Results 131 to 140 of about 1,482,447 (317)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Regulatory effects of blood constituents on the function and metabolism of the cat brain in perfusion ezperiments. Brain perfusion with artificial blood containing low molecular dextran and amino acids

, 1967
As a link in a series of studies on the effects of blood constituents on the brain function by means of brain perfusion, we used four kinds of artificial blood; namely, the blood containing a low molecular dextran, one containing glutamic acid, one ...
Nakashima, Yoshihiko, Watanabe, Shosuke, Okumura, Nikichi, Edamatsu, Kazuyasu, Otsuki, Saburo, Morimitsu, Junsuke   +5 more
core   +1 more source

Adaptive crosstalk between polyamine metabolism, translation, and autophagy sustains energy homeostasis in mammals during starvation: a scoping review

Amino Acids
Mammalian cells tightly regulate the shift between catabolism and anabolism to maintain energy homeostasis during starvation. Among other adaptations, cells adapt to nutrient restriction by downregulating translation, the most energy consuming cellular ...
Kayhan Karimi, Sigrid C. Roberts, Nicola S. Carter, Sebastian J. Hofer, Reza Karimi   +4 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Olfactory sensitivity for six amino acids: a comparative study in CD-1 mice and spider monkeys

, 2011
Using a conditioning paradigm, the olfactorysensitivity of five CD-1 mice for the L- and D-forms ofcysteine, methionine, and proline was investigated.
Hernandez Salazar, Laura Teresa,, Matthias Laska, Helena Wallén, Laska, Matthias,, Ida Engström, Engström, Ida,, Wallén, Helena,, Laura Teresa Hernandez Salazar   +7 more
core   +1 more source

Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders

Amino Acids
Neurodegenerative disorders are an Critical worldwide issue, characterized by progressive neuronal loss and cognitive decline with limited effective therapies.
Tushar Adhikari, Prerona Saha
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Comparative effects of acute-methionine loading on the plasma sulfur-amino acids in NAC-supplemented HIV+ patients and healthy controls

, 2018
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Processo FAPESP: 99/01716-0In this study, an acute overloading of methionine (MetLo) was used to investigate the trassulfuration pathway response comparing healthy controls and HIV+ patients ...
Burini, Roberto Carlos, Fernando Moreto, Yu, Yong- Ming, Borges-Santos, Maria Doroteia, Yong- Ming Yu, Moreto, Fernando [UNESP], Borges-Santos, Maria Doroteia [UNESP], Roberto Carlos Burini, Moreto, Fernando, Burini, Roberto Carlos [UNESP], Maria Doroteia Borges-Santos   +10 more
core   +1 more source

A systematic review and meta-analysis of clinical trials on the effects of glutamine supplementation on gut permeability in adults

Amino Acids
The gastrointestinal tract's epithelial barrier plays a crucial role in maintaining health. This study aims to investigate the impact of glutamine supplementation on intestinal permeability, considering its importance for immune function and nutrient ...
Fatemeh Abbasi, Mohammad Mehdi Haghighat Lari, Gholamreza Reza Khosravi, Elahe Mansouri, Nastaran Payandeh, Alireza Milajerdi   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source