Results 121 to 130 of about 2,474,551 (357)

Cloning and Expression Analysis of Clock Genes During Ovarian Development and Maturation of Tongue Sole (Cynoglossus semilaevis)

Progress in Fishery Sciences
Clock genes play a pivotal role in the rhythm maturation of bony fish ovaries. To explore the role of clock genes in the rhythmic ovarian development and maturation of tongue sole (Cynoglossus semilaevis), we used real-time fluorescent quantitative PCR ...
Kewen YAN, Xiaodong MA, Bao SHI, Hanliang CHENG, Chongnü WANG, Xinyu ZHAO   +5 more
doaj   +1 more source

Multiple sequence alignments of partially coding nucleic acid sequences

BMC Bioinformatics, 2005
Background High quality sequence alignments of RNA and DNA sequences are an important prerequisite for the comparative analysis of genomic sequence data.
Fried Claudia, Hofacker Ivo L, Stocsits Roman R, Stadler Peter F   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Synthesis of a cyclen-functionalized alpha-amino acid and its incorporation into peptide sequence

, 2005
A cyclen-functionlized alpha-amino acid was obtained through embedding cyclen into the side chain of homoserine. The a-amino acid can be conveniently incorporated into peptide sequence to form new ligands, which have strong coordination ability for ...
Yu, XQ, Sichuan Univ, Dept Chem, Key LGreen Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China., Yu, H, Cheng, H, Ma, LJ, Huang, Y, Chen, SY, Yu, XQ, Xia, CQ, Zhang, GL   +8 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

M-ES amino acid sequence.

, 2014
M-ES amino acid sequence.
Lvzhen Huang (128928), Shanshan Li (114847), Yujing Bai (170144), Min Zhao (66793), Chunfang Zhang (7405), Xiaoxin Li (128947), Yun Qi (560401), Bin Wang (30851)   +7 more
core   +1 more source

Accurate prediction of substitution rates at protein sites with a mutation-selection model

Scientific Reports
The pattern of substitutions at sites in proteins provides invaluable information about their biophysical and functional importance and what selection pressures are acting at individual sites.
Ingemar André
doaj   +1 more source

Identification of Short Amino Acid Sequences That Correlate with Cytoplasmic Retention of Human Proteins

Cells
One group of human proteins found in the cytoplasm, but not in the nucleus, is characterized by the presence of short (6–9 aa), specific amino acid sequences thought to be involved in retaining proteins in the cytoplasm (cytoplasmic retention sequences).
Jay C. Brown, Baomin Wang
doaj   +1 more source

Partial molecular characterization of the Nile tilapia (Oreochromis niloticus) alpha-cardiac muscle actin gene and its relationship to actin isoforms of other fish species

Genetics and Molecular Biology, 2007
An alpha actin gene segment, isolated from Nile tilapia (Oreochromis niloticus), was characterized by nucleotide sequencing, predicted amino acid sequence and Southern blot hybridization.
Adriane P. Wasko, Fábio E. Severino, Flávia T. Presti, Andréia B. Poletto, Cesar Martins   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source