Results 21 to 30 of about 9,870 (205)

A Case of Severe Methotrexate Toxicity: Clinical Insights and Management [PDF]

Journal of Clinical and Diagnostic Research
Methotrexate (MTX), first synthesised in 1947, originated as a derivative of aminopterin, a medication initially used to treat acute leukaemia in children.
Pradnya Diggikar, Bhavya Sri Yammanaru, Tushar Pancholi, Manosri Mandadi, R Janani   +4 more
doaj   +1 more source

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. [PDF]

, 2014
BACKGROUND: The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent.
Arozarena, Imanol, Erice, O., Ferguson, J., Goicoechea, I., Margison, G.P., Wellbrock, C.   +5 more
core   +2 more sources

Induction of morphological aberrations by enzyme inhibition in Drosophila melanogaster [PDF]

, 1969
Zusatz zum Futter vonDrosophila melanogaster von 5-Fluoro-2-deoxyuridin oder Aminopterin induziert überzählige Skutellar- und Dorsozentralborsten sowie gekerbte Flügel.
Bijlsma, R., Boer, I.M. de, Bos, M., Hollander, J. den, Scharloo, W.   +4 more
core   +2 more sources

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. I. Effects of aminopterin and bromouracil on hemopoiesis and hemoglobin synthesis in anemic rat [PDF]

, 1968
For the purpose to see how the suppression of the nucleic acid synthesis disturbs the cell specialization process the author observed the erythroid cell specialization in anemic rats by treating them with aminopterin (AP) and 5-bromouracil (BU).
Shigehisa, Morio
core   +1 more source

A study on the magnitude of neural tube defects among newborns delivered at a tertiary care hospital

National Journal of Physiology, Pharmacy and Pharmacology, 2023
Background: In a developing fetus during the stages of embryogenesis, various congenital malformations tend to occur, among which neural tube defects (NTDs) are one of the more serious conditions.
Dravya Nilesh Mehta, Heetkumar Bharatkumar Patel, Pushti Vinodray Vachhani, Nishantkumar Ramniklal Bhimani   +3 more
doaj   +1 more source

Folate-based single cell screening using surface enhanced Raman microimaging [PDF]

, 2016
Recent progress in nanotechnology and its application to biomedical settings have generated great advantages in dealing with early cancer diagnosis.
Bordi, Federico, Costantini, Francesca, Domenici, F., Fasolato, Claudia, Giantulli, Sabrina, Luongo, F., Mazzarda, Flavia, Mura, Francesco, Postorino, Paolo, Ripanti, Francesca, Silvestri, Ida, Toumia, Y.   +11 more
core   +1 more source

Synthesis and In Vitro Biological Evaluation of β,γ-Methano Analogues of Methotrexate and Aminopterin

Pteridines, 1990
β,γ-Methano derivatives of methotrexate (MTX) and aminopterin (AMT) were synthesized with the aim of assessing the effect of this side-chain modification on dihydrofolate reductase (OHFR) inhibition, folylpolyglutamate synthetase (FPGS) inhibition, and ...
Rosowsky Andre, Forsch Ronald A., Moran Richard G., Freisheim James H.   +3 more
doaj   +1 more source

Avian retrovirus integrase-enhanced transgene integration into mammalian cell DNA in vivo

BioTechniques, 2003
Systems for introducing DNA genes-of-interest into mammalian cellular genomes have ranged from the use of different physical techniques to viruses including retroviruses.
Aqing Yao, Roger Chiu, Ajaykumar Vora, David B. Brown, Duane Grandgenett, Brian R. Davis   +5 more
doaj   +1 more source

Methotrexate Is a JAK/STAT Pathway Inhibitor. [PDF]

PLoS ONE, 2015
The JAK/STAT pathway transduces signals from multiple cytokines and controls haematopoiesis, immunity and inflammation. In addition, pathological activation is seen in multiple malignancies including the myeloproliferative neoplasms (MPNs).
Sally Thomas, Katherine H Fisher, John A Snowden, Sarah J Danson, Stephen Brown, Martin P Zeidler   +5 more
doaj   +1 more source

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells [PDF]

, 2017
The major-histocompatibility-complex-(MHC)-class-I-related molecule MR1 can present activating and non-activating vitamin-B-based ligands to mucosal-associated invariant T cells (MAIT cells). Whether MR1 binds other ligands is unknown. Here we identified
A Kurioka, AJ Corbett, AJ McCoy, AL Szymczak, Alexandra J Corbett, Andrew N Keller, Anthony W Purcell, Bronwyn S Meehan, BY Chua, Criselle D'Souza, Dale I Godfrey, David P Fairlie, DC Chatterji, DI Godfrey, E Treiner, EY Jones, F Koning, F Tilloy, HEG McWilliam, Huimeng Wang, I Kawachi, I Van Rhijn, IJ Skypala, James McCluskey, Jamie Rossjohn, JE Ussher, Jeffrey Y W Mak, L Kjer-Nielsen, L Le Bourhis, Lars Kjer-Nielsen, Ligong Liu, Lyudmila Kostenko, M Bharadwaj, M Dusseaux, M Lepore, M Salio, MC Gold, MD Winn, MHM Heemskerk, NA Gherardin, Nicholas A Gherardin, NM Davies, O Patel, P Emsley, PCD Hawkins, PD Adams, PF Fehlner, PJ Hashkes, PT Illing, R Reantragoon, R Reantragoon, Richard W Birkinshaw, S Gras, S Gras, S Huang, S Zelcer, SB Eckle, SB Eckle, Sidonia B G Eckle, SK Hoiseth, Troi Pediongco, V Krasniqi, VB Chen, VC Romão, Victoria A Hughes, Weijun Xu, WXDS Kabsch, Zhenjun Chen   +67 more
core   +2 more sources