Results 21 to 30 of about 240,261 (222)

System y+L: the broad scope and cation modulated amino acid transporter

Experimental Physiology, 1998
The properties are discussed of system y+L, a broad scope amino acid transporter which was first identified in human erythrocytes. System y+L exhibits two distinctive properties: (a) it can bind and translocate cationic and neutral amino acids, and (b) its specificity varies depending on the ionic composition of the medium.
R, Devés, S, Angelo, A M, Rojas
openaire   +2 more sources

The amino acid transport system y ⁺ L/4F2hc is a heteromultimeric complex

The FASEB Journal, 1998
4F2hc is an almost ubiquitous transmembrane protein in mammalian cells; upon expression in Xenopus laevis oocytes, it induces amino acid transport with characteristics of system y + L.
Estévez, Raúl, Camps, Marta, Rojas, Ana María, Testar, Xavier, Devés, Rosa, Hediger, Matthias A., Zorzano, Antonio, Palacín, Manuel   +7 more
openaire   +2 more sources

Function of SLC7A7 in T-Cell Acute Lymphoblastic Leukemia

Cellular Physiology and Biochemistry, 2018
Background/Aims: Y+LAT1 protein, encoded by the SLC7A7 gene (a member of the SLC7 family), forms the cationic amino acid transport system y+L (system y+L). This system transports cationic amino acids such as arginine and lysine out of the cell. Arginine,
Xiaohui Ji, Xiaoyun Yang, Nan Wang, Meiyun Kang, Yaping Wang, Liucheng Rong, Yongjun Fang, Yao Xue   +7 more
doaj   +1 more source

Analysis of LPI-causing mutations on y+LAT1 function and localization

Orphanet Journal of Rare Diseases, 2019
Background y+LAT1, encoded by SCL7A7, is the protein mutated in Lysinuric Protein Intolerance (LPI), a rare metabolic disease caused by a defective cationic amino acid (CAA, arginine, lysine, ornithine) transport at the basolateral membrane of intestinal
Bianca Maria Rotoli, Amelia Barilli, Filippo Ingoglia, Rossana Visigalli, Massimiliano G. Bianchi, Francesca Ferrari, Diego Martinelli, Carlo Dionisi-Vici, Valeria Dall’Asta   +8 more
doaj   +1 more source

Stimulation of system y(+)-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes. [PDF]

Proceedings of the National Academy of Sciences, 1992
A kidney cortex cDNA clone (rBAT) has recently been isolated, which upon in vitro transcription and capping complementary RNA (cRNA) and injection into Xenopus laevis oocytes induces a system b0,(+)-like amino acid transport activity. This cDNA encodes a type II membrane glycoprotein that shows significant homology to another type II membrane ...
Bertran, J, Magagnin, S, Werner, A, Markovich, D, Biber, J, Testar, X, Zorzano, A, Kuhn, LC, Palacin, M, Murer, H   +9 more
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Uptake of Manganese from the Manganese-Lysine Complex in Primary Chicken Intestinal Epithelial Cells

Animals, 2019
Organic manganese (Mn) sources can replace inorganic Mn as dietary Mn supplements in poultry. To compare the uptake of Mn from the Mn-lysine complex (MnLys) and MnSO4, we first established the primary chicken intestinal epithelial cells (IECs) model and ...
Shiping Bai, Keying Zhang, Xuemei Ding, Jianping Wang, Qiufeng Zeng, Huanwei Peng, Jie Bai, Yue Xuan, Zuowei Su, Bin Wu   +9 more
doaj   +1 more source

Angiotensin II Stimulates System y+ and Cationic Amino Acid Transporter Gene Expression in Cultured Vascular Smooth Muscle Cells [PDF]

Journal of Biological Chemistry, 1995
The effect of angiotensin II (Ang II) on the transport of cationic amino acids has been examined in vascular smooth muscle cells (VSMC) isolated from rat aortae. Ang II stimulated the uptake rates of radiolabeled arginine and lysine in a time- and concentration-dependent manner.
B C, Low, M R, Grigor
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Downregulation of SLC7A7 Triggers an Inflammatory Phenotype in Human Macrophages and Airway Epithelial Cells

Frontiers in Immunology, 2018
Lysinuric protein intolerance (LPI) is a recessively inherited aminoaciduria caused by mutations of SLC7A7, the gene encoding y+LAT1 light chain of system y+L for cationic amino acid transport. The pathogenesis of LPI is still unknown.
Bianca Maria Rotoli, Amelia Barilli, Rossana Visigalli, Filippo Ingoglia, Marco Milioli, Maria Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall’Asta   +8 more
doaj   +1 more source

Important differences in cationic amino acid transport by lysosomal system c and system y+ of the human fibroblast.

Journal of Biological Chemistry, 1987
Superficial similarities led us to extend our designation for the transport of the plasma membrane for cationic amino acids, y+, to the lysosomal system also serving for such amino acids. Further study on the purified lysosomes of human skin fibroblasts leads us now to redesignate the lysosomal system as c (for cationic), rather than y+, to emphasize ...
R L, Pisoni, J G, Thoene, R M, Lemons, H N, Christensen   +3 more
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Obligatory amino acid exchange via systems bo,+-like and y+L-like. A tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino acids.

The Journal of biological chemistry, 1996
Mutations in the rBAT gene cause type I cystinuria, a common inherited aminoaciduria of cystine and dibasic amino acids due to their defective renal and intestinal reabsorption (Calonge, M. J., Gasparini, P., Chillarón, J., Chillón, M., Gallucci, M., Rousaud, F., Zelante, L., Testar, X., Dallapiccola, B., Di Silverio, F., Barceló, P., Estivill, X ...
J, Chillarón, R, Estévez, C, Mora, C A, Wagner, H, Suessbrich, F, Lang, J L, Gelpí, X, Testar, A E, Busch, A, Zorzano, M, Palacín   +10 more
openaire   +3 more sources