Results 71 to 80 of about 1,152,115 (263)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Looking for Kunta Kinte: Alex Haley's Roots and African American Genealogies

Iperstoria, 2014
As the 30th anniversary 2006 edition recalls, Alex Haley’s Roots: The Saga of an American Family was a big popular success: in 1976, the year it was published, “the book sold over one million copies” and in 1977 the miniseries created out of it “was ...
Elisa Bordin
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Remediating the remediated : printed prose in the age of hypertext

Acta Neophilologica, 2006
The article argues that with the spreading of computer hypertext into the social sphere, hypertext is no longer merely a writing technique or an organising principle; it becomes the logic implicit in the functioning of postmodern  societies.lts ...
Mojca Krevel
doaj   +1 more source

Parental Involvement in the Transition from Paediatric to Adult Care for Youth with Chronic Illness: A Scoping Review of the North American Literature. [PDF]

Int J Pediatr, 2023
Badour B, Bull A, Gupta AA, Mirza RM, Klinger CA.   +4 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Introduction

RSA Journal, 2015
Introduction to the Special Section “American Life and Literature into Film”
Gianfranca Balestra
doaj   +1 more source

Contemporary american literature in Online Learning: fostering Reading Motivation and Student Engagement. [PDF]

Educ Inf Technol (Dordr), 2023
Gao L.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Introduction to American Literature in the World

Journal of Transnational American Studies, 2017
Wai Chee Dimock, introduction to American Literature in the World: An Anthology from Anne Bradstreet to Octavia Butler, ed. Wai Chee Dimock et al. (New York: Columbia University Press, 2017), 1–18.
Wai Chee Dimock
doaj   +1 more source