Results 11 to 20 of about 72,922 (314)

Chemoselective α‑Sulfidation of Amides Using Sulfoxide Reagents [PDF]

, 2020
The direct α-sulfidation of tertiary amides using sulfoxide reagents under electrophilic amide activation conditions is described. Employing convenient and readily available reagents, selective functionalization takes place to generate isolable sulfonium
Movassaghi, Mohammad, Mohammad, Movassaghi, D’Angelo, Kyan A, Leypold, Mario, Mario, Leypold, Kyan A., D’Angelo   +5 more
core   +1 more source

Modular Synthesis of Bicyclic Twisted Amides and Anilines

, 2023
Bridged amides and anilines display interesting properties owing to perturbation of conjugation of the nitrogen lone-pair with the adjacent π-system.
Alexandra, Hindle, Jonathan, Iggo, Christopher, Pask, Stephen, Marsden, Daniel, Cox, Krzysztof, Baj, Adam, Nelson   +6 more
core   +1 more source

Tandem Triphosgene-Assisted Metal-Free One-pot Preparation of Nitriles and Amides from Aldehydes and Ketones

, 2021
Here we report a facile and efficient triphosgene-assisted one-pot conversion of aldehydes/ketones into nitriles/amides. The triphosgene, a kind of phosgene alternative, containing both ester linkage and chloromethyl units, easily reacts with oximes for ...
Jianguo, liu, Xiu-Zhi, Wei, Longlong, Ma
core   +1 more source

5-Chloroisoxazoles: A Versatile Starting Material for the Preparation of Amides, Anhydrides, Esters, and Thioesters of 2H-Azirine-2-carboxylic Acids

Molecules, 2022
Amides, anhydrides, esters, and thioesters of 2H-azirine-2-carboxylic acids were prepared by a rapid procedure at room temperature involving FeCl2-catalyzed isomerization of 5-chloroisoxazoles to 2H-azirine-2-carbonyl chlorides, followed by reaction with
Anastasiya V. Agafonova, Mikhail S. Novikov, Alexander F. Khlebnikov   +2 more
doaj   +1 more source

Amide-Amide and Amide-Water Hydrogen Bonds: Implications for Protein Folding and Stability [PDF]

Journal of the American Chemical Society, 1994
Amide-amide hydrogen bonds have been implicated in directing protein folding and enhancing protein stability. Inversion transfer (13)C NMR spectroscopy and IR spectroscopy were used to compare the ability of various amide solvents and of water to alter the rate of the cis-trans isomerization of the prolyl peptide bond of Ac-Gly-[β,δ-(13)C]Pro-OMe and ...
Eric S, Eberhardt, Ronald T, Raines
openaire   +2 more sources

Synthetic Cinnamides and Cinnamates: Antimicrobial Activity, Mechanism of Action, and In Silico Study

Molecules, 2023
The severity of infectious diseases associated with the resistance of microorganisms to drugs highlights the importance of investigating bioactive compounds with antimicrobial potential.
Mayara Castro de Morais, Edeltrudes de Oliveira Lima, Yunierkis Perez-Castillo, Damião Pergentino de Sousa   +3 more
doaj   +1 more source

Introducing N-X Anomeric Amides: Powerful Electrophilic Halogenation Reagents

, 2023
Electrophilic halogenation is a widely-used tool employed by medicinal chemists to either pre-functionalize molecules for further diversity or incorporate a halogen atom in drugs or drug-like compounds to solve metabolic problems or modulate off-target ...
Doris, Chen, Shasha, Zhang, Phil, Baran, Aris, Vasilopolous, Lacey, Samp, Yu, Wang, Yu, Kawamata, Lauren, Grant, Maximilian, Palkowitz, Jennifer, Qiao, Cheng, Bi, Kaid, Harper, Michael, Collins, Paul, Richardson, Chet, Tyrol, Erik, LaChapelle, Martins, Oderinde   +16 more
core   +1 more source

Reduction of Secondary Amides to Imines Catalysed by Schwartz’s Reagent

, 2022
The partial reduction of amides is a challenging transformation that must overcome the intrinsic stability of the amide bond, a ubiquitous motif in organic chemistry, and exhibit high chemoselective control.
Liam, Donnelly, Thibault , Cantat, Jean-Claude, Berthet   +2 more
core   +1 more source

Mild Divergent Semi-Reductive Transformations of Secondary and Tertiary Amides via Zirconocene Hydride Catalysis

, 2022
The mild catalytic partial reduction of amides to imines has proven to be a challenging synthetic transformation, with many transition metals directly reducing these substrates to amines.
Rebecca, Kehner, Ge, Zhang, Liela, Romero   +2 more
core   +1 more source

An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide

Beilstein Journal of Organic Chemistry, 2013
A self-condensation cyclization reaction mediated by phosphorus pentoxide (P2O5) and catalyzed by zinc bromide (ZnBr2) is presented for the synthesis of polysubstituted 4-pyridones and 2-pyridones from β-keto amides.
Liquan Tan, Peng Zhou, Cui Chen, Weibing Liu   +3 more
doaj   +1 more source