product of alternative splicing of the amelogenin gene. As full length amelogenin, LRAP has been shown, in precipitation experiments, to regulate hydroxyapatite (HAP) crystal formation depending on its ...
Elvire Le Norcy, Elvire Le Norcy, Julie Lesieur, Jeremy Sadoine, Gaël Y. Rochefort, Catherine Chaussain, Catherine Chaussain, Anne Poliard   +7 more
doaj   +1 more source

Energy metabolic shift contributes to the phenotype modulation of maturation stage ameloblasts

Frontiers in Physiology, 2022
Maturation stage ameloblasts (M-ABs) are responsible for terminal enamel mineralization in teeth and undergo characteristic cyclic changes in both morphology and function between ruffle-ended ameloblasts (RA) and smooth-ended ameloblasts (SA).
Haruno Arai, Haruno Arai, Akira Inaba, Akira Inaba, Shojiro Ikezaki, Mika Kumakami-Sakano, Marii Azumane, Marii Azumane, Hayato Ohshima, Kazumasa Morikawa, Hidemitsu Harada, Keishi Otsu   +11 more
doaj   +1 more source

Histological analysis of incremental markings and crown growth characteristics in mandibular first molars of the red fox, Vulpes vulpes (Canidae, Mammalia)

Journal of Anatomy, EarlyView.
This paper histologically analyzed incremental markings in dental enamel of red fox and grey wolf. Our results demonstrate that previous studies have misidentified these markings, which led to miscalculation of dental growth parameters. Abstract The present study analyzed incremental markings in the enamel of eight mandibular first molars (M1) of red ...
Horst Kierdorf, Uwe Kierdorf
wiley   +1 more source

The crucial role of centrioles in tooth growth and development

Journal of the Formosan Medical Association
Background: Tooth development hinged on reciprocal interactions between enamel and dentin, shaping tooth structures. Centrioles influenced cellular direction, critical for stem cell differentiation.
Shan-Li Pei, Rung-Shu Chen, Min-Huey Chen   +2 more
doaj   +1 more source

WDR72 regulates vesicle trafficking in ameloblasts

Scientific Reports, 2022
As the hardest tissue in the human body, tooth enamel formation is a highly regulated process involving several stages of differentiation and key regulatory genes.
Kaitlin Katsura, Yukiko Nakano, Yan Zhang, Rozana Shemirani, Wu Li, Pamela Den Besten   +5 more
doaj   +1 more source

Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories

Journal of Periodontal Research, EarlyView.
This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana Shaddox   +3 more
wiley   +1 more source