Results 101 to 110 of about 31,652 (216)

Podocyte‐Derived Extracellular Vesicles Induce Endothelial Dysfunction by Triggering ER Stress in Glomerular Disease

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Podocyte injury and endothelial cell dysfunction are the hallmarks of glomerular disease. How these two events are connected remains largely unknown. This study aimed to delineate the role of extracellular vesicles (EVs) in mediating podocyte‐endothelial communication in glomerular disease.
Zhao Liu, Xi Liu, Xin Wen, Siyu Yan, Meizhi He, Jie Xu, Zhanji Zhan, Haili Zhu, Huishi Tan, Nan Jia, Youhua Liu   +10 more
wiley   +1 more source

Effects of furosemide, acetazolamide and amiloride on renal cortical and medullary tissue oxygenation in non‐anaesthetised healthy sheep

Experimental Physiology
It has been proposed that diuretics can improve renal tissue oxygenation through inhibition of tubular sodium reabsorption and reduced metabolic demand.
Connie P. C. Ow, Nobuki Okazaki, Naoya Iguchi, Rachel M. Peiris, Roger G. Evans, Sally G. Hood, Clive N. May, Rinaldo Bellomo, Yugeesh R. Lankadeva   +8 more
doaj   +1 more source

Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]

, 2000
Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core   +1 more source

Macromolecule‐Loaded Hybrid Extracellular Vesicles via Ionic Lipid–Based Post‐Loading for Intracellular Delivery: Functional Evaluation for Neurodegenerative Therapy

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Extracellular vesicles (EVs) are natural carriers that show promise as drug delivery systems (DDS). We developed a non‐invasive post‐loading method to encapsulate macromolecules in EVs using our proprietary ionic lipid base (ILB), which enables electrostatically driver hybridisation without disrupting EV structure.
Lin Cui, Fumiyasu Ono, Tomoko Ichinose, Masahiro Goto, Kohei Ishihama   +4 more
wiley   +1 more source

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5‐diamino‐6‐chloro‐N‐(N‐(2,6‐dichlorobenzoyl)carbamimidoyl)pyrazine‐2‐carboxide

Molecular Oncology, 2019
Alternative splicing (AS) is a process that enables the generation of multiple protein isoforms with different biological properties from a single mRNA.
Chien‐Chin Lee, Wen‐Hsin Chang, Ya‐Sian Chang, Jinn‐Moon Yang, Chih‐Shiang Chang, Kai‐Cheng Hsu, Yun‐Ti Chen, Ting‐Yuan Liu, Yu‐Chia Chen, Shyr‐Yi Lin, Yang‐Chang Wu, Jan‐Gowth Chang   +11 more
doaj   +1 more source

Calcium entry via TRPV1 but not ASICs induces neuropeptide release from sensory neurons [PDF]

, 2014
Inflammatory mediators induce neuropeptide release from nociceptive nerve endings and cell bodies, causing increased local blood flow and vascular leakage resulting in edema.
Alijevic, O., Boillat, A., Kellenberger, S.   +2 more
core   +1 more source

Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). [PDF]

, 1979
Madin-Darby canine kidney (MDCK) cells grown in tissue culture have the morphological properties of distal tubular epithelial cells, form tight junctions, and lack several proximal tubular enzyme markers.
Chuman, LM, Rindler, MJ, Saier, MH, Shaffer, L   +3 more
core  

Active Macropinocytosis, Lipid Catabolism, and Exhausting Immune Microenvironment of Ascites Tumor Cells Are Involved in Resistance to Platinum‐Based Therapy in Patients With High‐Grade Serous Ovarian Cancer

MedComm, Volume 7, Issue 3, March 2026.
Platinum‐resistant patients exhibited ascites suffer from immune exhaustion and enriched in lipids, which is used by tumor cells as energy resources to counteract platinum damage through active macropinocytosis and lipid catabolism. These resistant features in ascites can also predict, to a certain extent, the efficacy of platinum‐based therapy in ...
Ruiqi Zheng, Ying Cui, Xun Hu, Xin Dong, Bo Meng, Luhong Wen, Anqi Chen, Zijng Wang, Guifen Qiang, Shujun Cheng, Yang Zhao, Huiqin Guo, Ting Xiao   +12 more
wiley   +1 more source

A Localized Surface Plasmon Resonance Sensing Method for Simultaneous Determination of Atenolol and Amiloride in Pharmaceutical Dosage Forms and Urine Samples

Journal of Analytical Methods in Chemistry, 2018
This contribution describes a simple, fast, and sensitive application of localized surface plasmon resonance effect of silver nanoparticles for simultaneous determination of antihypertensive drugs’ mixture atenolol and amiloride in both pharmaceutical ...
Marwa R. El-Zahry
doaj   +1 more source

GENETIC VARIATION IN CYP4A11 AND BLOOD PRESSURE RESPONSE TO MINERALOCORTICOID RECEPTOR ANTAGONISM OR ENAC INHIBITION: AN EXPLORATORY PILOT STUDY IN AFRICAN AMERICANS [PDF]

, 2014
Background An rs3890011 variant of CYP4A11, which is in linkage disequilibrium with the loss-of-function variant rs1126742, is associated with hypertension in humans. In mice, Cyp4a deficiency results in salt-sensitive hypertension through activation of
Brown, Nancy J., Eckert, George J., Elijovich, Fernando, Laffer, Cheryl L., Pratt, J. Howard, Tu, Wanzhu   +5 more
core   +1 more source