Results 51 to 60 of about 9,870 (205)
Avicenna Journal of Medical Biochemistry, 2015 Background Human Epidermal Growth factor Receptor 2 (HER2), also known as ErbB2 is a 185 kDa protein belonging to the Human Epidermal Receptor (HER) family of tyrosine kinase receptors overexpressed in 20% - 30% of patients with breast cancer ...
Nadri +6 more
doaj +1 more source
Advanced Science, Volume 12, Issue 44, November 27, 2025.This study developed mAb‐5F2, a monoclonal antibody targeting conserved GP4 residues (Q48/I50), which blocks the GP4‐CD163 interaction, resulting in a 78–85% reduction in viral entry. Porcineized 5F2‐pFc prevented mortality in infected piglets, reduced pulmonary viral loads, and minimized lesions. This broad‐spectrum antibody platform overcomes vaccine
Xu Chen +12 more
wiley +1 more source
Detailed analysis of X chromosome inactivation in a 49,XXXXX pentasomy
Molecular Cytogenetics, 2009 Background Pentasomy X (49,XXXXX) has been associated with a severe clinical condition, presumably resulting from failure or disruption of X chromosome inactivation. Here we report that some human X chromosomes from a patient with 49,XXXXX pentasomy were
Menezes Albert N +6 more
doaj +1 more source
Monoclonal antibodies reactive with swine lymphocytes [PDF]
, 1984 A panel of monoclonal antibodies (mAb) with specificity for swine leukocytes was prepared by somatic cell hybridization with the use of spleen cells from mice immunized with swine thymocytes.
Jonjic, Stipan, Koszinowski, Ulrich H.
core
DNA-Mediated Transfer of the Adenine Phosphoribosyltransferase Locus into Mammalian Cells [PDF]
, 1979 In this report, we demonstrate the feasibility of transforming mouse cells deficient in adenine phosphoribosyltransferase (aprt; AMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.7) to the aprt+ phenotype by means of DNA-mediated gene transfer ...
Wigler, M. H. +5 more
core +1 more source
Biotechnology and Bioengineering, Volume 122, Issue 11, Page 3192-3204, November 2025.ABSTRACT Despite evidence that they are not functional or infective, retrovirus‐like particles (RVLPs), originating from endogenous proviral sequences in Chinese hamster ovary (CHO) cells, present a safety risk for biotherapeutics manufactured using this cell line due to their resemblance to other mammalian leukemia viruses.
Matthew Stuible +8 more
wiley +1 more source
Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]
, 1989 Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Engler-Blum, G. +5 more
core +1 more source
Small, Volume 21, Issue 40, October 9, 2025.Immunogenicity evaluation in patients receiving mAb therapy is becoming the standard of care in healthcare systems worldwide. Nevertheless, current methods for anti‐drug antibody determination suffer from drug interference and/or inability to be performed at the point‐of‐care (POC).
Frans Kokojka +4 more
wiley +1 more source
Journal of Analytical Methods in Chemistry, 2019 Folic acid (FA) is an important vitamin for human growth, especially for pregnant women. FA deficiency is associated with megaloblastic anemia, neural tube defects, cardiovascular diseases, irritability, diarrhea, and psychiatric disorders.
Xiang Chen +7 more
doaj +1 more source
Birth Defects Research, Volume 117, Issue 9, September 2025.ABSTRACT Certain medications, when used during pregnancy, are known to impact human prenatal development. Historically, little attention has been given to the impact of in utero exposure on the developing brain, despite the significance of known teratogen‐induced neurodevelopmental difficulties.
M. Bluett‐Duncan +14 more
wiley +1 more source