Results 51 to 60 of about 322,084 (409)

Iodoarene-Catalyzed Cyclizations of Unsaturated Amides [PDF]

, 2015
The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route.
Ali Alhalib, Bode H. B., Degnan B. M., Dohi T., Dohi T., Fujita M., Fujita M., Guilbault A.-A., Guilbault A.-A., Hamnett D. J., Kong A., Mizar P., Moon N. G., Murai T., Ngatimin M., Parra A., Richardson R. D., Rodríguez A., Rodríguez A., Shimogaki M., Somaia Kamouka, Suzuki S., Uyanik M., Uyanik M., Wesley J. Moran, Wu H., Yan J., Zhdankin V. V., Zheng Z. S., Zhong W., Zhou Z.-S.   +30 more
core   +1 more source

Enantioselective synthesis of γ-chiral amides via copper-catalyzed reductive relay hydroaminocarbonylation

Nature Communications
Chiral amides are common and effective structural motifs found in many pharmaceuticals and biologically active molecules. Despite their importance, existing synthetic methods are predominantly employed for the synthesis of α-amides and β-amides.
Yang Yuan, Youcan Zhang, Xiao-Feng Wu
doaj   +1 more source

Multi-environment evaluations across ecological regions reveal climate and soil effects on amides contents in Chinese prickly ash peels (Zanthoxylum bungeanum Maxim.)

BMC Plant Biology, 2023
Background Environmental factors difference is the key factor for the difference in the production, transformation and accumulation of effective components in plants.
Tao Zheng, Hai-tao Zeng, Bing-yin Sun, Shu-ming Liu   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Improved nuclear localization of DNA-binding polyamides [PDF]

, 2006
Regulation of endogenous genes by DNA-binding polyamides requires effective nuclear localization. Previous work employing confocal microscopy to study uptake of fluorophore-labeled polyamides has demonstrated the difficulty of predicting a priori the ...
Baird, Belitsky, Belitsky, Best, Bianchi, Claire S. Jacobs, Crowley, Dervan, Dervan, Dervan, Dickinson, Dudouet, Edelson, Foister, Gottesfeld, Juliano, Kaizerman, Kielkopf, Kong, Michelle E. Farkas, Nguyen-Hackley, Nicholas G. Nickols, Olenyuk, Peter B. Dervan, Suto, Trauger, Ueda, Vandyke, White, Wood, Wurtz   +30 more
core   +3 more sources

Enzyme‐Catalysed Synthesis of Secondary and Tertiary Amides

Advanced Synthesis and Catalysis, 2019
The synthesis of the amide bond between an amine and a carboxylic acid is one of the most significant reactions in industrial pharmaceutical synthesis.
M. Petchey, G. Grogan
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Ammonothermal Synthesis and Crystal Structures of Diamminetriamidodizinc Chloride [Zn2(NH3)2(NH2)3]Cl and Diamminemonoamidozinc Bromide [Zn(NH3)2(NH2)]Br

Inorganics, 2016
The treatment of excess zinc in the presence of ammonium chloride under ammonothermal conditions of 873 K and 97 MPa leads to diamminetriamidodizinc chloride [Zn2(NH3)2(NH2)3]Cl with a two-dimensionally μ-amido-interconnected substructure.
Theresia M. M. Richter, Sabine Strobel, Nicolas S. A. Alt, Eberhard Schlücker, Rainer Niewa   +4 more
doaj   +1 more source

Synthesis of indoles via alkylidenation of acyl hydrazides [PDF]

, 2009
Indoles have been synthesised via alkylidenation of acyl phenylhydrazides using phosphoranes and the Petasis reagent, followed by in situ thermal rearrangement of the product enehydrazines.
Commeureuc, A.G.J., EPSRC (Funder), Hisler, K., Murphy, J.A., WestCHEM (Funder), Zhou, S.Z.   +5 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source