Results 41 to 50 of about 72,922 (314)

Highly Chemoselective Synthesis of Hindered Amides via Cobalt-Catalyzed Intermolecular Oxidative Hydroamidation

, 2020
α-Tertiary amides are of great importance for medicinal chemistry. However, they are often challenging to access through conventional methods due to reactivity and chemoselectivity issues.
Dong-Chen, Ouyang, Rong, Zhu, Rui-Qi, Ding, Yun-Nian, Yin, Qing, Zhang   +4 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Synthesis and anion recognition properties of shape-persistent binaphthyl-containing chiral macrocyclic amides

Beilstein Journal of Organic Chemistry, 2012
We report on the synthesis and characterization of novel shape-persistent, optically active arylamide macrocycles, which can be obtained using a one-pot methodology.
Marco Caricato, Nerea Jordana Leza, Claudia Gargiulli, Giuseppe Gattuso, Daniele Dondi, Dario Pasini   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Direct esterification of amides by the dimethylsulfate-mediated activation of amide C–N bonds

Communications Chemistry
Amides are important intermediates in organic chemistry and the pharmaceutical industry, but their low reactivity requires catalysts and/or severe reaction conditions for esterification.
Hongjian Qin, Zijian Han, Emmanuel Mintah Bonku, Haiguo Sun, Abdullajon Odilov, Fuqiang Zhu, Safomuddin Abduahadi, Weiliang Zhu, Jingshan Shen, Haji A. Aisa   +9 more
doaj   +1 more source

p-Coumaroyl Amides from the Plant Kingdom: A Comprehensive Review of Natural Sources, Biosynthesis, and Biological Activities

Molecules
Hydroxycinnamic acids are widely distributed in the plant kingdom, both as free compounds and as conjugates with other molecules, such as amino acids, carbohydrates, alcohols or amines, and polyamines, forming different derivatives, such as amides ...
Federico Berti, Elena Maria Tamburello, Cristina Forzato   +2 more
doaj   +1 more source

A practical route to tertiary diarylmethylamides or -carbamates from imines, organozinc reagents and acyl chlorides or chloroformates

Beilstein Journal of Organic Chemistry, 2011
A practical route to tertiary diarylmethylamides or -carbamates from imines, organozinc reagents and acyl chlorides or chloroformates is described. This route involves the formation of an imine, which is used without isolation, followed by its activation
Erwan Le Gall, Antoine Pignon, Thierry Martens   +2 more
doaj   +1 more source

The use of isoxazoline and isoxazole scaffolding in the design of novel thiourea and amide liquid-crystalline compounds

Beilstein Journal of Organic Chemistry, 2020
A series of novel thiourea and amide liquid crystals containing 5-membered isoxazoline and isoxazole rings were synthetized and the liquid crystal properties studied.
Itamar L. Gonçalves, Rafaela R. da Rosa, Vera L. Eifler-Lima, Aloir A. Merlo   +3 more
doaj   +1 more source

Regioselective Ortho Halogenation of N-Aryl Amides and Ureas via Oxidative Halodeboronation: Harnessing Boron Reactivity for Efficient C-Halogen Bond Installation

, 2023
The installation of the C-halogen bond to the ortho position of N-aryl amides and ureas represents a tool to prepare motifs that are ubiquitous in biologically active compounds.
Ganesh , Shinde, Ganesh, Ghotekar, Per-Ola, Norrby, Lars, Öhrström, Francoise, Amombo Noa, Henrik, Sundén   +5 more
core   +1 more source