Results 51 to 60 of about 2,929,236 (305)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Symposium: Redefinitions of Citizenship and Revisions of Cosmopolitanism—Transnational Perspectives
Journal of Transnational American Studies, 2011 The following set of essays consists of revised versions of contributions read at, or prepared for, a roundtable discussion at the 2009 convention of the American Studies Association in Washington, DC.
Günter H. Lenz +4 more
doaj +1 more source
The Perpetual Invasion : Past as Prologue in Constitutional Immigration Law [PDF]
, 2018 Donald Trump ascended to the presidency largely on the promise to protect the American people—their physical and financial security, their culture and language, even the integrity of their electoral system—against an invading foreign menace.
Lindsay, Matthew J
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Frontiers in Education, 2020 Informal learning institutions, such as museums, science centers, and community-based organizations, play a critical role in providing opportunities for students to engage in science, technology, engineering, and mathematics (STEM) activities during out ...
Bobby Habig, Bobby Habig
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A Biogeographic History of the Plains Bison Focusing on Population and Range Dynamics [PDF]
, 2015 Early bison originated in Asia and migrated to North America by means of the Bering Land Bridge, which opened around 600,000 years ago. Just after the Wisconsin glaciation (11, 700 years ago), there were two allopatric species of bison residing in North ...
Roman, Grace
core +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Review and Interpretation of Trends in DNA Barcoding
Frontiers in Ecology and Evolution, 2019 Interpretations and analytical practices surrounding DNA barcoding are examined using a compilation of 3,756 papers (as of December 31, 2018) with “DNA Barcode” in the abstract published since 2004.
Rob DeSalle, Paul Goldstein
doaj +1 more source
A study of the Central American Common Market [PDF]
, 1965 In the history of the Central American Republics many attempts at union, either political or economic or both, have been made and all have failed. Presently, these same countries are united economically once again as the Central American Common Market.
Harnad, Paul K., Olsen, Robert M.
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