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4-Aminopyridine kinetics

Clinical Pharmacology and Therapeutics, 1982
Nine healthy subjects (7 men; 2 women) received single 20-mg IV injections of 4-aminopyridine (4-AP). Six of the subjects received the same dose in the form of enteric-coated tablets and four the same dose in uncoated tablets; treatments were at least 2 wk apart.
UGES, DRA   +4 more
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Aminopyridine-induced seizure activity

Electroencephalography and Clinical Neurophysiology, 1979
Typical seizure activity can be induced by applying 3-aminopyridine to the surface of the cat cortex. The well known characteristics of epileptiform discharges were readily observed by simultaneous recording from both the surface and deeper layers.
M, Szente, F, Pongrácz
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6-Aminopyridine-3-thiol

Acta Crystallographica Section C Crystal Structure Communications, 2002
The title compound, C(5)H(6)N(2)S, is a simple but novel pyridinethiol of pharmacological interest. The molecule is planar. The crystal packing is dominated by hydrophobic contacts and a pair of hydrogen-bond interactions between the amino group of one pyridine molecule and the ring N atom of a neighbouring base, stabilizing the structure.
J R, Sabino   +2 more
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Positron annihilation studies in solid 2-aminopyridine, 3-aminopyridine, 4-aminopyridine and 2-aminopyrimidine

Chemical Physics Letters, 1985
Abstract Positron annihilation lifetimes and Doppler-broadened annihilation lines have been measured in solid 2-aminopyridine (2-APY), 3-aminopyridine (3-APY), 4-aminopyridine (4-APY) and 2-aminopyrimidine (2-APYM). The results point to the formation of positronium in the solid pyridines and the yields are discussed in terms of the structures and the
A. Marques Netto   +3 more
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ChemInform Abstract: AMINOPYRIDINES

Chemischer Informationsdienst, 1980
AbstractDurch Umsetzung des Propiolesters (I) mit den Acetamiden (II) werden die Pyridindiole (III) dargestellt.
W. + JUENEMANN   +2 more
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INDO theoretical studies of 4-aminopyridine and protonated 4-aminopyridine

Journal of the Chemical Society, Perkin Transactions 2, 1975
Geometry optimized INDO calculations have been performed on 4-aminopyridine (2) and protonated 4-aminopyridine (1) in order to compare their optimized geometries, π-bond orders, C(4)–NH2 rotational barriers, charge densities, and π-electron distributions. It had previously been shown that 4-aminopyridine falls far off a linear correlation of ΔG° and ΔS°
Charles U. Pittman   +2 more
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Facile synthesis of functionalized 4-aminopyridines

Chemical Communications, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Nagatoshi, Nishiwaki   +5 more
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Alkylation of 4-aminopyridine

Chemistry of Heterocyclic Compounds, 1971
4-Alkylaminopyridines are formed by the alkylation of 4-aminopyridine with cyclohexanol, cyclopentanol, and 2-propanol in sulfuric acid.
S. I. Burmistrov, A. V. Krasovskii
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Homolytic ethoxycarbonylation of aminopyridines

Chemistry of Heterocyclic Compounds, 1988
Pyridinecarboxylic acid ethyl esters are formed in the reaction of ethoxycarbonyl radicals with aminopyridines.
R. S. Min, V. S. Aksenov
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