Results 201 to 210 of about 13,598,018 (237)
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An aminopeptidase N deficiency in dog small intestine
Research in Veterinary Science, 1997This study has identified a naturally occurring, specific deficiency of a brush border aminopeptidase N (ApN) in the small intestines of five clinically healthy dogs. ApN activity in mucosal homogenates of dog small intestine was reduced significantly in deficient animals (13.4 (1.1) nmol min-1 mg-1 protein, n = 5, P < 0.002) compared to healthy ...
P W, Pemberton +3 more
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Enkephalin Metabolism by Microglia Aminopeptidase N (CD13)
Journal of Neurochemistry, 1995Abstract: Rat microglia in culture showed a high capacity to degrade neuropeptides compared with other glial cells. Leu‐enkephalin was readily hydrolyzed to free tyrosine and Gly‐Gly‐Phe‐Leu. Inhibition experiments and immunostaining revealed that aminopeptidase N (CD13) on the surface of microglia was responsible for enkephalin cleavage. Endopeptidase‐
R, Lucius, J, Sievers, R, Mentlein
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Human aortic endothelial cell aminopeptidase N
Immunopharmacology, 1996Aminopeptidase N (AmN) (EC 3.4.11.2) may function in part to degrade peptide hormones (Bausback and Ward, 1986; Kenny et al., 1989; Palmeiri et al., 1985; Ryan et al., 1993). AmN is capable of degrading angiotensin III, Lys-bradykinin, enkephalins and some enkephalin higher homologs (Bausback and Ward, 1986).
A, Papapetropoulos +6 more
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Discovery of Bioluminogenic Probes for Aminopeptidase N Imaging
Analytical Chemistry, 2014To find an approach that can image the hydrolysis activity of aminopeptidase N (APN) both in vitro and in vivo, three bioluminescent probes have been well designed and synthesized herein. All of them can be recognized and hydrolyzed by APN to produce bioluminescence emission in the presence of firefly luciferase.
Jing, Li +7 more
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Aminopeptidase N/CD13 and haematopoietic cells
Haema, 2003Several cell-surface antigens defined by the cluster of differentiation (CD) nomenclature have been defined as proteins with enzymatic activity. An important example is CD13, aminopeptidase N (APN ; EC 3.4.11.2). It is a zinc-dependent membrane-bound ectopeptidase that cleaves N-terminal neutral amino acids of various peptides.
Gabrilovac, Jelka +2 more
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Structure and Function of Aminopeptidase N
2002Sjøstrøm, Hans Gunnar +2 more
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Proteolytic Fragmentation of Aminopeptidase N
Biochemical Society Transactions, 1999Lisa D. Other, Nigel M. Hooper
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Targeting Methionine Aminopeptidase 2 in Cancer, Obesity, and Autoimmunity
Trends in Pharmacological Sciences, 2021Wouter W Kallemeijn +2 more
exaly
Aminopeptidase P in Individuals With a History of Angio-Oedema on ACE Inhibitors
Lancet, The, 2002Massimo Cugno +2 more
exaly