Phosphonate inhibitors of West Nile virus NS2B/NS3 protease
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 West Nile virus (WNV) is a member of the flavivirus genus belonging to the Flaviviridae family. The viral serine protease NS2B/NS3 has been considered an attractive target for the development of anti-WNV agents.
Marcin Skoreński +4 more
doaj +1 more source
Direct Synthesis of Phosphonates and α-Amino-phosphonates from 1,3-Benzoxazines
Molecules, 2019 A straightforward and novel method for transformation of readily available 1,3-benzoxazines to secondary phosphonates and α-aminophosphonates using boron trifluoride etherate as catalyst is developed.
Oscar Salgado-Escobar +3 more
doaj +1 more source
Supplementary data on rapid sample clean-up procedure of aminophosphonates for LC/MS analysis
MethodsX, 2020 Minimising matrix effects through high sample purity is of major importance for LC/MS analysis. Here we provide supplementary data and protocols related to the article “Rapid sample clean-up procedure of aminophosphonates for LC/MS analysis” (revised ...
Ramona Kuhn +2 more
doaj +1 more source
Angewandte Chemie, Volume 136, Issue 50, December 9, 2024.Direct Aminophosphonation: A new, metal‐free method has been developed to simultaneously aminate and phosphonylate imidazo[1,2‐a]pyridines using eco‐friendly solvents in normal air. This process is simple, sustainable, scalable, and functional‐group tolerant.
Silvia Roscales, Aurelio G. Csáky
wiley +2 more sources
Novel N-Arylaminophosphonates Bearing a Pyrrole Moiety and Their Ecotoxicological Properties
Molecules, 2017 A wide range of biological activities of aminophosphonates predisposes them to find applications as anticancer, antiviral, antimicrobial, antifungal, or herbicidal agents.
Jarosław Lewkowski +4 more
doaj +1 more source
Enzymatic and chromatographic resolution procedures applied to the synthesis of the phosphoproline enantiomers [PDF]
, 2015 Financial support to this work was provided by Ministerio de Economía y Competitividad–FEDER (grants CTQ2011-24237,CTQ2013-44153-P, and CTQ2013-40855 ...
Arizpe, Alicia +7 more
core +2 more sources
Cytotoxic effect and molecular docking of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide—a novel topoisomerase II inhibitor [PDF]
, 2012 The preliminary cytotoxic effect of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide hydrochloride (1)—a potent topoisomerase II inhibitor—was measured using a MTT assay.
Agata Siwek +5 more
core +1 more source
Acta Societatis Botanicorum Poloniae, 2014 The effect of new aminophosphonates, synthesized for potential agricultural application, on membrane potential and electrical conductance of internodal cells of Nitellopsis obtusa and their efficiency in modifying the properties of cucumber (Cucumis ...
Janusz Sarapuk +2 more
doaj +1 more source
Deep Eutectic Solvents: The Organic Reaction Medium of the Century [PDF]
, 2016 This microreview summarizes the use of deep eutectic solvents (DESs) and related melts in organic synthesis. Solvents of this type combine the great advantages of other proposed environmentally benign alternative solvents, such as low toxicity, high ...
Abbott +192 more
core +2 more sources
Microwave-assisted synthesis of α-aminophosphonates with sterically demanding α-aryl substituents [PDF]
, 2020 A series of N-benzhydryl protected α-aminophosphonates with α-phenyl, α-(1-naphtyl), α-(9-anthryl) or α-(1-pyrenyl) substituents was synthesized by the Kabachnik–Fields condensation of diphenylmethylamine (benzhydrylamine), the corresponding aryl ...
Bálint, Erika +5 more
core +1 more source