JMIR Research Protocols, 2023 BackgroundFatigue is a strong predictor of negative health outcomes in older adults. Kynurenine, a metabolite of tryptophan, is strongly associated with fatigue.
Ronna N Robbins +4 more
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SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer
Cancer Cell International, 2021 Background SLC7A7 (solute carrier family 7, amino acid transporter light chain, y + L system, member 7) is a critical gene in the regulation of cationic amino acid transport.
Wumin Dai +7 more
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Transport of Amino Acids Across the Blood-Brain Barrier
Frontiers in Physiology, 2020 The blood-brain-barrier (BBB), present in brain capillaries, constitutes an essential barrier mechanism for normal functioning and development of the brain.
Rosa Zaragozá
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System y+L: the broad scope and cation modulated amino acid transporter
Experimental Physiology, 1998 The properties are discussed of system y+L, a broad scope amino acid transporter which was first identified in human erythrocytes. System y+L exhibits two distinctive properties: (a) it can bind and translocate cationic and neutral amino acids, and (b) its specificity varies depending on the ionic composition of the medium.
R, Devés, S, Angelo, A M, Rojas
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Function of SLC7A7 in T-Cell Acute Lymphoblastic Leukemia
Cellular Physiology and Biochemistry, 2018 Background/Aims: Y+LAT1 protein, encoded by the SLC7A7 gene (a member of the SLC7 family), forms the cationic amino acid transport system y+L (system y+L). This system transports cationic amino acids such as arginine and lysine out of the cell. Arginine,
Xiaohui Ji +7 more
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The amino acid transport system y + L/4F2hc is a heteromultimeric complex
The FASEB Journal, 1998 4F2hc is an almost ubiquitous transmembrane protein in mammalian cells; upon expression in Xenopus laevis oocytes, it induces amino acid transport with characteristics of system y + L.
Estévez, Raúl +7 more
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Analysis of LPI-causing mutations on y+LAT1 function and localization
Orphanet Journal of Rare Diseases, 2019 Background y+LAT1, encoded by SCL7A7, is the protein mutated in Lysinuric Protein Intolerance (LPI), a rare metabolic disease caused by a defective cationic amino acid (CAA, arginine, lysine, ornithine) transport at the basolateral membrane of intestinal
Bianca Maria Rotoli +8 more
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Stimulation of system y(+)-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes. [PDF]
Proceedings of the National Academy of Sciences, 1992 A kidney cortex cDNA clone (rBAT) has recently been isolated, which upon in vitro transcription and capping complementary RNA (cRNA) and injection into Xenopus laevis oocytes induces a system b0,(+)-like amino acid transport activity. This cDNA encodes a type II membrane glycoprotein that shows significant homology to another type II membrane ...
Bertran, J +9 more
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Uptake of Manganese from the Manganese-Lysine Complex in Primary Chicken Intestinal Epithelial Cells
Animals, 2019 Organic manganese (Mn) sources can replace inorganic Mn as dietary Mn supplements in poultry. To compare the uptake of Mn from the Mn-lysine complex (MnLys) and MnSO4, we first established the primary chicken intestinal epithelial cells (IECs) model and ...
Shiping Bai +9 more
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Angiotensin II Stimulates System y+ and Cationic Amino Acid Transporter Gene Expression in Cultured Vascular Smooth Muscle Cells [PDF]
Journal of Biological Chemistry, 1995 The effect of angiotensin II (Ang II) on the transport of cationic amino acids has been examined in vascular smooth muscle cells (VSMC) isolated from rat aortae. Ang II stimulated the uptake rates of radiolabeled arginine and lysine in a time- and concentration-dependent manner.
B C, Low, M R, Grigor
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