Results 161 to 170 of about 2,550,027 (311)

Amino acids industry knowledge service platform

, 2015
<b>Purpose</b>: This paper introduces an amino acids industry knowledge service platform, which integrates industry data, science literature, and technology knowledge from patents. <br><br><b>Design/methodology/approach<
Shu FANG, WEN Yi, Xian ZHANG, Qinggang LI, Zhengyin HU, Yuexian ZHU, Chunjiang LIU, FU Hongguang, Ning YANG, Yuan XU, Chenjun Ding, Yi WEN (E-mail: weny@clas.ac.cn)   +11 more
core  

Nucleobase Amino Acids in the Development of Amide-Linked Oligonucleotide Mimics. [PDF]

ChemMedChem
Baruah E, Chakraborty TK.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Modular synthesis of α-tertiary amino acids from C-H feedstocks. [PDF]

Chem Sci
Xu M, Yang E, Dong VM.
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Squaramide-functionalised amino acids and their application in solid-phase peptide synthesis. [PDF]

RSC Adv
Agnew-Francis KA, Chen RM, Robertson AAB.   +2 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Similarity-Enhanced Representation Learning of Non-Canonical Amino Acids for Therapeutic Peptide Modeling. [PDF]

Adv Sci (Weinh)
Xu C, Wei L, Wang J, Xiong Y, Zhang R, Wang Y, Zha C, Zeng Q, Gao X.   +8 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Oxidative stress in pigs and opportunities with selenium-containing amino acids. [PDF]

Stress Biol
Kim SW, de Oliveira Telesca Camargo N, Merdy O, Kiros T, Zhao Y.   +4 more
europepmc   +1 more source