Results 71 to 80 of about 2,267 (195)
Efficient synthesis of dipeptide analogues of α-fluorinated β-aminophosphonates
Beilstein Journal of Organic Chemistry, 2020 Herein, we present an efficient synthesis of dipeptide analogues of α-fluorinated β-aminophosphonates. Each step of the synthesis was optimized to provide excellent yields.
Marcin Kaźmierczak, Henryk Koroniak
doaj +1 more source
Addition and cycloaddition reactions of Phosphinyl- and Phosphonyl-2H-Azirines, Nitrosoalkenes and Azoalkenes [PDF]
, 2012 An overview of the use of 2H-azirines, conjugated nitrosoalkenes and conjugated azoalkenes bearing phosphorus substituents in addition and cycloaddition reactions is presented, focused on strategies for the synthesis of aminophosphonate and ...
Lemos, A.
core
Stereoselective Synthesis of α‐Aminophosphonic Acids through Pudovik and Kabachnik‐Fields Reaction [PDF]
, 2017 Representative examples concerning the Pudovik and Kabachnik‐Fields reactions as the main strategies for the stereoselective synthesis of α‐aminophosphonic acids are discussed, classifying these reactions according to the chiral auxiliary and chiral ...
Ordóñez, Mario +2 more
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Chemistry &Biodiversity, Volume 21, Issue 12, December 2024.Abstract HIV‐1 remains a major health problem worldwide since the virus has developed drug‐resistant strains, so, the need for novel agents is urgent. The protein reverse transcriptase plays fundamental role in the viruses’ replication cycle. FDA approved Delavirdine bearing a sulfonamide moiety, while thiazolidinone has demonstrated significant anti ...
Maria Fesatidou +2 more
wiley +1 more source
Synthesis and Bioactivity of a-Aminophosphonates Containing Fluorine
Molecules, 2003 Twenty-one a-aminophosphonates containing fluorine were synthesized by Mannich-type reactions. Their structures were established by elemental analysis, IR, 1H- NMR and MS.
Lin-Hong Jin +5 more
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ChemMedChem, Volume 19, Issue 21, November 4, 2024.Phosphonates represent unique chemical space among the biologically active compounds. Several compounds were measured on various human cancer cell lines and many of them showed remarkable cytotoxic activities. To assess their potential protein targets the structure of the hits were compared with known agents annotated with targets using fingerprint ...
György Dormán +2 more
wiley +1 more source
Badania stereochemii addycji H-fosfonianów do chiralnych i achiralnych diimin [PDF]
, 2015 Celem pracy doktorskiej było zbadanie stereochemii reakcji addycji H-fosfonianów do wybranych diimin. Praca w szczególności skupiała się na stereoselektywnej addycji do imin opartych na szkielecie (R,R)-1,2-diaminocykloheksanu.
Tokarz, Paweł
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Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3 [PDF]
, 2015 BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts through a family of five G-protein-coupled receptors (S1PR1-5) and plays a key role in regulating the inflammatory response.
Guerrero, Miguel +4 more
core +1 more source
Advanced Synthesis &Catalysis, Volume 366, Issue 19, Page 3926-3942, October 8, 2024.Abstract Chiral N‐heterocyclic compounds are key structures in natural compounds and pharmaceuticals, and they serve as essential building blocks of functional materials. Catalytic asymmetric cycloaddition reactions represent one of the most efficient synthetic strategies for constructing optically active heterocycles.
Jong‐Un Park, Ju Hyun Kim
wiley +1 more source
Green Metrics and Sustainability in Photocatalysis
ChemCatChem, Volume 16, Issue 14, July 22, 2024.Lights and shadows in photocatalysis. This Review analyzes the sustainability of photoredox catalytic processes in the context of mass‐based metrics, highlighting significant sustainability issues in photocatalysts synthesis and in catalytic protocols, primarily driven by energy demanding preparations and by solvent intensive work‐up and purification ...
Arianna Quintavalla +2 more
wiley +1 more source