Results 261 to 270 of about 405,820 (287)

Novel amino acids: synthesis of furoxan and sydnonimine containing amino acids and peptides as potential nitric oxide releasing motifs

Organic & Biomolecular Chemistry, 2013
The incorporation of furoxan and sydnonimine ring systems into amino acid side chains is demonstrated with the preparation of four novel amino acids which carry these nitric oxide-releasing motifs. N-((4-Nitrophenoxy)carbonyl)-3-phenylsydnonimine 9 and bis(phenylsulfonyl)furoxan 10 are the key intermediates for introducing the heterocycle side chains ...
Andrew, Nortcliffe, Nigel P, Botting, David, O'Hagan   +2 more
openaire   +2 more sources

Searching for amino acid sequence motifs among enzymes: the Enzyme–Reaction Database

Bioinformatics, 1993
Recently we have constructed a database--the Enzyme-Reaction Database--which links a chemical structure to amino acid sequences of enzymes that recognize the chemical structure as their ligand. The total number of enzymes registered in the database is 1103 with 6668 NBRF-PIR entry codes and 1756 chemical compounds.
M, Suyama, A, Ogiwara, T, Nishioka, J, Oda   +3 more
openaire   +2 more sources

Web Server To Identify Similarity of Amino Acid Motifs to Compounds (SAAMCO)

Journal of Chemical Information and Modeling, 2008
Protein-protein interactions are fundamental in mediating biological processes including metabolism, cell growth, and signaling. To be able to selectively inhibit or induce protein activity or complex formation is a key feature in controlling disease.
Fergal P, Casey, Norman E, Davey, Ivan, Baran, Radka Svobodova, Varekova, Denis C, Shields   +4 more
openaire   +2 more sources

Chiral bis(amino acid)- and bis(amino alcohol)-oxalamidegelators. Gelation properties, self-assembly motifs and chirality effects

Chem. Commun., 2010
Bis(amino acid)- and bis(amino alcohol)oxalamide gelators represent the class of versatile gelators whose gelation ability is a consequence of strong and directional intermolecular hydrogen bonding provided by oxalamide units and lack of molecular symmetry due to the presence of two chiral centres.
Frkanec, Leo, Žinić, Mladen
openaire   +4 more sources

Synthesis and Screening of an Indexed Motif‐Library Containing Non‐proteinogenic Amino Acids

Journal of Peptide Science, 1997
In an effort to increase the probability of finding novel peptides in resin-bound combinatorial libraries displaying affinity to various macromolecular targets, we increased the diversity of a solid-phase library considerably by synthesizing multiple structures on each bead - a motif-library - including 45 building blocks.
Østergaard, S., Holm, A.
openaire   +2 more sources

Tailor‐Made Amino Acids and Fluorinated Motifs as Prominent Traits in Modern Pharmaceuticals

Chemistry – A European Journal, 2020
AbstractStructural analysis of modern pharmaceutical practices allows for the identification of two rapidly growing trends: the introduction of tailor‐made amino acids and the exploitation of fluorinated motifs. Curiously, the former represents one of the most ubiquitous classes of naturally occurring compounds, whereas the latter is the most ...
Haibo Mei, Jianlin Han, Sarah White, Daniel J. Graham, Kunisuke Izawa, Tatsunori Sato, Santos Fustero, Nicholas A. Meanwell, Vadim A. Soloshonok   +8 more
openaire   +2 more sources

Cellular localization of mitotic RAD21 with repetitive amino acid motifs in Allium cepa

Gene, 2013
Onion can be used in experimental observation of mitotic cell division in plant science because its chromosome is large and easy to observe. However, molecular genetic studies are difficult in onion because of its large genome size, and only limited information of onion genes has been available to date.
Go, Suzuki, Chikage, Nishiuchi, Asami, Tsuru, Eri, Kako, Jian, Li, Maki, Yamamoto, Yasuhiko, Mukai   +6 more
openaire   +2 more sources

Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs

Gene, 1994
The yeast TOR1 (DRR1) and TOR2 (DRR2) proteins are putative targets of the immunosuppressive drug rapamycin (Rm), defined by dominant drug-resistance mutations. They share a large C-terminal domain that exhibits sequence similarity to the 110-kDa subunit of phosphatidylinositol (PI) 3-kinases.
R, Cafferkey, M M, McLaughlin, P R, Young, R K, Johnson, G P, Livi   +4 more
openaire   +2 more sources

Regulation by Heme of Mitochondrial Protein Transport Through a Conserved Amino Acid Motif

Science, 1993
A conserved motif, termed the heme regulatory motif (HRM), was identified in the presequences of the erythroid δ-aminolevulinate synthase precursors and was shown to be involved in hemin inhibition of transport of these proteins into mouse mitochondria in vitro. When the HRM was inserted into the presequence of the ornithine transcarbamoylase precursor,
J T, Lathrop, M P, Timko
openaire   +2 more sources

Motifs and conformational analysis of amino acid residues adjoining β‐turns in proteins

International Journal of Peptide and Protein Research, 1996
Using a data set of 250 non‐homologous high‐resolution globular proteins, a systematic analysis of the conformations that precede and succeed (positions i and i+3) the various classical β‐turn types has been carried out. The collective conformation of a specific β‐turn type, including the flanking positions, termed motif, has been studied.
Ramakrishnan, C, Srinivasan, N, Nataraj, DV   +2 more
openaire   +2 more sources