Results 21 to 30 of about 75 (74)

Cloning and functional expression of a cDNA from rat jejunal epithelium encoding a protein (4F2hc) with system y+L amino acid transport activity [PDF]

Biochemical Journal, 1998
Two different protein families, designated CAT (cationic amino acid transporter) and BAT (broad-specificity amino acid transporter) mediate the plasma membrane transport of cationic amino acids in animal cells. CAT transporters have 12-14 transmembrane domains and are selective for cationic amino acids.
S Y, Yao, W R, Muzyka, J F, Elliott, C I, Cheeseman, J D, Young   +4 more
openaire   +2 more sources

The Binding Specificity of Amino Acid Transport System y + L in Human Erythrocytes is Altered by Monovalent Cations

Journal of Membrane Biology, 1996
System y+L is a broad-scope amino acid transporter which binds and translocates cationic and neutral amino acids. Na+ replacement with K+ does not affect lysine transport, but markedly decreases the affinity of the transporter for L-leucine and L-glutamine.
Angelo,, Irarrázabal,, Devés, Rosa
openaire   +3 more sources

Inhibition of endothelial cell amino acid transport System y+ by arginine analogs that inhibit nitric oxide synthase

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1997
A variety of N omega-monosubstituted L-arginine analogs are established inhibitors of nitric oxide synthase; in all cases, initial binding is competitive with the substrate L-arginine. The efficacy of such compounds in vivo will depend on their transport into the relevant nitric oxide synthase-containing cells; in fact, inhibition may actually be ...
McDonald, Kelly K, Rouhani, Riaz, Handlogten, Mary E, Block, Edward R, Griffith, Owen W, Allison, R.Donald, Kilberg, Michael S   +6 more
openaire   +2 more sources

Characterization of blood-brain barrier L-arginine uptake using in situ brain perfusions in a female mouse model

Fluids and Barriers of the CNS
Background L-arginine is a critical determinant of central nervous system (CNS) function through nitric oxide (NO) production. Its uptake from plasma into brain is dependent on carrier-mediated transport across the blood-brain barrier (BBB).
Olivia C. Milam, Cullen P. Wolford, Geoffrey L. Pecar, Joshua J. Applegate, Maxine E. Casto, Dominic J. Gabriele, Austin S. Nestor, Paul R. Lockman   +7 more
doaj   +1 more source

Intrauterine Growth Retardation Is Associated With Reduced Activity and Expression of the Cationic Amino Acid Transport Systems y ⁺ /hCAT-1 and y ⁺ /hCAT-2B and Lower Activity of Nitric Oxide Synthase in Human Umbilical Vein Endothelial Cells [PDF]

Circulation Research, 2002
Intrauterine growth retardation (IUGR) is associated with vascular complications leading to hypoxia and abnormal fetal development. The effect of IUGR on l -arginine transport and nitric oxide (NO) synthesis was investigated in cultures of human umbilical vein endothelial cells (HUVECs).
Paola Casanello, Luis Sobrevia
openaire   +1 more source

Saturation kinetics and specificity of transporters for L-arginine and asymmetric dimethylarginine (ADMA) at the blood-brain and blood-CSF barriers.

PLoS ONE
Nitric oxide synthases (NOS) synthesize nitric oxide (NO) from L-arginine in endothelial and neuronal cells. Asymmetric dimethylarginine (ADMA) is a homologue of arginine and an endogenous inhibitor of NOS.
Mehmet Fidanboylu, Sarah Ann Thomas
doaj   +1 more source

Nitric Oxide Synthesis Requires Activity of the Cationic and Neutral Amino Acid Transport System y⁺L in Human Umbilical vein Endothelium

Experimental Physiology, 2003
L‐Arginine transport is mediated by the cationic/neutral amino acid transport system y+L and cationic amino acid transporters y+/CATs in human umbilical vein endothelial cells (HUVECs). System y+/CATs activity may be rate‐limiting for nitric oxide (NO) synthesis, but no reports have demonstrated system y+L involvement in NO synthesis in endothelium. We
Arancibia Garavilla, Y, Toledo, F, Casanello, P, Sobrevia, L   +3 more
openaire   +5 more sources

Molecular Characterization and Expression Response Under Hypoxic-Reoxygenation Stress of a Crustacyanin-Like Gene in Procambarus clarkii

Progress in Fishery Sciences
Crustacyanin (CRCN), a family of lipocalin proteins specific to crustaceans, was primarily found in the exoskeleton of crustaceans. By binding with astaxanthin to form the astaxanthin-binding protein complex, it resets the proton at the end of ...
Yiming HAN, Suwan LU, Zhiqiang XU, Yu XU, Hai LIN, Jianlin PAN, Jiaxin YANG, Xuguang LI   +7 more
doaj   +1 more source

Both the H13 gene product and 4F2 antigen are involved in the induction of system y+ cationic amino-acid transport following activation of human peripheral blood mononuclear cells (PBM)

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1996
Prior transfection with antisense oligonucleotides to the H13 and 4F2 hc genes, singly or in combination, was found to inhibit phytohaemagglutinin-induced activation of cationic amino-acid transport system y+ in human peripheral blood mononuclear cells (mostly circulating lymphocytes).
Chen, S, Meredith, D, Boyd, C
openaire   +3 more sources

Metabolismo celular de la glucosa y la amoniogénesis en el riñón Glucose cellular metabolism and ammoniagenesis in the kidney

Revista Habanera de Ciencias Médicas, 2012
Introducción: al igual que el hígado, el riñón realiza actividades metabólicas complejas, esto es posible debido a la presencia de múltiples complejos enzimáticos capaces de realizar todas las transformaciones metabólicas necesarias. El metabolismo renal
Iecienia Espinosa Santisteban, Adina Pérez Mejías, Aydelín Pérez Ramos, María Ofelia Barber Fox   +3 more
doaj