Results 71 to 80 of about 16,803 (187)

Effects of furosemide, acetazolamide and amiloride on renal cortical and medullary tissue oxygenation in non‐anaesthetised healthy sheep

Experimental Physiology
It has been proposed that diuretics can improve renal tissue oxygenation through inhibition of tubular sodium reabsorption and reduced metabolic demand.
Connie P. C. Ow, Nobuki Okazaki, Naoya Iguchi, Rachel M. Peiris, Roger G. Evans, Sally G. Hood, Clive N. May, Rinaldo Bellomo, Yugeesh R. Lankadeva   +8 more
doaj   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik, Hua-Poo Su, Yacob Gomez Llorente, Rachel L. Palte, Daniel J. Klein, Robert P. Hayes, Sadie P. Antine, Guilermo A. Asmar-Rovira, Nicole Bertoletti, Noel J. Byrne, Brittany L. Carroll, Ciro D. Cordeiro, Kaylynn Curfman, James Dutko, Michael J. Eddins, Thierry Fischmann, Barani Govindarajan, Corey W. Hecksel, Thu Ho, Kaspar Hollenstein, Mee Ra Hong, Alan Hruza, Andrii Ishchenko, Maru Jaime-Garza, Matt J. Jaremko, Hayley L. Knox, James Kostas, Harini Krishnamurthy, Ioannis Manolaridis, Cameron L. Noland, Andrea T. Partridge, Sangita B. Patel, Paul Reichert, John C. Reid, Catarina Felisberto-Rodrigues, Chitra A. Shintre, Jennifer M. Shipman, Elakkiya Tamilselvan, Morgan E. Walker, Susanne N. Walker, Renjing Wang, Katharine M. Wright, Tien-Jui Yen, Byung-Kuk Yoo, Sandra B. Gabelli   +44 more
wiley   +1 more source

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5‐diamino‐6‐chloro‐N‐(N‐(2,6‐dichlorobenzoyl)carbamimidoyl)pyrazine‐2‐carboxide

Molecular Oncology, 2019
Alternative splicing (AS) is a process that enables the generation of multiple protein isoforms with different biological properties from a single mRNA.
Chien‐Chin Lee, Wen‐Hsin Chang, Ya‐Sian Chang, Jinn‐Moon Yang, Chih‐Shiang Chang, Kai‐Cheng Hsu, Yun‐Ti Chen, Ting‐Yuan Liu, Yu‐Chia Chen, Shyr‐Yi Lin, Yang‐Chang Wu, Jan‐Gowth Chang   +11 more
doaj   +1 more source

Mechanism of Fluid Reabsorption in Kidney Proximal Tubule: Interplay Between Lateral Na+/K+‐ATPase and AQP1 and SGLT1 Mediated Water Fluxes

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aims The mechanism of isosmotic water reabsorption in the kidney proximal tubule, with a focus on the interaction between the lateral Na+/K+‐ATPase, apical water pathways mediated by AQP1 and SGLT1, and paracellular water flow through Claudin‐2. Methods A mathematical model of proximal tubular transport was used to compute coupled ion, solute,
Erik Hviid Larsen, Jens Nørkær Sørensen   +1 more
wiley   +1 more source

A Localized Surface Plasmon Resonance Sensing Method for Simultaneous Determination of Atenolol and Amiloride in Pharmaceutical Dosage Forms and Urine Samples

Journal of Analytical Methods in Chemistry, 2018
This contribution describes a simple, fast, and sensitive application of localized surface plasmon resonance effect of silver nanoparticles for simultaneous determination of antihypertensive drugs’ mixture atenolol and amiloride in both pharmaceutical ...
Marwa R. El-Zahry
doaj   +1 more source

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Sodium selectivity of semicircular canal duct epithelial cells

BMC Research Notes, 2011
Background Sodium absorption by semicircular canal duct (SCCD) epithelial cells is thought to contribute to the homeostasis of the volume of vestibular endolymph.
Harbidge Donald G, Pondugula Satyanarayana R, Wu Tao, Yamazaki Muneharu, Marcus Daniel C   +4 more
doaj   +1 more source

Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test

Pain Research and Management, 2015
BACKGROUND: Amiloride has been reported to produce a wide variety of actions, thereby affecting several ionic channels and a multitude of receptors and enzymes.
Handong Ouyang, Peizong Wang, Wan Huang, Qiang Li, Bilin Nie, Weian Zeng   +5 more
doaj   +1 more source

Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice

BMC Endocrine Disorders, 2005
Background Amiloride derivatives, commonly used for their diuretic and antihypertensive properties, can also cause a sustained but reversible decrease of intracellular pH (pHi).
Head W Steven, Gunawardana Subhadra C, Piston David W   +2 more
doaj   +1 more source