Modular Synthesis of Bicyclic Twisted Amides and Anilines [PDF]
, 2023 Bridged amides and anilines display interesting properties owing to perturbation of conjugation of the nitrogen lone-pair with the adjacent π-system.
Alexandra, Hindle +6 more
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Tandem Triphosgene-Assisted Metal-Free One-pot Preparation of Nitriles and Amides from Aldehydes and Ketones [PDF]
, 2021 Here we report a facile and efficient triphosgene-assisted one-pot conversion of aldehydes/ketones into nitriles/amides. The triphosgene, a kind of phosgene alternative, containing both ester linkage and chloromethyl units, easily reacts with oximes for ...
Jianguo, liu, Xiu-Zhi, Wei, Longlong, Ma
core +1 more source
Introducing N-X Anomeric Amides: Powerful Electrophilic Halogenation Reagents [PDF]
, 2023 Electrophilic halogenation is a widely-used tool employed by medicinal chemists to either pre-functionalize molecules for further diversity or incorporate a halogen atom in drugs or drug-like compounds to solve metabolic problems or modulate off-target ...
Doris, Chen +16 more
core +2 more sources
Reduction of Secondary Amides to Imines Catalysed by Schwartz’s Reagent [PDF]
, 2022 The partial reduction of amides is a challenging transformation that must overcome the intrinsic stability of the amide bond, a ubiquitous motif in organic chemistry, and exhibit high chemoselective control.
Liam, Donnelly +2 more
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Chemoselective α‑Sulfidation of Amides Using Sulfoxide Reagents [PDF]
, 2020 The direct α-sulfidation of tertiary amides using sulfoxide reagents under electrophilic amide activation conditions is described. Employing convenient and readily available reagents, selective functionalization takes place to generate isolable sulfonium
Movassaghi, Mohammad +5 more
core +3 more sources
Mild Divergent Semi-Reductive Transformations of Secondary and Tertiary Amides via Zirconocene Hydride Catalysis [PDF]
, 2022 The mild catalytic partial reduction of amides to imines has proven to be a challenging synthetic transformation, with many transition metals directly reducing these substrates to amines.
Rebecca, Kehner +2 more
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Enantioselective Hydroalkylation of α,β-Unsaturated Amides through Reversed syn-Hydrometallation of NiH [PDF]
, 2021 Enantioselective synthesis of a wide range of structurally diverse β-chiral amides has been achieved through nickel-catalyzed regio-reversed hydroalkylation of α,β-unsaturated amides with alkyl iodides in the presence of a hydrosilane. Different from the
Fang, Zhou, Shaolin, Zhu
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Adsorption of alkyl amides: monolayer structures and mixing behaviour [PDF]
, 2011 In this work monolayers of alkyl amides adsorbed on a graphite surface have been successfully identified and investigated using a combination of synchrotron X-ray and neutron diffraction and Differential Scanning Calorimetry (DSC).
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Mechanochemical Synthesis of Primary Amides [PDF]
, 2021 CRUE-CSIC (Acuerdos Transformativos 2021)Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride afforded the corresponding primary amides in a transformation that was compatible with a variety of ...
Gómez-Carpintero Jiménez, Jorge +3 more
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Highly Chemoselective Synthesis of Hindered Amides via Cobalt-Catalyzed Intermolecular Oxidative Hydroamidation [PDF]
, 2020 α-Tertiary amides are of great importance for medicinal chemistry. However, they are often challenging to access through conventional methods due to reactivity and chemoselectivity issues.
Dong-Chen, Ouyang +4 more
core +2 more sources