Results 41 to 50 of about 79,537 (266)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Synthesis and anion recognition properties of shape-persistent binaphthyl-containing chiral macrocyclic amides

Beilstein Journal of Organic Chemistry, 2012
We report on the synthesis and characterization of novel shape-persistent, optically active arylamide macrocycles, which can be obtained using a one-pot methodology.
Marco Caricato, Nerea Jordana Leza, Claudia Gargiulli, Giuseppe Gattuso, Daniele Dondi, Dario Pasini   +5 more
doaj   +1 more source

pH Sensitive Anticancer Prodrug: Amide of Kemp's Acid [PDF]

, 2009
Solid tumours are characterised by lower extracellular pH (as low as 5.8 pH) compared to normal healthy cellular pH (actively regulated at pH 7.3). This difference may be exploited with an acid-sensitive anti-tumour prodrug which releases a cytotoxin ...
Brooks, Robert Turongo
core  

Additive-free Pd/In2O3 Catalyzed N-methylation of Primary Amides using Formic Acid [PDF]

Here we report on the use of formic acid as a green and safe reagent for the N-methylation of primary amides in the presence of a Pd/In2O3 solid catalyst.
Caroline, Genre, Idir, Benaissa, Thibault, Cantat, Kassiogé, Dembélé   +3 more
core   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Direct esterification of amides by the dimethylsulfate-mediated activation of amide C–N bonds

Communications Chemistry
Amides are important intermediates in organic chemistry and the pharmaceutical industry, but their low reactivity requires catalysts and/or severe reaction conditions for esterification.
Hongjian Qin, Zijian Han, Emmanuel Mintah Bonku, Haiguo Sun, Abdullajon Odilov, Fuqiang Zhu, Safomuddin Abduahadi, Weiliang Zhu, Jingshan Shen, Haji A. Aisa   +9 more
doaj   +1 more source

p-Coumaroyl Amides from the Plant Kingdom: A Comprehensive Review of Natural Sources, Biosynthesis, and Biological Activities

Molecules
Hydroxycinnamic acids are widely distributed in the plant kingdom, both as free compounds and as conjugates with other molecules, such as amino acids, carbohydrates, alcohols or amines, and polyamines, forming different derivatives, such as amides ...
Federico Berti, Elena Maria Tamburello, Cristina Forzato   +2 more
doaj   +1 more source

A practical route to tertiary diarylmethylamides or -carbamates from imines, organozinc reagents and acyl chlorides or chloroformates

Beilstein Journal of Organic Chemistry, 2011
A practical route to tertiary diarylmethylamides or -carbamates from imines, organozinc reagents and acyl chlorides or chloroformates is described. This route involves the formation of an imine, which is used without isolation, followed by its activation
Erwan Le Gall, Antoine Pignon, Thierry Martens   +2 more
doaj   +1 more source

The use of isoxazoline and isoxazole scaffolding in the design of novel thiourea and amide liquid-crystalline compounds

Beilstein Journal of Organic Chemistry, 2020
A series of novel thiourea and amide liquid crystals containing 5-membered isoxazoline and isoxazole rings were synthetized and the liquid crystal properties studied.
Itamar L. Gonçalves, Rafaela R. da Rosa, Vera L. Eifler-Lima, Aloir A. Merlo   +3 more
doaj   +1 more source