Results 81 to 90 of about 17,061,900 (337)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Dilemma of Being American as a Consequence of Ethnic Segregation in Toni Morrison's Beloved

Rainbow: Journal of Literature, Linguistics and Culture, 2019
Slavery was a central institution in American society and was accepted as normal and applauded as a positive thing by many white Americans. America was full of Negro slaves when there were many injustice actions done by white people to black people ...
Novia Sekar Ayuningtyas, Mohamad Ikhwan Rosyidi   +1 more
doaj   +1 more source

Asian Americans respond less favorably to excitement (vs. calm)-focused physicians compared to European Americans [PDF]

, 2018
OBJECTIVES: Despite being considered a model minority, Asian Americans report worse health care encounters than do European Americans. This may be due to affective mismatches between Asian American patients and their European American physicians.
Fung, Helene, Jiang, Da, Koopmann-Holm, Birgit, Sims, Tamara, Tsai, Jeanne L., Young, Henry   +5 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

INTELLIGENCE ANALYSIS AND THE CIA – A HISTORICAL PERSPECTIVE: THE FOUR SUBSTANTIAL COMPONENTS OF THE DIRECTORATE OF INTELLIGENCE IN THE DAYS OF THE OFFICE OF NATIONAL ESTIMATES (1950 – 1973) [PDF]

Romanian Intelligence Studies Review
The early 1950s brought significant changes in the internal organization of the CIA, as a result of problematic issues, limitations, and deficiencies that were noted in reports evaluating the Agency’s work. The most important changes have been in the CIA’
Dan ROMAN
doaj  

SALT Equalizer, Vol. 2015, Issue 2

, 2015
Contents of This Issue: 2016 SALT Annual Dinner, at 1. 2016 SALT Annual Dinner Sponsors, at 2. Olympia Duhart & Ruben Garcia, Co-Presidents’ Column, at 2. SALT Membership: Reduced Rates, Online Renewal, at 3. SALT Files Amicus Brief Supporting University
Society of American Law Teachers
core   +1 more source

1 1/2 Years in Death Valley [PDF]

, 2013
This paper is an exploration into the historian as an independent source of history. Homer T. Rosenberger was an amateur historian in Pennsylvania during the better part of the 20th century.
Gentilucci, Louis T.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Decline of the North American avifauna

Science, 2019
Staggering decline of bird populations Because birds are conspicuous and easy to identify and count, reliable records of their occurrence have been gathered over many decades in many parts of the world.
K. Rosenberg, A. Dokter, P. Blancher, J. Sauer, Adam C. Smith, P. Smith, J. Stanton, A. Panjabi, Laura Helft, M. Parr, P. Marra   +10 more
semanticscholar   +1 more source