Results 11 to 20 of about 28,342 (216)

Neuroprotective Properties of 4-Aminopyridine [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2021
As an antagonist of voltage-gated potassium (Kv) channels, 4-aminopyridine (4-AP) is used as symptomatic therapy in several neurologic disorders. The improvement of visual function and motor skills and relieve of fatigue in patients with MS have been attributed to 4-AP.
Dietrich, Michael, Hartung, Hans-Peter, Albrecht, Philipp   +2 more
openaire   +2 more sources

Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]

, 1982
The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Baranyi, Ben-Ari, Brismar, Brown, Buckle, Collins, Constanti, DiFrancesco, Dingemanse, Galvan, Galvan, Galvan, Gerrit Ten Bruggencate, Gilbey, Golenhofen, Halliwell, Heinemann, Jankowska, Jefferys, Kocsis, Lemeignan, Lipicky, Llinaś, Lundh, Martin Galvan, Matthews, McAfee, Mori, Neuman, Nicholson, Nicoll, Pelhate, Peter Grafe, Pichon, Scholfield, Scholfield, Schwartzkroin, Schwartzkroin, Sherratt, Shimahara, Spyker, Szente, Thesleff, Thompson, Ulbricht, von Haxthausen, Yanagisawa, Yeh   +47 more
core   +1 more source

4-aminopyridine – the new old drug for the treatment of neurodegenerative diseases [PDF]

Pharmacia, 2019
In this review are described the preclinical and clinical pharmacological data as well as new therapeutic indications for the use of 4-aminopyridine.
Ivanka Kostadinova, Nikolai Danchev
doaj   +3 more sources

Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro [PDF]

, 1980
Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion.
A Nistri, A Tokunaga, B Hue, B Katz, C Nicholson, CL Schauf, DA Brown, DA Brown, DA Brown, DA Brown, DA McAfee, DI Wallis, E Jankowska, E Kato, E Kato, G. ten Bruggencate, H Lundh, H Lundh, H Meves, IG Marshall, JE Heuser, JZ Yeh, JZ Yeh, K Golenhofen, M Lemeignan, M Lemeignan, M. Galvan, NG Bowery, P. Grafe, PR Adams, R Llinás, SY Chiu, T Brismar, T Yanagisawa, W Ulbricht, WC Bowman, WW Douglas   +36 more
core   +1 more source

Synthesis of 2-aminopyridine Lactones and Studies of Their Antioxidant, Antibacterial and Antifungal Properties

Chemistry Proceedings, 2021
In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, followed by ...
Fadila Salhi, Nawel Cheikh, Didier Villemin, Nathalie Bar   +3 more
doaj   +1 more source

Crystal structures of N ′-Aminopyridine-2-carboximidamide and N ′-{[1-(pyridin-2-yl)ethylidene]amino}pyridine-2-carboximidamide [PDF]

, 2017
© Eya'ane Meva et al. 2017. The crystal structures of N,-Aminopyridine-2-carboximidamide (C 6 H 8 N 4 ), 1, and N,-{[1-(pyridin-2-yl)ethylidene]amino}pyridine-2-carboximidamide (C 13 H 13 N 5 ), 2, are described.
Evans, David John, Mang, Emmanuel Roland, Meva, Francois Eya'ane, Prior, Timothy John   +3 more
core   +2 more sources

4-Aminopyridine Decreases MPTP-Induced Behavioral Disturbances in Animal Model of Parkinson’s Disease

International Clinical Neuroscience Journal, 2015
Background and purpose: Progressive degeneration of dopaminergic neurons in the midbrain is the main mechanism of Parkinson’s disease (PD). Although potassium channels affect neural activity and death in this area, little research has investigated the ...
Reza Taherian, Mehran Arab Ahmadi
doaj   +1 more source

Redetermination of para-aminopyridine (fampridine, EL-970) at 150 K [PDF]

, 2005
The structure of fampridine (EL-970) or 4-aminopyridine, C₅H₆N₂, has been redetermined at 150 K. The room-temperature structure has been reported previously [Chao & Schempp (1977). Acta Cryst. B33, 1557-1564]. Pyramidalization at the amine N atom occurs
Anderson, Frankie P., Gallagher, John F., Kenny, Peter T.M., Lough, Alan J.   +3 more
core   +1 more source

2-Deoxystreptamine Conjugates by Truncation–Derivatization of Neomycin

Pharmaceuticals, 2010
A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose, oxidation-conjugation of aminopyridine/aminoquinoline and finally dimerization.
Floris L. van Delft, Floris P.J.T. Rutjes, Gerard W. Canters, Alessio Andreoni, Leandro C. Tabares, M. Waqar Aslam   +5 more
doaj   +1 more source

Dynamic walking features and improved walking performance in multiple sclerosis patients treated with fampridine (4-aminopyridine) [PDF]

, 2015
Background: Impaired walking capacity is a frequent confinement in Multiple Sclerosis (MS). Patients are affected by limitations in coordination, walking speed and the distance they may cover.
A Chetta, A Compston, AD Goodman, AD Goodman, AD Goodman, AD Goodman, Adam J. Cocks, AR Blight, AV Krishnan, BC Kieseier, CT Bever, HB Jensen, Jana Muenssinger, Janina M. Burschka, JM Burschka, JM Burschka, JS Fischer, MD Goldman, Patrick Oschmann, Philipp M. Keune, PM Rossini, RW Motl, RW Motl, RW Motl, S Savci, Sascha Hansen, SR Schwid, Ulrich Hofstadt-van Oy, WI McDonald, William R. Young   +29 more
core   +2 more sources