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Process Safety Assessment of the Iron-Catalyzed 1,2-<i>cis</i>-Selective Glycal Aminoglycosylation. [PDF]
Org Process Res DevZhang D +5 more
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Global epidemiology of carbapenem-resistant <i>Pseudomonas aeruginosa</i>. [PDF]
JAC Antimicrob ResistGottesdiener LS, Satlin MJ.
europepmc +1 more source
Pharmacokinetics of Aminoglycosides in the Newborn
Current Pharmaceutical Design, 2012 Aminoglycosides have played a major role in antimicrobial therapy since their discovery in the 1940s. Their bactericidal efficacy in gram-negative infections, synergism with beta-lactam antibiotics, limited bacterial resistance, and low cost have given these agents a firm place in antimicrobial treatment. After penicillins, aminoglycosides are the most
van den Anker, Johannes N. +1 more
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Medical Clinics of North America, 1995
Despite their nephrotoxic and ototoxic side effects, AG remain useful antibiotics because of their major, rapid, and dose-dependent bactericidal effects. Combination therapy with an AG appears particularly important in neutropenic and other high-risk patients to provide broad-spectrum bactericidal activity, synergism, and reduction of emergence of ...
O, Lortholary +3 more
openaire +2 more sources
Despite their nephrotoxic and ototoxic side effects, AG remain useful antibiotics because of their major, rapid, and dose-dependent bactericidal effects. Combination therapy with an AG appears particularly important in neutropenic and other high-risk patients to provide broad-spectrum bactericidal activity, synergism, and reduction of emergence of ...
O, Lortholary +3 more
openaire +2 more sources
Clinical pharmacokinetics of aminoglycosides in the neonate: a review
European Journal of Clinical Pharmacology, 2008 Sepsis is common in neonates and is a major cause of morbidity and mortality. Sixty percent of preterm neonates receive at least one antibiotic, and 43% of the antibiotics administered to these neonates are aminoglycosides. The clearance (Cl), serum half-
Gian Maria Pacifici
exaly +2 more sources
Do we still need the aminoglycosides?
International Journal of Antimicrobial Agents, 2009 Since the introduction into clinical practice of the aminoglycoside class of antibiotics, a number of other antimicrobial agents with improved safety pro. le have entered the market.
Alexandros Grammatikos +2 more
exaly +2 more sources
Mayo Clinic Proceedings, 1991
Despite the introduction of newer, less toxic antimicrobial agents, the aminoglycosides continue to serve a useful role in the treatment of serious enterococcal, mycobacterial, and gram-negative bacillary infections. Gentamicin, because of its low cost, remains the aminoglycoside of choice in hospitals with low levels of resistance among ...
R S, Edson, C L, Terrell
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Despite the introduction of newer, less toxic antimicrobial agents, the aminoglycosides continue to serve a useful role in the treatment of serious enterococcal, mycobacterial, and gram-negative bacillary infections. Gentamicin, because of its low cost, remains the aminoglycoside of choice in hospitals with low levels of resistance among ...
R S, Edson, C L, Terrell
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Medical Clinics of North America, 1982
Aminoglycosides remain the cornerstone of prophylaxis and therapy against the majority of aerobic gram-negative organisms responsible for serious sepsis in the hospital. Gentamicin, tobramycin, amikacin are all equally efficacious against susceptible organisms and differ only in their patterns of resistance and pharmacokinetic profiles.
A M, Ristuccia, B A, Cunha
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Aminoglycosides remain the cornerstone of prophylaxis and therapy against the majority of aerobic gram-negative organisms responsible for serious sepsis in the hospital. Gentamicin, tobramycin, amikacin are all equally efficacious against susceptible organisms and differ only in their patterns of resistance and pharmacokinetic profiles.
A M, Ristuccia, B A, Cunha
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Resveratrol enhances the efficacy of aminoglycosides against Staphylococcus aureus
International Journal of Antimicrobial Agents, 2018 Development of new antibiotics is costly and time-consuming, and therefore increasing the efficacy of conventional antibiotics is extremely attractive.
Armen Ovsepian +2 more
exaly +2 more sources