Results 21 to 30 of about 6,112 (161)
Methotrexate Is a JAK/STAT Pathway Inhibitor. [PDF]
PLoS ONE, 2015 The JAK/STAT pathway transduces signals from multiple cytokines and controls haematopoiesis, immunity and inflammation. In addition, pathological activation is seen in multiple malignancies including the myeloproliferative neoplasms (MPNs).
Sally Thomas +5 more
doaj +1 more source
Inhibitors of Human Dihydrofolate Reductase: A Computational Design and Docking Studies Using Glide
E-Journal of Chemistry, 2008 Dihydrofolate reductase (DHFR) plays a vital role in the DNA synthesis by reducing dihydrofolic acid to tetrahydrofolic acid which is an essential component.
Lingala Yamini, Manga Vijjulatha
doaj +1 more source
On the Mechanism of Action of Aminopterin.
Experimental Biology and Medicine, 1950 SummaryRat liver slices form from synthetic folic acid (PGA) a factor (CF) utilized for growth by Leuconostoc citrovorum; this conversion is inhibited by aminopterin. In rats given PGA, a similar inhibition of the synthesis of CF is shown by a marked decrease in the urinary excretion of CF following the administration of aminopterin. The antagonist not
C A, NICHOL, A D, WELCH
openaire +2 more sources
Antifolate agent aminopterin demonstrates potent anti-monkeypox virus activity in vitro and in vivo
Microbiology SpectrumThe ongoing spread of the monkeypox outbreak underscores the urgent need for the development of effective therapeutics against the monkeypox virus (MPXV).
Jing Wu +3 more
doaj +1 more source
Scientific Reports, 2017 The larval stage of Echinococcus granulosus causes cystic echinococcosis (CE), a neglected tropical disease that leads to morbidity and mortality in humans and livestock worldwide.
Xingju Song +6 more
doaj +1 more source
Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Snake venoms show variability in composition at all taxonomic levels, both within and between species, and the selective pressures underlying this variation have long been debated.
Bálint Üveges +17 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2000 Three Brazilian isolates of bovine viral diarrhea virus (BVDV), antigenically distinct from the standard North American isolates, were selected to immunize BALB/c mice in order to obtain hybridoma cells secreting anti-BVDV monoclonal antibodies (mAbs ...
L.C. Kreutz +7 more
doaj +1 more source
Unexpected Acute Toxicity of Aminopterin [PDF]
Nature, 1964 THIS communication records the occurrence of a somewhat unusual form of acute toxicity which was observed in the course of an experiment designed to investigate the possible carcinogenicity of aminopterin. As part of this investigation aminopterin (C grade) (California Corporation for Biochemical Research, Los Angeles) was examined in new-born mice ...
B, TOTH, P, SHUBIK
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Abortion—A brief description of the evolution of methods
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.Termination of pregnancy is not a “modern” societal issue, but one that has been afforded to women, albeit with varying degrees of success, over many centuries. Methods have evolved which have increased the availability, effectiveness, and safety of abortion, while substantially reducing associated morbidity.
Laura Slade, Andrea Deussen, Jodie Dodd
wiley +1 more source