Results 11 to 20 of about 6,112 (161)

Syndecans in cancer: A review of function, expression, prognostic value, and therapeutic significance

Cancer Treatment and Research Communications, 2021
While our understanding of tumors and how to treat them has advanced significantly since the days of Aminopterin and the radical mastectomy, cancer remains among the leading causes of death worldwide.
Daniel Czarnowski
doaj   +1 more source

Preparation of human monoclonal anti-C cell line from peripheral blood B lymphocytes of D--donor

Zhongguo shuxue zazhi, 2022
Objective To establish human hybridoma cell lines, secreting monoclonal antibody against antigens of Rh blood system, from a donor with rare D--phenotype.
Zhonghui GUO, Fengyong ZHAO, Demei ZHANG, Dong XIANG, Jiamin ZHANG, Ying YANG, Qin LI, Qixiu YANG, Chen WANG, Ziyan ZHU   +9 more
doaj   +1 more source

Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis

Journal of Neuroinflammation, 2021
Background Activated macrophages in the experimental model of multiple sclerosis (MS) express folate receptor-β (FR-β), representing a promising target for the treatment of MS. Here, we both evaluated the efficacy of a novel folate-aminopterin construct (
Petri Elo, Xiang-Guo Li, Heidi Liljenbäck, Maria Gardberg, Olli Moisio, Maxwell Miner, Jenni Virta, Antti Saraste, Madduri Srinivasarao, Michael Pugh, Philip S. Low, Juhani Knuuti, Sirpa Jalkanen, Laura Airas, Yingjuan June Lu, Anne Roivainen   +15 more
doaj   +1 more source

Identification of Unique and Conserved Neutralizing Epitopes of Vestigial Esterase Domain in HA Protein of the H9N2 Subtype of Avian Influenza Virus

Viruses, 2022
The H9N2 subtype of avian influenza virus (AIV) has been reported to infect not only birds, but also humans. The hemagglutinin (HA) protein is the main surface antigen of AIV and plays an important role in the viral infection.
Xiangyu Huang, Guihu Yin, Yiqin Cai, Jianing Hu, Jingwen Huang, Qingtao Liu, Xiuli Feng   +6 more
doaj   +1 more source

LD-aminopterin in the canine homologue of human atopic dermatitis: a randomized, controlled trial reveals dosing factors affecting optimal therapy.

PLoS ONE, 2014
BackgroundOptions are limited for patients with atopic dermatitis (AD) who do not respond to topical treatments. Antifolate therapy with systemic methotrexate improves the disease, but is associated with adverse effects. The investigational antifolate LD-
John A Zebala, Alan Mundell, Linda Messinger, Craig E Griffin, Aaron D Schuler, Stuart J Kahn   +5 more
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An ultra-sensitive monoclonal antibody-based competitive enzyme immunoassay for sterigmatocystin in cereal and oil products. [PDF]

PLoS ONE, 2014
Sterigmatocystin (STG), a biosynthesis precursor of aflatoxin B1, is well known for its toxic and carcinogenic effects in humans and animals. STG derivatives and protein conjugates are needed for generation of monoclonal antibodies (mAbs).
Min Li, Peiwu Li, Hui Wu, Qi Zhang, Fei Ma, Zhaowei Zhang, Xiaoxia Ding, Hengling Wang   +7 more
doaj   +1 more source

A Case of Severe Methotrexate Toxicity: Clinical Insights and Management [PDF]

Journal of Clinical and Diagnostic Research
Methotrexate (MTX), first synthesised in 1947, originated as a derivative of aminopterin, a medication initially used to treat acute leukaemia in children.
Pradnya Diggikar, Bhavya Sri Yammanaru, Tushar Pancholi, Manosri Mandadi, R Janani   +4 more
doaj   +1 more source

A study on the magnitude of neural tube defects among newborns delivered at a tertiary care hospital

National Journal of Physiology, Pharmacy and Pharmacology, 2023
Background: In a developing fetus during the stages of embryogenesis, various congenital malformations tend to occur, among which neural tube defects (NTDs) are one of the more serious conditions.
Dravya Nilesh Mehta, Heetkumar Bharatkumar Patel, Pushti Vinodray Vachhani, Nishantkumar Ramniklal Bhimani   +3 more
doaj   +1 more source

Synthesis and In Vitro Biological Evaluation of β,γ-Methano Analogues of Methotrexate and Aminopterin

Pteridines, 1990
β,γ-Methano derivatives of methotrexate (MTX) and aminopterin (AMT) were synthesized with the aim of assessing the effect of this side-chain modification on dihydrofolate reductase (OHFR) inhibition, folylpolyglutamate synthetase (FPGS) inhibition, and ...
Rosowsky Andre, Forsch Ronald A., Moran Richard G., Freisheim James H.   +3 more
doaj   +1 more source

Avian retrovirus integrase-enhanced transgene integration into mammalian cell DNA in vivo

BioTechniques, 2003
Systems for introducing DNA genes-of-interest into mammalian cellular genomes have ranged from the use of different physical techniques to viruses including retroviruses.
Aqing Yao, Roger Chiu, Ajaykumar Vora, David B. Brown, Duane Grandgenett, Brian R. Davis   +5 more
doaj   +1 more source