The Last Decade of Optically Active α-Aminophosphonates [PDF]
Molecules, 2023 α-Aminophosphonates and related compounds are important due to their real and potential biological activity. α-Aminophosphonates may be prepared by the Kabachnik–Fields condensation of oxo compounds, amines and dialkyl phosphites, or by the aza-Pudovik ...
Petra R. Varga, György Keglevich
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Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions [PDF]
Molecules, 2023 Several bis(α-aminophosphonates) have been conveniently prepared in good yields using a straightforward multicomponent Kabachnik–Fields reaction between ethane 1,2-diamine or propane 1,3-diamine, diethylphosphite and aldehydes under catalyst-free ...
Ichrak Souii +6 more
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Dipeptide analogues of fluorinated aminophosphonic acid sodium salts as moderate competitive inhibitors of cathepsin C [PDF]
Beilstein Journal of Organic Chemistry, 2023 In this paper, we present the solvolysis reaction of dipeptide analogues of fluorinated aminophosphonates with simultaneous quantitative deprotection of the amino group.
Karolina Wątroba +2 more
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Transdermal Delivery of α-Aminophosphonates as Semisolid Formulations—An In Vitro-Ex Vivo Study [PDF]
Pharmaceutics, 2023 α-Aminophosphonates are organophosphorus compounds with an obvious similarity with α-amino acids. Owing to their biological and pharmacological characteristics, they have attracted the attention of many medicinal chemists.
Dorottya Kocsis +9 more
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Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives [PDF]
Molecules, 2021 Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the ...
Aitor Maestro +5 more
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Access to 2-Fluorinated Aziridine-2-phosphonates from α,α-Halofluorinated β-Iminophosphonates—Spectroscopic and Theoretical Studies [PDF]
Molecules, 2023 The efficient one-pot halofluorination of a β-enaminophosphonate/β-iminophosphonate tautomeric mixture resulting in α,α-halofluorinated β-iminophosphonates is reported.
Mateusz Klarek +4 more
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Cytotoxic Activity of α-Aminophosphonic Derivatives Coming from the Tandem Kabachnik–Fields Reaction and Acylation [PDF]
Pharmaceuticals, 2023 Encouraged by the significant cytotoxic activity of simple α-aminophosphonates, a molecular library comprising phosphonoylmethyl- and phosphinoylmethyl-α-aminophosphonates, a tris derivative, and N-acylated species was established.
Petra R. Varga +4 more
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Practical and Efficient Synthesis of (E)-α,β-Unsaturated Amides Incorporating α-Aminophosphonates via the Horner–Wadsworth–Emmons Reaction [PDF]
MoleculesAn efficient and practical procedure for the synthesis of (E)-α,β-unsaturated amides incorporating α-aminophosphonates, derived from readily accessible phosphonoacetamides, via the Horner–Wadsworth–Emmons (HWE) reaction was developed.
Sindy Anahi Perez-Aniceto +4 more
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Asymmetric biomimetic transamination of α-keto phosphonates enabled by chiral pyridoxamines and synergistic solvent [PDF]
Nature CommunicationsChiral α-aminophosphonate derivatives are recognized as valuable compounds in both medicine and organic chemistry. Biomimetic transamination of α-keto phosphonates represents one of the most efficient strategies for accessing these pharmaceutically ...
Dongchen Cai +5 more
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Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates [PDF]
Pharmaceuticals, 2023 This review paper is focused on the design of anthracene and furan-containing Schiff bases and their advanced properties as ligands in complex transition metal ions The paper also provides a brief overview on a variety of biological applications, namely,
Ivelina Tsacheva +4 more
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