Results 31 to 40 of about 9,870 (205)

Inhibitors of Human Dihydrofolate Reductase: A Computational Design and Docking Studies Using Glide

E-Journal of Chemistry, 2008
Dihydrofolate reductase (DHFR) plays a vital role in the DNA synthesis by reducing dihydrofolic acid to tetrahydrofolic acid which is an essential component.
Lingala Yamini, Manga Vijjulatha
doaj   +1 more source

Molecular Characteristics and Serodiagnostic Potential of Dihydrofolate Reductase from Echinococcus granulosus

Scientific Reports, 2017
The larval stage of Echinococcus granulosus causes cystic echinococcosis (CE), a neglected tropical disease that leads to morbidity and mortality in humans and livestock worldwide.
Xingju Song, Dandan Hu, Min Yan, Yu Wang, Ning Wang, Xiaobin Gu, Guangyou Yang   +6 more
doaj   +1 more source

Induction of the HSP70 gene promoter by various anticancer drugs [PDF]

, 1998
International audienceHeLa cells containing the chloramphenicol acetyl transferase (CAT) gene under the control of the hsp70 promoter have been exposed in vitro to various anticancer drugs. Cisplatin induced CAT production with a dose-effect relationship
Ait-Aissa, Selim, Arrigo, André-Patrick, Kretz-Remy, C., Lambre, Claude, Porcher, Jean-Marc, Velarde, G.   +5 more
core   +5 more sources

Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo [PDF]

, 2008
Murine L1210 leukaemia cells expressing either the reduced folate carrier (RFC) or the membrane folate receptor (MFR) were studied in vitro and in vivo to assess the dynamics of membrane transport of two categories antifolates; folate-based ...
Comijn, Elizabeth, Jansen, Gerrit, Kathmann, Ietje, Mauritz, Robert, Noordhuis, Paul, Peters, Godefridus, Pinedo, Herbert, Teshale, Habte   +7 more
core   +1 more source

Production and characterization of monoclonal antibodies to Brazilian isolates of bovine viral diarrhea virus

Brazilian Journal of Medical and Biological Research, 2000
Three Brazilian isolates of bovine viral diarrhea virus (BVDV), antigenically distinct from the standard North American isolates, were selected to immunize BALB/c mice in order to obtain hybridoma cells secreting anti-BVDV monoclonal antibodies (mAbs ...
L.C. Kreutz, R. Donis, L.H.V. Gil, M. Lima, A.N. Hoffman, D.C. Garcez, E.F. Flores, R. Weiblen   +7 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

Bvr-1, a Restriction Locus of a Type C RNA Virus in the Feline Cellular Genome: Pleiotropic Restriction of Endogenous BALB Virus in Cat x Mouse Somatic Cell Hybrids [PDF]

, 1978
Bvr-1 is a dominant X-linked feline gene which restricts the replication of B-tropic murineleukemia virus (B-MuLV) in somatic cell hybrids between murine BALB/c-RAG cells and FL-74 feline cells.
O\u27Brien, Stephen J., Simonson, Janice M.   +1 more
core   +2 more sources

Identification Epitope on VP4 Protein of Senecavirus A Recognized by a Monoclonal Antibody

Animal Research and One Health, EarlyView.
This study aims to identify conserved antigenic epitopes on the SVA VP4 protein using monoclonal antibodies, providing valuable tools for further exploring its functions and developing detection methods. SVA VP4 protein was expressed in Escherichia coli and purified with High‐Affinity Ni‐Charged Resin FF.
Liang Meng, Xuyan Xiang, Xinyu Qi, Hanrong Zhou, Peiyu Xiao, Fandan Meng, Tongqing An, Haiwei Wang   +7 more
wiley   +1 more source

Hybrid cell lines producing monoclonal antibodies directed against Treponema [PDF]

, 1985
Continuous hybrid cell lines for producing monoclonal antibodies directed against antigens of Treponema pallidum have been developed. The hybrid cell lines were established by fusing differentiated lymphoid cells primed with antigens of Treponema ...
Kettman, John R., Norgard, Michael V.
core   +1 more source

Computational and Spectroscopic Insights Into the Rice Bran Derived Glu‐Gln‐Arg‐Pro‐Arg Pentapeptide as an Anticancer Agent: A DFT, Molecular Docking, and Molecular Dynamics Study

International Journal of Quantum Chemistry, Volume 126, Issue 8, April 15, 2026.
Rice bran–derived neutral EQRPR (L‐Glu‐L‐Gln‐L‐Arg‐L‐Pro‐L‐Arg) pentapeptide was structurally and biologically characterized using DFT calculations, vibrational spectroscopy, molecular docking, and molecular dynamics simulations. The DFT/wb97xd/6–31++G(d,p) level of theory showed the best agreement with the experimental spectra.
Gozde Yilmaz, Sefa Celik, Aysen E. Ozel, Sevim Akyuz   +3 more
wiley   +1 more source