Artificial metabzyme-driven metabolic reprogramming and precision oncology. [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 15, Issue 2, February 2025.
Hu X, Ling D.
europepmc +2 more sources
Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti. [PDF]
PLoS ONE, 2018 Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR ...
Andrew M Tobias +8 more
doaj +1 more source
Cancer Treatment and Research Communications, 2021 While our understanding of tumors and how to treat them has advanced significantly since the days of Aminopterin and the radical mastectomy, cancer remains among the leading causes of death worldwide.
Daniel Czarnowski
doaj +1 more source
Preparation of human monoclonal anti-C cell line from peripheral blood B lymphocytes of D--donor
Zhongguo shuxue zazhi, 2022 Objective To establish human hybridoma cell lines, secreting monoclonal antibody against antigens of Rh blood system, from a donor with rare D--phenotype.
Zhonghui GUO +9 more
doaj +1 more source
Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis
Journal of Neuroinflammation, 2021 Background Activated macrophages in the experimental model of multiple sclerosis (MS) express folate receptor-β (FR-β), representing a promising target for the treatment of MS. Here, we both evaluated the efficacy of a novel folate-aminopterin construct (
Petri Elo +15 more
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Viruses, 2022 The H9N2 subtype of avian influenza virus (AIV) has been reported to infect not only birds, but also humans. The hemagglutinin (HA) protein is the main surface antigen of AIV and plays an important role in the viral infection.
Xiangyu Huang +6 more
doaj +1 more source
Studies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil [PDF]
, 1968 With the bone marrow of anemic rats, which had received the repeated injections of phenylhydrazine once a day for three to four days, the effects of aminopterin and bromouracil on the nucleic acid metabolism of erythroblasts were observed in vivo ...
Shigehisa, Morio
core +1 more source
An ultra-sensitive monoclonal antibody-based competitive enzyme immunoassay for sterigmatocystin in cereal and oil products. [PDF]
PLoS ONE, 2014 Sterigmatocystin (STG), a biosynthesis precursor of aflatoxin B1, is well known for its toxic and carcinogenic effects in humans and animals. STG derivatives and protein conjugates are needed for generation of monoclonal antibodies (mAbs).
Min Li +7 more
doaj +1 more source
PLoS ONE, 2014 BackgroundOptions are limited for patients with atopic dermatitis (AD) who do not respond to topical treatments. Antifolate therapy with systemic methotrexate improves the disease, but is associated with adverse effects. The investigational antifolate LD-
John A Zebala +5 more
doaj +1 more source
Studies on the relation between heme and nucleic acid syntheses in erythroid cell. 3. Nucleolus of erythroblast, changes in relation with cell specialization [PDF]
, 1969 The disappearance of nucleolus has been traced in the rat erythroid cells in relation with the cell specialization under varying conditions, i. e. in anemia with or without treatment by bromouracil and aminopterin.
Shigehisa, Morio
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