Results 61 to 70 of about 3,701 (166)

Protocol for generating three-dimensional induced early ameloblasts using serum-free media and growth factors

STAR Protocols
Summary: Adult humans cannot regenerate the enamel-forming cell type, ameloblasts. Hence, human induced pluripotent stem cell (hiPSC)-derived ameloblasts are valuable for investigating tooth development and regeneration.
Ammar Alghadeer, Anjali P. Patni, Zicong Li, Yen Chian Lim, Julie Mathieu, Hannele Ruohola-Baker   +5 more
doaj   +1 more source

BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. [PDF]

PLoS ONE, 2012
Mouse incisors grow continuously throughout life with enamel deposition uniquely on the outer, or labial, side of the tooth. Asymmetric enamel deposition is due to the presence of enamel-secreting ameloblasts exclusively within the labial epithelium of ...
Kateryna Kyrylkova, Sergiy Kyryachenko, Brian Biehs, Ophir Klein, Chrissa Kioussi, Mark Leid   +5 more
doaj   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

The Evolutionary Young Actin Nucleator Cobl Is Important for Proper Amelogenesis

Cells
The actin cytoskeleton plays an important role in morphological changes of ameloblasts during the formation of enamel, which is indispensable for teeth to withstand wear, fracture and caries progression.
Hannes Janitzek, Jule González Delgado, Natja Haag, Eric Seemann, Sandor Nietzsche, Bernd Sigusch, Britta Qualmann, Michael Manfred Kessels   +7 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Rho GTPases in ameloblast differentiation

Japanese Dental Science Review, 2016
During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial–mesenchymal interaction and a cell-autonomous gene network.
Keishi Otsu, Hidemitsu Harada
doaj   +1 more source

Fluoride as a Modifier of Metallome Homeostasis: A Systematic Review of Animal Studies

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Fluoride is widely used for caries prevention due to its effects on mineralized tissues, yet its potential role as a modifier of systemic metal homeostasis remains insufficiently explored. This systematic review synthesizes preclinical evidence on the association between fluoride exposure and changes in metal and semi‐metal concentrations ...
Natalia Macedo‐Ribeiro, Jonas Tostes‐Figueiredo, Davi da Silva Barbirato, Isabel Maria Porto, Eliude Barbosa Gomes, Erico Marlon Moraes Flores, Marília Afonso Rabelo Buzalaf, Fernando Barbosa Jr, Raquel Fernanda Gerlach   +8 more
wiley   +1 more source

Calcium Sets the Clock in Ameloblasts

Frontiers in Physiology, 2020
BackgroundStromal interaction molecule 1 (STIM1) is one of the main components of the store operated Ca2+ entry (SOCE) signaling pathway. Individuals with mutated STIM1 present severely hypomineralized enamel characterized as amelogenesis imperfecta (AI)
Raed Said, Raed Said, Liubov Lobanova, Silvana Papagerakis, Petros Papagerakis, Petros Papagerakis   +5 more
doaj   +1 more source

Precautions When Extracting Impacted Third Molars With Impacted Enamel Pearls in the Maxillary Sinus Floor: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Cone‐beam computed tomography (CBCT) is routinely used before mandibular wisdom tooth extraction to determine its three‐dimensional relationship with the mandibular canal. In contrast, the extraction of a maxillary third molar is often planned based on panoramic radiographs alone.
Hideki Suito, Yuuri Oku, Tomoyuki Kondo, Kumiko Kamada, Naito Kurio, Naoki Maeda   +5 more
wiley   +1 more source

Modeling the Histogenetic Switch Between Enameloid and Enamel

Evolution &Development, Volume 28, Issue 3, September 2026.
This evo–devo exploration of ~550,000 histogenetic simulations forming dentine, enameloid, and enamel identifies 38 independent ways to induce the enameloid–enamel transition, with delayed matrix vesicle secretion (SVO‐) emerging as the key modification, providing new insights into the origin of enamel in early osteichthyans.
Guillaume Houée, Jérémie Bardin, Damien Germain, Nicolas Goudemand   +3 more
wiley   +1 more source