Results 61 to 70 of about 212,752 (309)
Amino AcidsAmong the 20 standard amino acids, aromatic amino acids hold particular importance due to their crucial roles in protein–protein interactions. These residues, including phenylalanine, tyrosine, tryptophan, and histidine, contribute significantly to ...
Sepideh Kalhor, Alireza Fattahi
doaj +1 more source
Stochastic Analysis of Aromatic Amino Acids Chromatographic Pulses
Chemical Engineering Transactions, 2017 The amino acids L-phenylalanine (Phe), L-tyrosine (Tyr) and L-Tryptophan (Trp) play an important role in the human body. L-Phenylalanine and L-tyrosine are precursors of several neurotransmitters, while Trp has been indicated as an aid for schizophrenic ...
M. Cremasco +4 more
doaj +1 more source
Amino acid uptake in Arabidopsis [PDF]
, 2008 Nitrogen (N) is essential for all living organisms and is considered to be the limiting factor for plant growth in many ecosystems. Although generally believed to rely on mineral N to fulfill their N needs, plants have also been found to access organic N
Svennerstam, Henrik
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
High Order Structures Formed by the Natural Aromatic Amino Acids
, 2023 Excessive concentrations of the natural aromatic amino acids phenylalanine and tyrosine are characteristic of the severe genetic abnormalities known as phenylketonuria (PKU) and tyrosinemia, respectively.
Kupovics, Gabriel Alexander +1 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Suzuki-Miyaura diversification of amino acids and dipeptides in aqueous media
, 2015 The authors gratefully acknowledge the IWT Flanders and Janssen Pharmaceutica for financial support of T.W. This work is supported by the Scientific Research Network (WOG) “Sustainable chemistry for the synthesis of fine chemicals” of the Research ...
Van Imp, Karolien +17 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Frontiers in Physiology, 2017 Amino acids applied to the mucosa evoke inhibitory reflexes in guinea-pig jejunum, but the receptors involved in sensory transduction are still unclear.
Rachel M. Gwynne +3 more
doaj +1 more source