Results 101 to 110 of about 4,195,373 (294)

Amino Acid Dysmetabolism in Type 2 Diabetes Mellitus: Integrated Analysis of Urinary Chromatography and Serum Amino Acid Profiles

GAIMS Journal of Medical Sciences
Background: Type 2 diabetes mellitus (T2DM) represents a complex metabolic disorder associated with significant disruptions in glucose and amino acid metabolism.
Dinesh Kumar Sharma, Sudama Rathore
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Effect of oxygen deficiency on nitrogen assimilation and amino acid metabolism of soybean root segments

, 2015
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Plants submitted to O-2 deficiency present a series of biochemical modifications, affecting overall root metabolism.
Sodek, L, Oliveira, HC
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Nitrogen metabolism in Corynebacterium glutamicum ATCC 13032 [PDF]

, 2002
Bibliography: leaves 125-146.Corynebacterium glutamicum is extensively used for the commercial production of a host of amino acids including lysine, glutamate, and threonine.
Schulz, Anton A
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Cellular Signaling of Amino Acid Metabolism in Prostate Cancer

Prostate cancer is one of the most common malignancies affecting men worldwide and a leading cause of cancer-related mortality, necessitating a deeper understanding of its underlying biochemical pathways. Similar to other cancer types, prostate cancer is
Yawen Guo, Wenken Liang, Ping Yao, Ziang Zhu, Jianling Xie, Shiqi Cao, Yunru Wen   +6 more
core   +1 more source

Metabolic changes in summer active and anuric hibernating free-ranging brown bears (ursus arctos) [PDF]

, 2013
The brown bear (Ursus arctos) hibernates for 5 to 6 months each winter and during this time ingests no food or water and remains anuric and inactive.
Abdul Rashid Qureshi, Johnson, Richard J,, Fröbert, Ole,, Peter Stenvinkel, Palm, Fredrik, Eriksson, Monica, Tobias Larsson, Zedrosser, Andreas, Josefsson, Johan, Johnson, Richard J., Anderstam, Björn, Friebe, Andrea,, Stenvinkel, Peter, Bankir, Lise, Johnson, Richard J, Sahdo, Berolla, Sahdo, Berolla,, Ann-Christin Bragfors-Helin, Andreas Zedrosser, Lise Bankir, Qureshi, Abdul Rashid,, Fröbert, Ole, Ole Fröbert, Björn Anderstam, Richard J Johnson, Anderstam, Björn,, Larsson, Tobias,, Friebe, Andrea, Berolla Sahdo, Bragfors-Helin, Ann-Christin,, Bragfors-Helin, Ann-Christin, Johnson, Richard J.,, Johan Josefsson, Josefsson, Johan,, Eriksson, Monica,, Qureshi, Abdul Rashid, Larsson, Tobias, Svensson, My, Stenvinkel, Peter,, Svensson, My,, My Svensson, Zedrosser, Andreas,, Palm, Fredrik,, Monica Eriksson, Bankir, Lise,, Fredrik Palm, Andrea Friebe, Zedrosser, A, Eriksson Monica, Larsson Tobias, Johnson Richard J., Josefsson Johan, Zedrosser Andreas, Anderstam Björn, Fröbert Ole, Frobert, O, Sahdo Berolla, Friebe Andrea, Qureshi Abdul Rashid, Bankir Lise, Stenvinkel Peter, Svensson My, Larsson, T,, Bragfors-Helin, A-C, Palm, F, Palm Fredrik, Eriksson, M,, Bragfors-Helin Ann-Christin, Friebe, A, Stenvinkel, P,, Anderstam, B,, Qureshi, AR   +71 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source