Results 1 to 10 of about 6,093 (142)

The first achievement of complete remission in childhood leukemia by treatment with the folic acid antagonist aminopterin. [PDF]

Haematologica, 2022
TITLE Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin). AUTHORS Farber S, Diamond LK. Mercer RD, Slyvester RF Jr, Wolff JA.
Izraeli S.
europepmc   +2 more sources

Quantifying Epigenetic Changes Induced by Chemical Exposure Using the epi-TK Assay. [PDF]

Bio Protoc
Epigenetic modifications play essential roles in regulating gene expression and maintaining cellular identity. Accumulating evidence suggests that chemical agents can contribute to carcinogenesis through epigenetic alterations, such as changes in DNA ...
Kuroki S, Yamada H, Odagiri M, Sugiyama KI, Yasui M, Sassa A.   +5 more
europepmc   +2 more sources

Generation of monoclonal antibody against 6-Keto PGF_1α and development of ELISA for its quantification in culture medium. [PDF]

Biochem Biophys Rep
Prostacyclin or prostaglandin I2 (PGI2), a metabolite of arachidonic cyclooxygenase pathway, has been demonstrated as an effector of adipocyte differentiation.
Chowdhury MMI, Kabir N, Ahmed R, Yokota K, Mullins R, Reza HM.   +5 more
europepmc   +2 more sources

STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis. [PDF]

Mol Cancer
Background Serine/threonine kinase 3 (STK3) is recognized as a key regulator in Hippo pathway and a tumor-suppressing gene in various cancer types. However, its non-canonical role has been gradually revealed in cancer development.
Xie F, Lyu Y, Chen B, Leung HW, Yu P, Feng T, Fang C, Cheung AHK, Zhou B, Jiang J, Zhang G, Xu D, Li L, Jiang C, Chen J, Zhou Z, An L, Huang B, Zhuang K, Luo X, Leung KT, To CH, Ma BB, Wong CC, Wu WK, Yu J, To KF, Kang W.   +27 more
europepmc   +2 more sources

Investigating monoclonal antibody against cytokeratin 19 tumor marker. [PDF]

BMC Immunol
Cytokeratin 19 (CK 19) is a member of the intermediate filaments that are widely expressed in thyroid, breast, colon, small and non-small cell lung, and prostate cancer cells. This paper aims to produce the monoclonal antibody against CK 19.
Momeni-Moghaddam MA, Mohammadnejad J, Ghahremani H, Khaghani S, Moradi N, Daemi A, Özbolat G, Döğüş Y, Hosseini ST.   +8 more
europepmc   +2 more sources

Innovative approaches in QSPR modelling using topological indices for the development of cancer treatments. [PDF]

PLoS One
This paper provides a comprehensive review of quantitative structure-property relationships (QSPR) about to cancer drugs, with a focus on the application of topological indices (TI) and data analysis techniques.
Shi X, Kosari S, Ghods M, Kheirkhahan N.
europepmc   +2 more sources

Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes

Cell Reports Medicine, 2021
Summary: Provoked by sterile/nonsterile insults, prolonged monocyte mobilization and uncontrolled monocyte/macrophage activation can pose imminent or impending harm to the affected organs. Curiously, folate receptor beta (FRβ), with subnanomolar affinity
Yingjuan J. Lu, Leroy W. Wheeler, II, Haiyan Chu, Paul J. Kleindl, Michael Pugh, Fei You, Satish Rao, Gabriela Garcia, Henry Y. Wu, Andre P. da Cunha, Richard Johnson, Elaine Westrick, Vicky Cross, Alex Lloyd, Christina Dircksen, Patrick J. Klein, Iontcho R. Vlahov, Philip S. Low, Christopher P. Leamon   +18 more
doaj   +1 more source

A Novel Treatment for Glomerular Disease: Targeting the Activated Macrophage Folate Receptor with a Trojan Horse Therapy in Rats

Cells, 2021
Since activated macrophages express a functional folate receptor β (FRβ), targeting this macrophage population with folate-linked drugs could increase selectivity to treat inflammatory diseases.
Gabriela E. Garcia, Yingjuan J. Lu, Luan D. Truong, Carlos A. Roncal-Jiménez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Gabriel Cara-Fuentes, Ana Andres-Hernando, Miguel Lanaspa, Richard J. Johnson, Christopher P. Leamon   +10 more
doaj   +1 more source

Facile engineering of chitosan-coated aminopterin loaded zeolitic imidazolate framework: promising drug delivery system for breast cancer

Journal of Experimental Nanoscience, 2023
In this study, we have designed an anticancer drug delivery framework by a one-pot technique using a zeolitic imidazolate framework (ZIF) as the carrier. The chitosan-coated Aminopterin (AMT) loaded with zeolitic imidazolate framework (ZIF-90) CS@AMT@ZIF-
Limin Zhu, Shuangyan Wang
doaj   +1 more source

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti. [PDF]

PLoS ONE, 2018
Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR ...
Andrew M Tobias, Dea Toska, Keith Lange, Tyler Eck, Rohit Bhat, Cheryl A Janson, David P Rotella, Ueli Gubler, Nina M Goodey   +8 more
doaj   +1 more source