Results 31 to 40 of about 43,145,716 (262)
N-System Amino Acid Transport at the Blood-CSF Barrier [PDF]
, 1995 Despite l-glutamine being the most abundant amino acid in CSF, the mechanisms of its transport at the choroid plexus have not been fully elucidated. This study examines the role of L-, A-, ASC-, and N-system amino acid transporters in l-[ 14 C]glutamine ...
Xiang, Jianming +2 more
core +1 more source
The invertebrate transporters of SLC6 family are able to transport D-amino acid
, 2017 Neutral amino acids, which predominantly represent essential substrates in animals, are absorbed via a B0 transport system (the Broad neutral amino acid system).
E. Bossi +3 more
core +2 more sources
Journal of Biological Chemistry, 1990 The transport of [125I]triiodothyronine ([125I]T3) and [3H]tryptophan ([3H]Trp) by washed rat erythrocytes was studied at 25 degrees C in the presence of leucine in order to block the neutral amino acid transport system L.
Y. Zhou +4 more
semanticscholar +1 more source
The regulation of neutral amino acid transport by amino acid availability in animal cells [PDF]
, 1983 Animal cells regulate the activities of neutral amino acid transport Systems A and L to keep the intracellular supply of amino acids relatively constant. Transport System A activity increases dramatically in response to starvation of all the amino acids.
Shotwell, Mark A., Oxender, Dale L.
core +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Characteristics of the Amino Acid Transport System in the Mucosal Border of Rabbit Ileum
The Journal of General Physiology, 1970 The specificity of the neutral amino acid transport system in the brush border was examined by studying the ability of amino acid analogues to inhibit the unidirectional influx of phenylalanine from mucosal solution into the cells. Effects were evaluated
J. Hajjar, P. Curran
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Effect of oxygen tension on the amino acid utilisation of human embryonic stem cells
, 2014 Background/aims: human embryonic stem cells (hESCs) are a potential source of cells for treatment of many degenerative diseases, but in culture have a propensity to spontaneously differentiate, possibly due to suboptimal conditions. Culture at low oxygen
Christensen, David R. +5 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source