Results 131 to 140 of about 2,480,811 (338)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique

Amino Acids
Biomarkers that accurately reflect renal function are essential in management of chronic kidney diseases (CKD). However, in children, age/physique and medication often alter established renal biomarkers.
Toshimasa Morishita, Naoto Nishizaki, Sakiko Taniguchi, Shinsuke Sakai, Tomonori Kimura, Masashi Mita, Mayu Nakagawa, Amane Endo, Yoshiyuki Ohtomo, Masato Yasui, Toshiaki Shimizu, Jumpei Sasabe   +11 more
doaj   +1 more source

Amino acids precursors in lunar finds [PDF]

The consistent pattern is discussed of amino acids found in lunar dust from Apollo missions. The evidence indicates that compounds yielding amino acids were implanted into the surface of the moon by the solar wind, and the kind and amounts of amino acids
Fox, S. W., Harada, K., Hare, P. E., Hinsch, G., Mueller, G.   +4 more
core   +1 more source

Early Life Relict Feature in Peptide Mass Distribution [PDF]

, 2008
Molecular mass of a biomolecule is characterized in mass spectroscopy by the monoisitopic mass M~mono~ and the average isotopic mass M~av~. We found that peptide masses mapped on a plane made by two parameters derived from M~mono~ and M~av~ form a ...
Alexander R. Zubarev, Corina Mayrhofer, Eva Y. M. Fung, Konstantin Artemenko, Roman A. Zubarev   +4 more
core   +1 more source

Inner Amino Acid Contacts Are Key Factors of Multistage Structural Rearrangements of DNA and Affect Substrate Specificity of Apurinic/Apyrimidinic Endonuclease APE1 [PDF]

, 2023
Anatoly A. Bulygin, Victoria N. Syryamina, А. А. Кузнецова, Д. С. Новопашина, Sergei A. Dzuba, Nikita A. Kuznetsov   +5 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Impact of smokeless tobacco on psychological and oxidative stress in unemployed indian youth

Amino Acids
In India, tobacco (nicotine) addiction among youth has increased, leading to substantial socioeconomic burdens, mortality, and morbidity. While minimal short-term nicotine consumption may have antioxidant effects, chronic exposure results in various ...
Anurag Mishra, Rishabh Kumar, Satya Narayan Mishra, Sivakumar Vijayaraghavalu, Girish C. Shukla, Munish Kumar   +5 more
doaj   +1 more source

Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.

, 1988
Cheng-Shyong Chang, John M. Kokontis, Shutsung Liao   +2 more
openalex   +2 more sources

Amino Acid Residues in the αIIb Subunit That Are Critical for Ligand Binding to Integrin αIIbβ3 Are Clustered in the β-Propeller Model [PDF]

, 2001
Tetsuji Kamata, Kenneth Khiem Tieu, Atsushi Irie, Timothy A. Springer, Yoshikazu Takada   +4 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source