Results 61 to 70 of about 9,870 (205)

Effect of folic acid supplementation in pregnancy on preeclampsia: The folic acid clinical trial study [PDF]

open access: yes, 2013
Copyright © 2013 Shi Wu Wen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited ...
Champagne, J   +7 more
core   +4 more sources

Twenty Years of the Paediatric Radiation Oncology Society

open access: yesPediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT In 2005, the Paediatric Radiation Oncology Society (PROS), a multi‐professional association to promote radiotherapy for children and young people, was created. Its mission has been to educate those involved in this field, and to improve the standards of radiation oncology care for children, adolescents, and young adults across the globe, not ...
Mark N. Gaze   +18 more
wiley   +1 more source

Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings

open access: yesPediatric Discovery, Volume 3, Issue 2, June 2025.
Abstract Spina bifida is a birth defect resulting from abnormal embryonic development of the neural tube. Though spina bifida is divided into several subtypes, myelomeningocele—the most severe form of spina bifida often associated with a markedly diminished quality of life—accounts for a significant portion of cases.
Ethan S. Wong   +13 more
wiley   +1 more source

Identification of novel Mycobacterium tuberculosis dihydrofolate reductase inhibitors through rational drug design

open access: yesInternational Journal of Mycobacteriology, 2016
Objectives/Background: Dihydrofolate reductase (DHFR) is one of the validated drug targets in Mycobacterium tuberculosis (Mtb) infection. DHFR inhibitors have been used to treat various life-threatening diseases such as cancer, malaria, and several ...
Mymoona Akhter
doaj   +1 more source

Monoclonal Antibodies to Thyrotropin Receptor With Thyroid‐Stimulating Activity Activate the NF‐κB Pathway to Induce Chemokine Expression

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT The A subunit of thyrotropin receptor (TSHR) is thought to be the crucial gene mediating stimulatory autoantibodies in Graves' diease (GD), but it remains unclear what the molecular basis of this pathological antibody response is. Stimulatory TSHR autoantibodies may induce activation of multiple signalling pathways in GD, modulate chemokine ...
Yang Yang, Chen Hui
wiley   +1 more source

Dihydrofolate reductase of Streptococcus faecium II. Purification and some properties of two dihydrofolate reductases from the Amethopterin-resistant mutant, Streptococcus Faecium Var. Durans Strain A [PDF]

open access: yes, 1968
From a single amethopterin-resistant organism, Streptococcus faecium var. durans strain A, two different dihydrofolate reductases have been obtained as essentially homogeneous proteins in good yield.
Blakley, R. L., Nixon, P. F.
core  

Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. [PDF]

open access: yes, 1993
We have generated transgenic mice that express the immunoglobulin (Ig)M heavy chain and kappa light chain genes coding for a human IgM rheumatoid factor (RF), Les.
Carson, DA   +6 more
core   +2 more sources

A CLDN18.2‐Targeted Nanoplatform Manipulates Magnetic Hyperthermia Spatiotemporally for Synergistic Immunotherapy in Gastric Cancer

open access: yesAdvanced Science, Volume 12, Issue 16, April 24, 2025.
CLDN18.2 is a highly selective biomarker exposed in gastric cancer. A CLDN18.2‐specific antibody 1D5 conjugated fluorescence‐magnetic nanoparticle is developed for image‐guided precision theragnostics. Under the assistance of sensitive FMI and deep‐penetrating MPI for tracing and timing the optimal nanoparticle dosage, combining α‐PD1 therapy with ...
Xueying Wang   +14 more
wiley   +1 more source

Assignment of the Human and Mouse Prion Protein Genes to Homologous Chromosomes [PDF]

open access: yes, 1986
Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles.
Blatt, Cila   +13 more
core  

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